Extracts Have Cytotoxic and Migration-Inhibitory Effects in Breast Cancer Cell Lines
Plants from the Bursera genus are widely distributed in the tropical dry forests of Mexico. In traditional medicine, extracts from different species of Bursera have been used for a wide range of biological activities, including the treatment of cancer-related symptoms. Compounds present in the Burse...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-09-01
|
| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/1534735418766416 |
| _version_ | 1828951829104295936 |
|---|---|
| author | Fabiola Domínguez PhD Paola Maycotte PhD Adilene Acosta-Casique BSc Sofía Rodríguez-Rodríguez MSc Diego A. Moreno PhD Federico Ferreres PhD Juan Carlos Flores-Alonso MSc María Guadalupe Delgado-López BSc Martín Pérez-Santos PhD Maricruz Anaya-Ruiz PhD |
| author_facet | Fabiola Domínguez PhD Paola Maycotte PhD Adilene Acosta-Casique BSc Sofía Rodríguez-Rodríguez MSc Diego A. Moreno PhD Federico Ferreres PhD Juan Carlos Flores-Alonso MSc María Guadalupe Delgado-López BSc Martín Pérez-Santos PhD Maricruz Anaya-Ruiz PhD |
| author_sort | Fabiola Domínguez PhD |
| collection | DOAJ |
| description | Plants from the Bursera genus are widely distributed in the tropical dry forests of Mexico. In traditional medicine, extracts from different species of Bursera have been used for a wide range of biological activities, including the treatment of cancer-related symptoms. Compounds present in the Bursera genus include lignans, flavonoids, steroids, short-chain aliphatic alkanes, acetates, alcohols, ketones, and terpenoids. In some instances, secondary metabolites of these classes of compounds may induce cytotoxicity, and therefore we sought to investigate the effects of B. copallifera leaf extracts in breast cancer cell lines to evaluate their potential therapeutic value for the treatment of breast cancer, one of the most prevalent types of cancer in women worldwide. Two B. copallifera leaf extracts exerted cytotoxic effects on both the MCF7 and MDA-MB-231 breast cancer cell line models. The cytotoxic effect was more evident in the MDA-MB-231 triple negative cell line inhibiting also the migration of these cells. We identified hydroxycinnamic acid and flavonol derivatives as major phenolic components of the extracts. Our results strongly suggest a potential use of the Bursera leaf extracts rich in phenolic compounds, their individual phenolic compounds, or their combinations for the treatment of breast cancer. |
| first_indexed | 2024-12-14T06:44:30Z |
| format | Article |
| id | doaj.art-5e3b5290d4a74c6da119640c5ed855fb |
| institution | Directory Open Access Journal |
| issn | 1552-695X |
| language | English |
| last_indexed | 2024-12-14T06:44:30Z |
| publishDate | 2018-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-5e3b5290d4a74c6da119640c5ed855fb2022-12-21T23:13:07ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2018-09-011710.1177/1534735418766416Extracts Have Cytotoxic and Migration-Inhibitory Effects in Breast Cancer Cell LinesFabiola Domínguez PhD0Paola Maycotte PhD1Adilene Acosta-Casique BSc2Sofía Rodríguez-Rodríguez MSc3Diego A. Moreno PhD4Federico Ferreres PhD5Juan Carlos Flores-Alonso MSc6María Guadalupe Delgado-López BSc7Martín Pérez-Santos PhD8Maricruz Anaya-Ruiz PhD9Instituto Mexicano del Seguro Social, Atlixco, Puebla, MexicoInstituto Mexicano del Seguro Social, Atlixco, Puebla, MexicoInstituto Mexicano del Seguro Social, Atlixco, Puebla, MexicoInstituto Mexicano del Seguro Social, Atlixco, Puebla, MexicoCampus Universitario Espinardo-25, Murcia, Espinardo, SpainCampus Universitario Espinardo-25, Murcia, Espinardo, SpainInstituto