Burden of Antibiotic Resistance in Common Infectious Diseases: Role of Antibiotic Combination Therapy
Globally, antimicrobial resistance is alarming concern especially in commonly reported disease entities like respiratory tract infection, enteric fever and infections associated with gram-negative bacilli (GNB). Rational use of antimicrobial drugs reported significant decrease in bacterial burden a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4489/8778_F(H)_PF1(PAG)_PFA(P)_PFA(P)_PFA2(AK)_PFA3(AK).pdf |
| Summary: | Globally, antimicrobial resistance is alarming concern especially in commonly reported disease entities like respiratory tract infection, enteric
fever and infections associated with gram-negative bacilli (GNB). Rational use of antimicrobial drugs reported significant decrease in bacterial burden and may also reduce the risk of disease progression. However, at times in particular indication, certain patient and pathogen
factor limits the selection and use of specific antibiotic therapy while in some case, due to presence of additional risk factor, aggressive
therapy is required to achieve clinical reemission and prevent complications. Delay in start of suitable antibiotic therapy is another imperative
factor for treatment failure and rise of drug resistance.
With rapidly increasing antibiotic resistance and decline in new antibiotic drug development, the toughest challenge remains to maintain and
preserve the efficacy of currently available antibiotics. Therefore, the best rational approach to fight these infections is to ‘hit early and hit
hard’ and kills drug-susceptible bacteria before they become resistant. The preferred approach is to deploy two antibiotics that produce a
stronger effect in combination than if either drug were used alone. Various society guidelines in particular indications also justify and recommend the use of combination of antimicrobial therapy. Combination therapies have distinct advantage over monotherapy in terms of broad
coverage, synergistic effect and prevention of emergence of drug resistance. |
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| ISSN: | 2249-782X 0973-709X |