Primary Pulmonary B-Cell Lymphoma: A Review and Update
Primary pulmonary B-cell lymphomas (PP-BCLs) comprise a group of extranodal non-Hodgkin lymphomas of B-cell origin, which primarily affect the lung without evidence of extrapulmonary disease at the time of diagnosis and up to 3 months afterwards. Primary lymphoid proliferations of the lung are most...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/3/415 |
| _version_ | 1797408304100540416 |
|---|---|
| author | Francesca Sanguedolce Magda Zanelli Maurizio Zizzo Alessandra Bisagni Alessandra Soriano Giorgia Cocco Andrea Palicelli Giacomo Santandrea Cecilia Caprera Matteo Corsi Giulia Cerrone Raffaele Sciaccotta Giovanni Martino Linda Ricci Francesco Sollitto Domenico Loizzi Stefano Ascani |
| author_facet | Francesca Sanguedolce Magda Zanelli Maurizio Zizzo Alessandra Bisagni Alessandra Soriano Giorgia Cocco Andrea Palicelli Giacomo Santandrea Cecilia Caprera Matteo Corsi Giulia Cerrone Raffaele Sciaccotta Giovanni Martino Linda Ricci Francesco Sollitto Domenico Loizzi Stefano Ascani |
| author_sort | Francesca Sanguedolce |
| collection | DOAJ |
| description | Primary pulmonary B-cell lymphomas (PP-BCLs) comprise a group of extranodal non-Hodgkin lymphomas of B-cell origin, which primarily affect the lung without evidence of extrapulmonary disease at the time of diagnosis and up to 3 months afterwards. Primary lymphoid proliferations of the lung are most often of B-cell lineage, and include three major entities with different clinical, morphological, and molecular features: primary pulmonary marginal zone lymphoma of mucosa-associated lymphoid tissue (PP-MZL, or MALT lymphoma), primary pulmonary diffuse large B cell lymphoma (PP-DLBCL), and lymphomatoid granulomatosis (LYG). Less common entities include primary effusion B-cell lymphoma (PEL) and intravascular large B cell lymphoma (IVLBCL). A proper workup requires a multidisciplinary approach, including radiologists, pneumologists, thoracic surgeons, pathologists, hemato-oncologists, and radiation oncologists, in order to achieve a correct diagnosis and risk assessment. Aim of this review is to analyze and outline the clinical and pathological features of the most frequent PP-BCLs, and to critically analyze the major issues in their diagnosis and management. |
| first_indexed | 2024-03-09T03:57:28Z |
| format | Article |
| id | doaj.art-5e3cc684585c4cb1b8053eded5bc6db9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T03:57:28Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5e3cc684585c4cb1b8053eded5bc6db92023-12-03T14:18:51ZengMDPI AGCancers2072-66942021-01-0113341510.3390/cancers13030415Primary Pulmonary B-Cell Lymphoma: A Review and UpdateFrancesca Sanguedolce0Magda Zanelli1Maurizio Zizzo2Alessandra Bisagni3Alessandra Soriano4Giorgia Cocco5Andrea Palicelli6Giacomo Santandrea7Cecilia Caprera8Matteo Corsi9Giulia Cerrone10Raffaele Sciaccotta11Giovanni Martino12Linda Ricci13Francesco Sollitto14Domenico Loizzi15Stefano Ascani16Pathology Unit, Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Foggia, 71122 Foggia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalySurgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyGastroenterology, Division and Inflammatory Bowel Disease Center, Department of Internal Medicine, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyRadiotherapy Unit, Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Foggia, 71122 Foggia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyPathology Unit, Azienda Ospedaliera S. Maria di Terni, University of Perugia, 05100 Terni, ItalyPathology Unit, Azienda Ospedaliera S. Maria di Terni, University of Perugia, 05100 Terni, ItalyPathology Unit, Azienda Ospedaliera S. Maria di Terni, University of Perugia, 05100 Terni, ItalyPathology Unit, Azienda Ospedaliera S. Maria di Terni, University of Perugia, 05100 Terni, ItalyPathology Unit, Azienda Ospedaliera S. Maria di Terni, University