Accidental organophosphate poisoning: A case series of 2 pediatric coumaphos exposures
Abstract Introduction Pediatric organophosphate insecticide poisonings are rare in the United States, and life‐threatening toxicity is rarely seen. We report 2 accidental ingestions of the organophosphate insecticide coumaphos that resulted in life‐threatening symptoms. Case Reports A 7‐year‐old boy...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-12-01
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| Series: | Journal of the American College of Emergency Physicians Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/emp2.12859 |
| _version_ | 1797835945794338816 |
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| author | Justin A. Seltzer Sarah Friedland Nathan A. Friedman Garret A. Winkler Emily Foreman Yousef Al Mubarak Brent Buccine Branden Engorn Allyson Kreshak Alicia Minns Christian A. Tomaszewski Daniel R. Lasoff Richard F. Clark |
| author_facet | Justin A. Seltzer Sarah Friedland Nathan A. Friedman Garret A. Winkler Emily Foreman Yousef Al Mubarak Brent Buccine Branden Engorn Allyson Kreshak Alicia Minns Christian A. Tomaszewski Daniel R. Lasoff Richard F. Clark |
| author_sort | Justin A. Seltzer |
| collection | DOAJ |
| description | Abstract Introduction Pediatric organophosphate insecticide poisonings are rare in the United States, and life‐threatening toxicity is rarely seen. We report 2 accidental ingestions of the organophosphate insecticide coumaphos that resulted in life‐threatening symptoms. Case Reports A 7‐year‐old boy and 10‐year‐old girl both presented from home after accidental ingestion of 1 “spoonful” of coumaphos 20% liquid (Asuntol; Bayer de Mexico, S.A. de C.V., Mexico D.F., Mexico). There were no other known ingestions. Both became rapidly symptomatic, with the boy developing dyspnea, vomiting, and depressed mental status and the girl developing headache and nausea. Soon afterward, the boy had witnessed cardiopulmonary arrest and the girl developed altered mental status and flaccid paralysis. Both were treated initially with atropine, but required no additional doses. On arrival to the pediatric intensive care unit (ICU), both patients received pralidoxime with subsequent plasma exchange and continuous venovenous hemodiafiltration (CVVHDF). Transient anemia, coagulopathy, transaminitis, and hyperglycemia developed in both patients. The girl was extubated on hospital day 6 and the boy on hospital day 11. The girl's course was complicated by aspiration pneumonia and an isolated seizure. The boy's course was complicated mainly by anoxic brain injury, associated seizures, neuroagitation, spasticity, and autonomic instability. The girl was discharged on hospital day 16 and remains asymptomatic 32 days after ingestion. As of 90 days after ingestion, the boy remains admitted to inpatient rehabilitation. Discussion The clinical benefit of pralidoxime, plasma exchange, and CVVHDF is uncertain in these cases. The optimal treatment regimen for organophosphate insecticide toxicity remains poorly defined. |
| first_indexed | 2024-04-09T15:00:44Z |
| format | Article |
| id | doaj.art-5e407414707040bb9ebc7f7070bf027a |
| institution | Directory Open Access Journal |
| issn | 2688-1152 |
| language | English |
| last_indexed | 2024-04-09T15:00:44Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American College of Emergency Physicians Open |
| spelling | doaj.art-5e407414707040bb9ebc7f7070bf027a2023-05-01T17:36:03ZengWileyJournal of the American College of Emergency Physicians Open2688-11522022-12-0136n/an/a10.1002/emp2.12859Accidental organophosphate poisoning: A case series of 2 pediatric coumaphos exposuresJustin A. Seltzer0Sarah Friedland1Nathan A. Friedman2Garret A. Winkler3Emily Foreman4Yousef Al Mubarak5Brent Buccine6Branden Engorn7Allyson Kreshak8Alicia Minns9Christian A. Tomaszewski10Daniel R. Lasoff11Richard F. Clark12Division of Medical Toxicology Department of Emergency Medicine UC San Diego Health San Diego California USARady Children's Hospital San Diego San Diego California USADivision of Medical Toxicology Department of Emergency Medicine UC San Diego Health San