Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of <i>N</i>-alkyl-acridones and <i>N</i>,<i>N′</i>-dialkyl-9,9′-biacridylidenes

Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of <i>N</i>-alkyl-acridones and <i>N</i>,<i>N′</i>-dialkyl-9,9′-biacridylidenes

The anticancer activity of acridone derivatives has attracted increasing interest, therefore, a variety of substituted analogs belonging to this family have been developed and evaluated for their anti-cancer properties. A series of <i>N</i>-alkyl-acridones <b>1</b>&#8722;...

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Bibliographic Details
Main Authors: Marios G. Krokidis, Zara Molphy, Eleni K. Efthimiadou, Marianna Kokoli, Smaragda-Maria Argyri, Irini Dousi, Annalisa Masi, Kyriakos Papadopoulos, Andrew Kellett, Chryssostomos Chatgilialoglu
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Biomolecules
Subjects:
<i>N</i>,<i>N′</i>-dialkyl-9,9′-biacridylidenes
topoisomerase I
DNA intercalation
DNA binding
radical scavenging capacity
cytotoxic activity
Online Access:https://www.mdpi.com/2218-273X/9/5/177

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