Circulating Levels of IL-8 and MCP-1 in Healthy Adults: Changes after an Acute Aerobic Exercise and Association with Body Composition and Energy Metabolism
The most recent WHO recommendations about physical activity emphasise the importance of total exercise volume above the significance of the duration of each bout. This study examined whether acute aerobic exercise changes circulating levels of IL-8 and MCP-1 and if these changes are associated with...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14725 |
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| author | Rudite Lagzdina Maija Rumaka Gita Gersone Peteris Tretjakovs |
| author_facet | Rudite Lagzdina Maija Rumaka Gita Gersone Peteris Tretjakovs |
| author_sort | Rudite Lagzdina |
| collection | DOAJ |
| description | The most recent WHO recommendations about physical activity emphasise the importance of total exercise volume above the significance of the duration of each bout. This study examined whether acute aerobic exercise changes circulating levels of IL-8 and MCP-1 and if these changes are associated with body composition and energy metabolism. Healthy adult volunteers completed a 10 min walking–running exercise on a treadmill. Indirect calorimetry was used to determine their resting metabolic rate (RMR) and energy expenditure (EE) during the exercise. Pre-exercise levels of IL-8 and MCP-1 were similar in both sexes. There were positive correlations of pre-exercise IL-8 with body mass, waist circumference, and lean body mass in men and pre-exercise MCP-1 with RMR in women. The exercise led to an increase in IL-8 of 68% and a decrease in MCP-1 of 74% of participants. An increase in post-exercise IL-8 in men was associated with greater walking EE and a greater increase in walking EE. The increase in post-exercise MCP-1 was associated with a lower RMR and running EE in women. There are both sex and individual variations in changes in chemokine secretion in response to the same exercise situation and their associations with values of metabolic parameters. |
| first_indexed | 2024-03-10T21:42:42Z |
| format | Article |
| id | doaj.art-5e37262c4c714abba22fde0de500a297 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:42:42Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5e37262c4c714abba22fde0de500a2972023-11-19T14:30:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124191472510.3390/ijms241914725Circulating Levels of IL-8 and MCP-1 in Healthy Adults: Changes after an Acute Aerobic Exercise and Association with Body Composition and Energy MetabolismRudite Lagzdina0Maija Rumaka1Gita Gersone2Peteris Tretjakovs3Department of Human Physiology and Biochemistry, Faculty of Medicine, Riga Stradiņš University, LV-1007 Riga, LatviaDepartment of Human Physiology and Biochemistry, Faculty of Medicine, Riga Stradiņš University, LV-1007 Riga, LatviaDepartment of Human Physiology and Biochemistry, Faculty of Medicine, Riga Stradiņš University, LV-1007 Riga, LatviaDepartment of Human Physiology and Biochemistry, Faculty of Medicine, Riga Stradiņš University, LV-1007 Riga, LatviaThe most recent WHO recommendations about physical activity emphasise the importance of total exercise volume above the significance of the duration of each bout. This study examined whether acute aerobic exercise changes circulating levels of IL-8 and MCP-1 and if these changes are associated with body composition and energy metabolism. Healthy adult volunteers completed a 10 min walking–running exercise on a treadmill. Indirect calorimetry was used to determine their resting metabolic rate (RMR) and energy expenditure (EE) during the exercise. Pre-exercise levels of IL-8 and MCP-1 were similar in both sexes. There were positive correlations of pre-exercise IL-8 with body mass, waist circumference, and lean body mass in men and pre-exercise MCP-1 with RMR in women. The exercise led to an increase in IL-8 of 68% and a decrease in MCP-1 of 74% of participants. An increase in post-exercise IL-8 in men was associated with greater walking EE and a greater increase in walking EE. The increase in post-exercise MCP-1 was associated with a lower RMR and running EE in women. There are both sex and individual variations in changes in chemokine secretion in response to the same exercise situation and their associations with values of metabolic parameters.https://www.mdpi.com/1422-0067/24/19/14725IL-8MCP-1aerobic exercisemetabolism |
| spellingShingle | Rudite Lagzdina Maija Rumaka Gita Gersone Peteris Tretjakovs Circulating Levels of IL-8 and MCP-1 in Healthy Adults: Changes after an Acute Aerobic Exercise and Association with Body Composition and Energy Metabolism International Journal of Molecular Sciences IL-8 MCP-1 aerobic exercise metabolism |
| title | Circulating Levels of IL-8 and MCP-1 in Healthy Adults: Changes after an Acute Aerobic Exercise and Association with Body Composition and Energy Metabolism |
| title_full | Circulating Levels of IL-8 and MCP-1 in Healthy Adults: Changes after an Acute Aerobic Exercise and Association with Body Composition and Energy Metabolism |
| title_fullStr | Circulating Levels of IL-8 and MCP-1 in Healthy Adults: Changes after an Acute Aerobic Exercise and Association with Body Composition and Energy Metabolism |
| title_full_unstemmed | Circulating Levels of IL-8 and MCP-1 in Healthy Adults: Changes after an Acute Aerobic Exercise and Association with Body Composition and Energy Metabolism |
| title_short | Circulating Levels of IL-8 and MCP-1 in Healthy Adults: Changes after an Acute Aerobic Exercise and Association with Body Composition and Energy Metabolism |
| title_sort | circulating levels of il 8 and mcp 1 in healthy adults changes after an acute aerobic exercise and association with body composition and energy metabolism |
| topic | IL-8 MCP-1 aerobic exercise metabolism |
| url | https://www.mdpi.com/1422-0067/24/19/14725 |
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