The Skin Microbiome: Current Landscape and Future Opportunities
Our skin is the largest organ of the body, serving as an important barrier against the harsh extrinsic environment. Alongside preventing desiccation, chemical damage and hypothermia, this barrier protects the body from invading pathogens through a sophisticated innate immune response and co-adapted...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/4/3950 |
| _version_ | 1797620402097225728 |
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| author | Paisleigh Smythe Holly N. Wilkinson |
| author_facet | Paisleigh Smythe Holly N. Wilkinson |
| author_sort | Paisleigh Smythe |
| collection | DOAJ |
| description | Our skin is the largest organ of the body, serving as an important barrier against the harsh extrinsic environment. Alongside preventing desiccation, chemical damage and hypothermia, this barrier protects the body from invading pathogens through a sophisticated innate immune response and co-adapted consortium of commensal microorganisms, collectively termed the microbiota. These microorganisms inhabit distinct biogeographical regions dictated by skin physiology. Thus, it follows that perturbations to normal skin homeostasis, as occurs with ageing, diabetes and skin disease, can cause microbial dysbiosis and increase infection risk. In this review, we discuss emerging concepts in skin microbiome research, highlighting pertinent links between skin ageing, the microbiome and cutaneous repair. Moreover, we address gaps in current knowledge and highlight key areas requiring further exploration. Future advances in this field could revolutionise the way we treat microbial dysbiosis associated with skin ageing and other pathologies. |
| first_indexed | 2024-03-11T08:41:51Z |
| format | Article |
| id | doaj.art-5e355ba422074a898b91e1d3fdef755c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:41:51Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5e355ba422074a898b91e1d3fdef755c2023-11-16T21:07:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244395010.3390/ijms24043950The Skin Microbiome: Current Landscape and Future OpportunitiesPaisleigh Smythe0Holly N. Wilkinson1Centre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UKCentre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UKOur skin is the largest organ of the body, serving as an important barrier against the harsh extrinsic environment. Alongside preventing desiccation, chemical damage and hypothermia, this barrier protects the body from invading pathogens through a sophisticated innate immune response and co-adapted consortium of commensal microorganisms, collectively termed the microbiota. These microorganisms inhabit distinct biogeographical regions dictated by skin physiology. Thus, it follows that perturbations to normal skin homeostasis, as occurs with ageing, diabetes and skin disease, can cause microbial dysbiosis and increase infection risk. In this review, we discuss emerging concepts in skin microbiome research, highlighting pertinent links between skin ageing, the microbiome and cutaneous repair. Moreover, we address gaps in current knowledge and highlight key areas requiring further exploration. Future advances in this field could revolutionise the way we treat microbial dysbiosis associated with skin ageing and other pathologies.https://www.mdpi.com/1422-0067/24/4/3950microbiomeskinageingsenescencewound healinginfection |
| spellingShingle | Paisleigh Smythe Holly N. Wilkinson The Skin Microbiome: Current Landscape and Future Opportunities International Journal of Molecular Sciences microbiome skin ageing senescence wound healing infection |
| title | The Skin Microbiome: Current Landscape and Future Opportunities |
| title_full | The Skin Microbiome: Current Landscape and Future Opportunities |
| title_fullStr | The Skin Microbiome: Current Landscape and Future Opportunities |
| title_full_unstemmed | The Skin Microbiome: Current Landscape and Future Opportunities |
| title_short | The Skin Microbiome: Current Landscape and Future Opportunities |
| title_sort | skin microbiome current landscape and future opportunities |
| topic | microbiome skin ageing senescence wound healing infection |
| url | https://www.mdpi.com/1422-0067/24/4/3950 |
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