Correlation of interleukin 6 (IL-6) with estrogen and progesterone receptor expression in breast cancer patients
Background: Multifunctional cytokines play important and only partially defined roles in mammary tumor development and progression. Normal human mammary epithelial cells constitutively produce interleukin 6(IL-6) and a non-secreted form of tumor necrosis factor. Transformation of mammary epithelial...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2011-01-01
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| Series: | مجلة كلية الطب |
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| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/952 |
| _version_ | 1827361849367068672 |
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| author | Amal K. Chaloob |
| author_facet | Amal K. Chaloob |
| author_sort | Amal K. Chaloob |
| collection | DOAJ |
| description | Background: Multifunctional cytokines play important and only partially defined roles in mammary tumor development and progression. Normal human mammary epithelial cells constitutively produce interleukin 6(IL-6) and a non-secreted form of tumor necrosis factor. Transformation of mammary epithelial cells by different oncogenesis is frequently associated with alterations of cytokine/ growth factor production and responsiveness.
Methods: We measured levels of 1L-6 in 84 females with breast cancer and examined their correlation with clinicopathological variables including stages of the disease and estrogen and
progesterone receptor expression on tumor cell.
Results: Our results revealed significantly higher serum IL-6 in breast cancer patients (12.98 pg/ml) compared to a healthy group (2.05pg/ml) (P<0.05) and a direct association with different clinical stages. And we found that expression of this cytokine was inversely associated with estrogen and progesterone receptor cells.
Conclusion: Serum levels of IL-6 are highly elevated in breast cancer patients and correlate with tumor progression. Assay for serum levels IL-6 can be used as predictive non-invasive tests for tumor progression in breast cancer patients; also our data suggest that cytokine could be involved in the aggressiveness of ER-PR negative breast tumors. Expression of interleukin 6(IL-6) correlates with estrogen and progesterone receptor in breast cancer patients. |
| first_indexed | 2024-03-08T07:13:26Z |
| format | Article |
| id | doaj.art-5e3952883e4e4477b30385cdd6f93967 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T07:13:26Z |
| publishDate | 2011-01-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-5e3952883e4e4477b30385cdd6f939672024-02-03T01:48:08ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572011-01-0152410.32007/jfacmedbagdad.v4438-440%Correlation of interleukin 6 (IL-6) with estrogen and progesterone receptor expression in breast cancer patientsAmal K. Chaloob0Dept. of Basic Science, College of Dentistry, Al- Mustansiriyah University.Background: Multifunctional cytokines play important and only partially defined roles in mammary tumor development and progression. Normal human mammary epithelial cells constitutively produce interleukin 6(IL-6) and a non-secreted form of tumor necrosis factor. Transformation of mammary epithelial cells by different oncogenesis is frequently associated with alterations of cytokine/ growth factor production and responsiveness. Methods: We measured levels of 1L-6 in 84 females with breast cancer and examined their correlation with clinicopathological variables including stages of the disease and estrogen and progesterone receptor expression on tumor cell. Results: Our results revealed significantly higher serum IL-6 in breast cancer patients (12.98 pg/ml) compared to a healthy group (2.05pg/ml) (P<0.05) and a direct association with different clinical stages. And we found that expression of this cytokine was inversely associated with estrogen and progesterone receptor cells. Conclusion: Serum levels of IL-6 are highly elevated in breast cancer patients and correlate with tumor progression. Assay for serum levels IL-6 can be used as predictive non-invasive tests for tumor progression in breast cancer patients; also our data suggest that cytokine could be involved in the aggressiveness of ER-PR negative breast tumors. Expression of interleukin 6(IL-6) correlates with estrogen and progesterone receptor in breast cancer patients.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/952Interleukin 6, breast cancer, estrogen-progesterone receptor |
| spellingShingle | Amal K. Chaloob Correlation of interleukin 6 (IL-6) with estrogen and progesterone receptor expression in breast cancer patients مجلة كلية الطب Interleukin 6, breast cancer, estrogen-progesterone receptor |
| title | Correlation of interleukin 6 (IL-6) with estrogen and progesterone receptor expression in breast cancer patients |
| title_full | Correlation of interleukin 6 (IL-6) with estrogen and progesterone receptor expression in breast cancer patients |
| title_fullStr | Correlation of interleukin 6 (IL-6) with estrogen and progesterone receptor expression in breast cancer patients |
| title_full_unstemmed | Correlation of interleukin 6 (IL-6) with estrogen and progesterone receptor expression in breast cancer patients |
| title_short | Correlation of interleukin 6 (IL-6) with estrogen and progesterone receptor expression in breast cancer patients |
| title_sort | correlation of interleukin 6 il 6 with estrogen and progesterone receptor expression in breast cancer patients |
| topic | Interleukin 6, breast cancer, estrogen-progesterone receptor |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/952 |
| work_keys_str_mv | AT amalkchaloob correlationofinterleukin6il6withestrogenandprogesteronereceptorexpressioninbreastcancerpatients |