Pharmacokinetic Modeling to Guide Preclinical Development of an Islatravir-Eluting Reservoir-Style Biodegradable Implant for Long-Acting HIV PrEP

Pharmacokinetic Modeling to Guide Preclinical Development of an Islatravir-Eluting Reservoir-Style Biodegradable Implant for Long-Acting HIV PrEP

Long-acting injectable cabotegravir is more effective than daily oral PrEP at preventing HIV transmission due to improved adherence, but requires bi-monthly large-volume intramuscular injections. Subcutaneous (SC) contraceptive implants can be formulated with antiretrovirals for extended-duration HI...

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Bibliographic Details
Main Authors: Talisa S. Kinsale, Mackenzie L. Cottrell, Linying Li, Rhonda Brand, Greg Gatto, Ellen Luecke, Chasity Norton, Archana Krovi, Julie B. Dumond, Gauri Rao, Shekhar Yeshwante, Brian Van Horne, Ariane Van Der Straten, Angela D. M. Kashuba, Leah M. Johnson
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceutics
Subjects:
HIV prevention
preexposure prophylaxis
antiretroviral agents
islatravir
extended-duration
long-acting implant
Online Access:https://www.mdpi.com/1999-4923/16/2/201

Internet

https://www.mdpi.com/1999-4923/16/2/201

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