Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling
The PI3K/AKT signaling pathway is carefully regulated in specific cellular compartments. Lee and colleagues show that the housekeeping gene glutamyl-prolyl-tRNA synthetase 1 coordinates early endosome-specific AKT signaling necessary for inflammation resolution.
Main Authors: | Eun-Young Lee, Su-Man Kim, Jung Hwan Hwang, Song Yee Jang, Shinhye Park, Sanghyeon Choi, Ga Seul Lee, Jungwon Hwang, Jeong Hee Moon, Paul L. Fox, Sunghoon Kim, Chul-Ho Lee, Myung Hee Kim |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-34226-4 |
Similar Items
-
Phosphocode-dependent glutamyl-prolyl-tRNA synthetase 1 signaling in immunity, metabolism, and disease
by: Eun-Young Lee, et al.
Published: (2023-10-01) -
Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis
by: Dae-Geun Song, et al.
Published: (2018-11-01) -
Origin and evolution of glutamyl-prolyl tRNA synthetase WHEP domains reveal evolutionary relationships within Holozoa.
by: Partho Sarothi Ray, et al.
Published: (2014-01-01) -
Cardiomyocyte-Specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy
by: Jiangbin Wu, et al.
Published: (2023-12-01) -
Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1
by: Ina Yoon, et al.
Published: (2023-07-01)