3′dNTP Binding Is Modulated during Primer Synthesis and Translesion by Human PrimPol

3′dNTP Binding Is Modulated during Primer Synthesis and Translesion by Human PrimPol

PrimPol is a DNA primase/polymerase from the Archaeo-Eukaryotic Primase (AEP) superfamily that enables the progression of stalled replication forks by synthesizing DNA primers ahead of blocking lesions or abnormal structures in the ssDNA template. PrimPol’s active site is formed by three AEP-conserv...

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Bibliographic Details
Main Authors:	Cristina Velázquez-Ruiz, Luis Blanco, María Isabel Martínez-Jiménez
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Series:	International Journal of Molecular Sciences
Subjects:	AEP human PrimPol AEP motif B 3′site dNTP ligands TLS
Online Access:	https://www.mdpi.com/1422-0067/25/1/51

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