Mexicano del Seguro Social, Atlixco, Puebla, MexicoInstituto Mexicano del Seguro Social, Atlixco, Puebla, MexicoBenemérita Universidad Autónoma de Puebla, Atlixco, Puebla, MexicoInstituto Mexicano del Seguro Social, Atlixco, Puebla, MexicoPlants from the Bursera genus are widely distributed in the tropical dry forests of Mexico. In traditional medicine, extracts from different species of Bursera have been used for a wide range of biological activities, including the treatment of cancer-related symptoms. Compounds present in the Bursera genus include lignans, flavonoids, steroids, short-chain aliphatic alkanes, acetates, alcohols, ketones, and terpenoids. In some instances, secondary metabolites of these classes of compounds may induce cytotoxicity, and therefore we sought to investigate the effects of B. copallifera leaf extracts in breast cancer cell lines to evaluate their potential therapeutic value for the treatment of breast cancer, one of the most prevalent types of cancer in women worldwide. Two B. copallifera leaf extracts exerted cytotoxic effects on both the MCF7 and MDA-MB-231 breast cancer cell line models. The cytotoxic effect was more evident in the MDA-MB-231 triple negative cell line inhibiting also the migration of these cells. We identified hydroxycinnamic acid and flavonol derivatives as major phenolic components of the extracts. Our results strongly suggest a potential use of the Bursera leaf extracts rich in phenolic compounds, their individual phenolic compounds, or their combinations for the treatment of breast cancer.https://doi.org/10.1177/1534735418766416 |
| spellingShingle | Fabiola Domínguez PhD Paola Maycotte PhD Adilene Acosta-Casique BSc Sofía Rodríguez-Rodríguez MSc Diego A. Moreno PhD Federico Ferreres PhD Juan Carlos Flores-Alonso MSc María Guadalupe Delgado-López BSc Martín Pérez-Santos PhD Maricruz Anaya-Ruiz PhD Extracts Have Cytotoxic and Migration-Inhibitory Effects in Breast Cancer Cell Lines Integrative Cancer Therapies |
| title | Extracts Have Cytotoxic and Migration-Inhibitory Effects in Breast Cancer Cell Lines |
| title_full | Extracts Have Cytotoxic and Migration-Inhibitory Effects in Breast Cancer Cell Lines |
| title_fullStr | Extracts Have Cytotoxic and Migration-Inhibitory Effects in Breast Cancer Cell Lines |
| title_full_unstemmed | Extracts Have Cytotoxic and Migration-Inhibitory Effects in Breast Cancer Cell Lines |
| title_short | Extracts Have Cytotoxic and Migration-Inhibitory Effects in Breast Cancer Cell Lines |
| title_sort | extracts have cytotoxic and migration inhibitory effects in breast cancer cell lines |
| url | https://doi.org/10.1177/1534735418766416 |
| work_keys_str_mv | AT fabioladominguezphd extractshavecytotoxicandmigrationinhibitoryeffectsinbreastcancercelllines AT paolamaycottephd extractshavecytotoxicandmigrationinhibitoryeffectsinbreastcancercelllines AT adileneacostacasiquebsc extractshavecytotoxicandmigrationinhibitoryeffectsinbreastcancercelllines AT sofiarodriguezrodriguezmsc extractshavecytotoxicandmigrationinhibitoryeffectsinbreastcancercelllines AT diegoamorenophd extractshavecytotoxicandmigrationinhibitoryeffectsinbreastcancercelllines AT federicoferreresphd extractshavecytotoxicandmigrationinhibitoryeffectsinbreastcancercelllines AT juancarlosfloresalonsomsc extractshavecytotoxicandmigrationinhibitoryeffectsinbreastcancercelllines AT mariaguadalupedelgadolopezbsc extractshavecytotoxicandmigrationinhibitoryeffectsinbreastcancercelllines AT martinperezsantosphd extractshavecytotoxicandmigrationinhibitoryeffectsinbreastcancercelllines AT maricruzanayaruizphd extractshavecytotoxicandmigrationinhibitoryeffectsinbreastcancercelllines |