A Comparative Biochemical Study of Proteins Profile in Iraqi Children and Adolescent with ?-Thalassemia
The aim of the present research is to study different protein fractions in sera of children and adolescent with β –thalassemia major and minor and to compare the results with that of healthy control.One hundred fifty children and adolescents were enrolled in this study,including 50 patients wit...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of Pharmacy University of Baghdad
2017-03-01
|
| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/501 |
| _version_ | 1828170609367973888 |
|---|---|
| author | Ali M. Malik Emad M. Malik Nawal MJ Al-Shammaa Zeinab M. Al-Rubaei |
| author_facet | Ali M. Malik Emad M. Malik Nawal MJ Al-Shammaa Zeinab M. Al-Rubaei |
| author_sort | Ali M. Malik |
| collection | DOAJ |
| description |
The aim of the present research is to study different protein fractions in sera of children and adolescent with β –thalassemia major and minor and to compare the results with that of healthy control.One hundred fifty children and adolescents were enrolled in this study,including 50 patients with β- thalassemia major , 50 patients with β- thalassemia minor as pathological control group and another apparently 50 healthy individuals as a control group. The age of all studied groups ranged from (4-18)years.Total protein, albumin and immunoglobulins were estimated in sera of all subjects. A Significant decrease was found in the total protein and albumin levels in sera of both major and minor thalassemic patients compared to normal groups. A Significant increase in immunoglobulin levels (IgG, IgM and IgA) was found in the sera of major and minor β-thalassemia patients compared to control.Different protein parts in sera of all subjects were detected using cellulose acetate electrophoresis.The results revealed significant reduction in β- globulin fractions in β- thalassemia major patients compared to the normal and pathological control groups. Significant elevations in γ- globulins fractions were observed in both major β- thalassemia and minor β- thalassemia as compared to normal control group. As a Conclusion the alteration in some protein parts occurred which is more obvious in major thalassemia patients compared to the normal and pathological control groups.
Key words: Protein Parts , Elecrtrophoresis , β-Thalassemia
|
| first_indexed | 2024-04-12T03:14:16Z |
| format | Article |
| id | doaj.art-5e323a6127ff4e6e89e070a93979ee5b |
| institution | Directory Open Access Journal |
| issn | 2521-3512 1683-3597 |
| language | English |
| last_indexed | 2024-04-12T03:14:16Z |
| publishDate | 2017-03-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-5e323a6127ff4e6e89e070a93979ee5b2022-12-22T03:50:15ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972017-03-0119210.31351/vol19iss2pp19-23A Comparative Biochemical Study of Proteins Profile in Iraqi Children and Adolescent with ?-ThalassemiaAli M. MalikEmad M. MalikNawal MJ Al-ShammaaZeinab M. Al-Rubaei The aim of the present research is to study different protein fractions in sera of children and adolescent with β –thalassemia major and minor and to compare the results with that of healthy control.One hundred fifty children and adolescents were enrolled in this study,including 50 patients with β- thalassemia major , 50 patients with β- thalassemia minor as pathological control group and another apparently 50 healthy individuals as a control group. The age of all studied groups ranged from (4-18)years.Total protein, albumin and immunoglobulins were estimated in sera of all subjects. A Significant decrease was found in the total protein and albumin levels in sera of both major and minor thalassemic patients compared to normal groups. A Significant increase in immunoglobulin levels (IgG, IgM and IgA) was found in the sera of major and minor β-thalassemia patients compared to control.Different protein parts in sera of all subjects were detected using cellulose acetate electrophoresis.The results revealed significant reduction in β- globulin fractions in β- thalassemia major patients compared to the normal and pathological control groups. Significant elevations in γ- globulins fractions were observed in both major β- thalassemia and minor β- thalassemia as compared to normal control group. As a Conclusion the alteration in some protein parts occurred which is more obvious in major thalassemia patients compared to the normal and pathological control groups. Key words: Protein Parts , Elecrtrophoresis , β-Thalassemia https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/501 |
| spellingShingle | Ali M. Malik Emad M. Malik Nawal MJ Al-Shammaa Zeinab M. Al-Rubaei A Comparative Biochemical Study of Proteins Profile in Iraqi Children and Adolescent with ?-Thalassemia Iraqi Journal of Pharmaceutical Sciences |
| title | A Comparative Biochemical Study of Proteins Profile in Iraqi Children and Adolescent with ?-Thalassemia |
| title_full | A Comparative Biochemical Study of Proteins Profile in Iraqi Children and Adolescent with ?-Thalassemia |
| title_fullStr | A Comparative Biochemical Study of Proteins Profile in Iraqi Children and Adolescent with ?-Thalassemia |
| title_full_unstemmed | A Comparative Biochemical Study of Proteins Profile in Iraqi Children and Adolescent with ?-Thalassemia |
| title_short | A Comparative Biochemical Study of Proteins Profile in Iraqi Children and Adolescent with ?-Thalassemia |
| title_sort | comparative biochemical study of proteins profile in iraqi children and adolescent with thalassemia |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/501 |
| work_keys_str_mv | AT alimmalik acomparativebiochemicalstudyofproteinsprofileiniraqichildrenandadolescentwiththalassemia AT emadmmalik acomparativebiochemicalstudyofproteinsprofileiniraqichildrenandadolescentwiththalassemia AT nawalmjalshammaa acomparativebiochemicalstudyofproteinsprofileiniraqichildrenandadolescentwiththalassemia AT zeinabmalrubaei acomparativebiochemicalstudyofproteinsprofileiniraqichildrenandadolescentwiththalassemia AT alimmalik comparativebiochemicalstudyofproteinsprofileiniraqichildrenandadolescentwiththalassemia AT emadmmalik comparativebiochemicalstudyofproteinsprofileiniraqichildrenandadolescentwiththalassemia AT nawalmjalshammaa comparativebiochemicalstudyofproteinsprofileiniraqichildrenandadolescentwiththalassemia AT zeinabmalrubaei comparativebiochemicalstudyofproteinsprofileiniraqichildrenandadolescentwiththalassemia |