Critical limb ischemia in a patient with systemic lupus erythematosus: a case report
Abstract Background Peripheral vascular disease is the rarest vascular complication in systemic lupus erythematosus. Some theories propose that immune complexes may promote inflammation in the vessel, and disrupt it in a manner that may cause ischemia. Case presentation A 14-year-old Asian girl pres...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13256-019-2024-9 |
| _version_ | 1811214589024534528 |
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| author | Vito Damay Wendy Wiharja Raymond Pranata Melisa Aziz |
| author_facet | Vito Damay Wendy Wiharja Raymond Pranata Melisa Aziz |
| author_sort | Vito Damay |
| collection | DOAJ |
| description | Abstract Background Peripheral vascular disease is the rarest vascular complication in systemic lupus erythematosus. Some theories propose that immune complexes may promote inflammation in the vessel, and disrupt it in a manner that may cause ischemia. Case presentation A 14-year-old Asian girl presented with intermittent claudication as the chief complaint followed by discoloration of her left big toe for 2 weeks prior to admission. Her medical history showed that 1 month prior to admission she had photosensitivity, rash, and arthralgia, with positive antinuclear antibody test, positive anti-double-stranded DNA test, positive anti-ribosomal protein P, and complement C4 (7.4 mg/dL); she was diagnosed as having systemic lupus erythematosus and started therapy. A local examination of her left toe showed black discoloration, low pulsation, localized tenderness, and decreased sensation. Laboratory results showed C-reactive protein of 1.16 mg/dL and D-dimer of 2.28 uG/mL. A computed tomography angiogram showed near total occlusion of her popliteal artery; critical limb ischemia was confirmed. Peripheral arteriography was performed with invasive strategy. After the procedure, the flow was improved to distal, but there was inflammation in the vessel, so we decided to stop the procedure because of the risk of dissection. Our patient was given atorvastatin and warfarin, and we maximized her systemic lupus erythematosus therapy with prednisone. There were two follow-ups. The first follow-up was 1 week after the procedure. Our patient attended her first follow-up at our out-patient department with no symptoms and improvement in her toe’s discoloration; warfarin was stopped, and clopidogrel and cilostazol were added for thrombus prevention therapy, she was then scheduled for debridement. The second follow-up was done 2 months after the first follow-up and discoloration was improved. The third follow-up, 5 months after the second follow-up, showed improvement. Conclusion Critical limb ischemia is a rare complication of systemic lupus erythematosus that requires immediate treatment. Due to our limited resources, we improvised a strategy to achieve the best possible outcome in our patient by using a combination of invasive treatment and medication. |
| first_indexed | 2024-04-12T06:07:13Z |
| format | Article |
| id | doaj.art-5e3aadc363774d23b89acfcee2b0bad1 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-12T06:07:13Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-5e3aadc363774d23b89acfcee2b0bad12022-12-22T03:44:49ZengBMCJournal of Medical Case Reports1752-19472019-04-011311710.1186/s13256-019-2024-9Critical limb ischemia in a patient with systemic lupus erythematosus: a case reportVito Damay0Wendy Wiharja1Raymond Pranata2Melisa Aziz3Department of Cardiovascular, Siloam Hospital Lippo VillageFaculty of Medicine, Universitas Pelita HarapanFaculty of Medicine, Universitas Pelita HarapanDepartment of Cardiovascular, Siloam Hospital Lippo VillageAbstract Background Peripheral vascular disease is the rarest vascular complication in systemic lupus erythematosus. Some theories propose that immune complexes may promote inflammation in the vessel, and disrupt it in a manner that may cause ischemia. Case presentation A 14-year-old Asian girl presented with intermittent claudication as the chief complaint followed by discoloration of her left big toe for 2 weeks prior to admission. Her medical history showed that 1 month prior to admission she had photosensitivity, rash, and arthralgia, with positive antinuclear antibody test, positive anti-double-stranded DNA test, positive anti-ribosomal protein P, and complement C4 (7.4 mg/dL); she was diagnosed as having systemic lupus erythematosus and started therapy. A local examination of her left toe showed black discoloration, low pulsation, localized tenderness, and decreased sensation. Laboratory results showed C-reactive protein of 1.16 mg/dL and D-dimer of 2.28 uG/mL. A computed tomography angiogram showed near total occlusion of her popliteal artery; critical limb ischemia was confirmed. Peripheral arteriography was performed with invasive strategy. After the procedure, the flow was improved to distal, but there was inflammation in the vessel, so we decided to stop the procedure because of the risk of dissection. Our patient was given atorvastatin and warfarin, and we maximized her systemic lupus erythematosus therapy with prednisone. There were two follow-ups. The first follow-up was 1 week after the procedure. Our patient attended her first follow-up at our out-patient department with no symptoms and improvement in her toe’s discoloration; warfarin was stopped, and clopidogrel and cilostazol were added for thrombus prevention therapy, she was then scheduled for debridement. The second follow-up was done 2 months after the first follow-up and discoloration was improved. The third follow-up, 5 months after the second follow-up, showed improvement. Conclusion Critical limb ischemia is a rare complication of systemic lupus erythematosus that requires immediate treatment. Due to our limited resources, we improvised a strategy to achieve the best possible outcome in our patient by using a combination of invasive treatment and medication.http://link.springer.com/article/10.1186/s13256-019-2024-9Critical limb ischemiaSystemic lupus erythematosusImmune complexPeripheral angioplasty |
| spellingShingle | Vito Damay Wendy Wiharja Raymond Pranata Melisa Aziz Critical limb ischemia in a patient with systemic lupus erythematosus: a case report Journal of Medical Case Reports Critical limb ischemia Systemic lupus erythematosus Immune complex Peripheral angioplasty |
| title | Critical limb ischemia in a patient with systemic lupus erythematosus: a case report |
| title_full | Critical limb ischemia in a patient with systemic lupus erythematosus: a case report |
| title_fullStr | Critical limb ischemia in a patient with systemic lupus erythematosus: a case report |
| title_full_unstemmed | Critical limb ischemia in a patient with systemic lupus erythematosus: a case report |
| title_short | Critical limb ischemia in a patient with systemic lupus erythematosus: a case report |
| title_sort | critical limb ischemia in a patient with systemic lupus erythematosus a case report |
| topic | Critical limb ischemia Systemic lupus erythematosus Immune complex Peripheral angioplasty |
| url | http://link.springer.com/article/10.1186/s13256-019-2024-9 |
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