Diego California USADivision of Medical Toxicology Department of Emergency Medicine UC San Diego Health San Diego California USARady Children's Hospital San Diego San Diego California USAEmergency Medicine Department King Fahad Medical City Riyadh Saudi ArabiaDepartment of Emergency Medicine Naval Medical Center San Diego San Diego California USARady Children's Hospital San Diego San Diego California USADivision of Medical Toxicology Department of Emergency Medicine UC San Diego Health San Diego California USADivision of Medical Toxicology Department of Emergency Medicine UC San Diego Health San Diego California USADivision of Medical Toxicology Department of Emergency Medicine UC San Diego Health San Diego California USADivision of Medical Toxicology Department of Emergency Medicine UC San Diego Health San Diego California USADivision of Medical Toxicology Department of Emergency Medicine UC San Diego Health San Diego California USAAbstract Introduction Pediatric organophosphate insecticide poisonings are rare in the United States, and life‐threatening toxicity is rarely seen. We report 2 accidental ingestions of the organophosphate insecticide coumaphos that resulted in life‐threatening symptoms. Case Reports A 7‐year‐old boy and 10‐year‐old girl both presented from home after accidental ingestion of 1 “spoonful” of coumaphos 20% liquid (Asuntol; Bayer de Mexico, S.A. de C.V., Mexico D.F., Mexico). There were no other known ingestions. Both became rapidly symptomatic, with the boy developing dyspnea, vomiting, and depressed mental status and the girl developing headache and nausea. Soon afterward, the boy had witnessed cardiopulmonary arrest and the girl developed altered mental status and flaccid paralysis. Both were treated initially with atropine, but required no additional doses. On arrival to the pediatric intensive care unit (ICU), both patients received pralidoxime with subsequent plasma exchange and continuous venovenous hemodiafiltration (CVVHDF). Transient anemia, coagulopathy, transaminitis, and hyperglycemia developed in both patients. The girl was extubated on hospital day 6 and the boy on hospital day 11. The girl's course was complicated by aspiration pneumonia and an isolated seizure. The boy's course was complicated mainly by anoxic brain injury, associated seizures, neuroagitation, spasticity, and autonomic instability. The girl was discharged on hospital day 16 and remains asymptomatic 32 days after ingestion. As of 90 days after ingestion, the boy remains admitted to inpatient rehabilitation. Discussion The clinical benefit of pralidoxime, plasma exchange, and CVVHDF is uncertain in these cases. The optimal treatment regimen for organophosphate insecticide toxicity remains poorly defined.https://doi.org/10.1002/emp2.12859accidental ingestioncholinergiccritical careinsecticideorganophosphatepediatrics |
| spellingShingle | Justin A. Seltzer Sarah Friedland Nathan A. Friedman Garret A. Winkler Emily Foreman Yousef Al Mubarak Brent Buccine Branden Engorn Allyson Kreshak Alicia Minns Christian A. Tomaszewski Daniel R. Lasoff Richard F. Clark Accidental organophosphate poisoning: A case series of 2 pediatric coumaphos exposures Journal of the American College of Emergency Physicians Open accidental ingestion cholinergic critical care insecticide organophosphate pediatrics |
| title | Accidental organophosphate poisoning: A case series of 2 pediatric coumaphos exposures |
| title_full | Accidental organophosphate poisoning: A case series of 2 pediatric coumaphos exposures |
| title_fullStr | Accidental organophosphate poisoning: A case series of 2 pediatric coumaphos exposures |
| title_full_unstemmed | Accidental organophosphate poisoning: A case series of 2 pediatric coumaphos exposures |
| title_short | Accidental organophosphate poisoning: A case series of 2 pediatric coumaphos exposures |
| title_sort | accidental organophosphate poisoning a case series of 2 pediatric coumaphos exposures |
| topic | accidental ingestion cholinergic critical care insecticide organophosphate pediatrics |
| url | https://doi.org/10.1002/emp2.12859 |
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