of Perugia, 05100 Terni, ItalyPathology Unit, Azienda Ospedaliera S. Maria di Terni, University of Perugia, 05100 Terni, ItalyInstitute of Thoracic Surgery, University of Foggia, 71122 Foggia, ItalyInstitute of Thoracic Surgery, University of Foggia, 71122 Foggia, ItalyPathology Unit, Azienda Ospedaliera S. Maria di Terni, University of Perugia, 05100 Terni, ItalyPrimary pulmonary B-cell lymphomas (PP-BCLs) comprise a group of extranodal non-Hodgkin lymphomas of B-cell origin, which primarily affect the lung without evidence of extrapulmonary disease at the time of diagnosis and up to 3 months afterwards. Primary lymphoid proliferations of the lung are most often of B-cell lineage, and include three major entities with different clinical, morphological, and molecular features: primary pulmonary marginal zone lymphoma of mucosa-associated lymphoid tissue (PP-MZL, or MALT lymphoma), primary pulmonary diffuse large B cell lymphoma (PP-DLBCL), and lymphomatoid granulomatosis (LYG). Less common entities include primary effusion B-cell lymphoma (PEL) and intravascular large B cell lymphoma (IVLBCL). A proper workup requires a multidisciplinary approach, including radiologists, pneumologists, thoracic surgeons, pathologists, hemato-oncologists, and radiation oncologists, in order to achieve a correct diagnosis and risk assessment. Aim of this review is to analyze and outline the clinical and pathological features of the most frequent PP-BCLs, and to critically analyze the major issues in their diagnosis and management.https://www.mdpi.com/2072-6694/13/3/415pulmonary B-cell lymphomaBALTMALT lymphomadiffuse large B-cell lymphomalymphomatoid granulomatosisprimary effusion lymphoma |
| spellingShingle | Francesca Sanguedolce Magda Zanelli Maurizio Zizzo Alessandra Bisagni Alessandra Soriano Giorgia Cocco Andrea Palicelli Giacomo Santandrea Cecilia Caprera Matteo Corsi Giulia Cerrone Raffaele Sciaccotta Giovanni Martino Linda Ricci Francesco Sollitto Domenico Loizzi Stefano Ascani Primary Pulmonary B-Cell Lymphoma: A Review and Update Cancers pulmonary B-cell lymphoma BALT MALT lymphoma diffuse large B-cell lymphoma lymphomatoid granulomatosis primary effusion lymphoma |
| title | Primary Pulmonary B-Cell Lymphoma: A Review and Update |
| title_full | Primary Pulmonary B-Cell Lymphoma: A Review and Update |
| title_fullStr | Primary Pulmonary B-Cell Lymphoma: A Review and Update |
| title_full_unstemmed | Primary Pulmonary B-Cell Lymphoma: A Review and Update |
| title_short | Primary Pulmonary B-Cell Lymphoma: A Review and Update |
| title_sort | primary pulmonary b cell lymphoma a review and update |
| topic | pulmonary B-cell lymphoma BALT MALT lymphoma diffuse large B-cell lymphoma lymphomatoid granulomatosis primary effusion lymphoma |
| url | https://www.mdpi.com/2072-6694/13/3/415 |
| work_keys_str_mv | AT francescasanguedolce primarypulmonarybcelllymphomaareviewandupdate AT magdazanelli primarypulmonarybcelllymphomaareviewandupdate AT mauriziozizzo primarypulmonarybcelllymphomaareviewandupdate AT alessandrabisagni primarypulmonarybcelllymphomaareviewandupdate AT alessandrasoriano primarypulmonarybcelllymphomaareviewandupdate AT giorgiacocco primarypulmonarybcelllymphomaareviewandupdate AT andreapalicelli primarypulmonarybcelllymphomaareviewandupdate AT giacomosantandrea primarypulmonarybcelllymphomaareviewandupdate AT ceciliacaprera primarypulmonarybcelllymphomaareviewandupdate AT matteocorsi primarypulmonarybcelllymphomaareviewandupdate AT giuliacerrone primarypulmonarybcelllymphomaareviewandupdate AT raffaelesciaccotta primarypulmonarybcelllymphomaareviewandupdate AT giovannimartino primarypulmonarybcelllymphomaareviewandupdate AT lindaricci primarypulmonarybcelllymphomaareviewandupdate AT francescosollitto primarypulmonarybcelllymphomaareviewandupdate AT domenicoloizzi primarypulmonarybcelllymphomaareviewandupdate AT stefanoascani primarypulmonarybcelllymphomaareviewandupdate |