A Wearable, Textile-Based Polyacrylate Imprinted Electrochemical Sensor for Cortisol Detection in Sweat
A wearable, textile-based molecularly imprinted polymer (MIP) electrochemical sensor for cortisol detection in human sweat has been demonstrated. The wearable cortisol sensor was fabricated via layer-by-layer assembly (LbL) on a flexible cotton textile substrate coated with a conductive nanoporous c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/12/10/854 |
| _version_ | 1797474779622539264 |
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| author | Samuel M. Mugo Weihao Lu Scott Robertson |
| author_facet | Samuel M. Mugo Weihao Lu Scott Robertson |
| author_sort | Samuel M. Mugo |
| collection | DOAJ |
| description | A wearable, textile-based molecularly imprinted polymer (MIP) electrochemical sensor for cortisol detection in human sweat has been demonstrated. The wearable cortisol sensor was fabricated via layer-by-layer assembly (LbL) on a flexible cotton textile substrate coated with a conductive nanoporous carbon nanotube/cellulose nanocrystal (CNT/CNC) composite suspension, conductive polyaniline (PANI), and a selective cortisol-imprinted poly(glycidylmethacrylate-co-ethylene glycol dimethacrylate) (poly(GMA-co-EGDMA)) decorated with gold nanoparticles (AuNPs), or plated with gold. The cortisol sensor rapidly (<2 min) responded to 9.8–49.5 ng/mL of cortisol, with an average relative standard deviation (%RSD) of 6.4% across the dynamic range, indicating excellent precision. The cortisol sensor yielded an excellent limit of detection (LOD) of 8.00 ng/mL, which is within the typical physiological levels in human sweat. A single cortisol sensor patch could be reused 15 times over a 30-day period with no loss in performance, attesting to excellent reusability. The cortisol sensor patch was successfully verified for use in quantification of cortisol levels in human sweat. |
| first_indexed | 2024-03-09T20:35:55Z |
| format | Article |
| id | doaj.art-5e41b286e87b447dba6c9654a2bc31c4 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T20:35:55Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-5e41b286e87b447dba6c9654a2bc31c42023-11-23T23:11:44ZengMDPI AGBiosensors2079-63742022-10-01121085410.3390/bios12100854A Wearable, Textile-Based Polyacrylate Imprinted Electrochemical Sensor for Cortisol Detection in SweatSamuel M. Mugo0Weihao Lu1Scott Robertson2Physical Sciences Department, MacEwan University, Edmonton, AB T5J4S2, CanadaPhysical Sciences Department, MacEwan University, Edmonton, AB T5J4S2, CanadaPhysical Sciences Department, MacEwan University, Edmonton, AB T5J4S2, CanadaA wearable, textile-based molecularly imprinted polymer (MIP) electrochemical sensor for cortisol detection in human sweat has been demonstrated. The wearable cortisol sensor was fabricated via layer-by-layer assembly (LbL) on a flexible cotton textile substrate coated with a conductive nanoporous carbon nanotube/cellulose nanocrystal (CNT/CNC) composite suspension, conductive polyaniline (PANI), and a selective cortisol-imprinted poly(glycidylmethacrylate-co-ethylene glycol dimethacrylate) (poly(GMA-co-EGDMA)) decorated with gold nanoparticles (AuNPs), or plated with gold. The cortisol sensor rapidly (<2 min) responded to 9.8–49.5 ng/mL of cortisol, with an average relative standard deviation (%RSD) of 6.4% across the dynamic range, indicating excellent precision. The cortisol sensor yielded an excellent limit of detection (LOD) of 8.00 ng/mL, which is within the typical physiological levels in human sweat. A single cortisol sensor patch could be reused 15 times over a 30-day period with no loss in performance, attesting to excellent reusability. The cortisol sensor patch was successfully verified for use in quantification of cortisol levels in human sweat.https://www.mdpi.com/2079-6374/12/10/854wearable capacitive sensorcortisol sensingmolecularly imprinted polymers (MIPs)polyacrylatee-skins |
| spellingShingle | Samuel M. Mugo Weihao Lu Scott Robertson A Wearable, Textile-Based Polyacrylate Imprinted Electrochemical Sensor for Cortisol Detection in Sweat Biosensors wearable capacitive sensor cortisol sensing molecularly imprinted polymers (MIPs) polyacrylate e-skins |
| title | A Wearable, Textile-Based Polyacrylate Imprinted Electrochemical Sensor for Cortisol Detection in Sweat |
| title_full | A Wearable, Textile-Based Polyacrylate Imprinted Electrochemical Sensor for Cortisol Detection in Sweat |
| title_fullStr | A Wearable, Textile-Based Polyacrylate Imprinted Electrochemical Sensor for Cortisol Detection in Sweat |
| title_full_unstemmed | A Wearable, Textile-Based Polyacrylate Imprinted Electrochemical Sensor for Cortisol Detection in Sweat |
| title_short | A Wearable, Textile-Based Polyacrylate Imprinted Electrochemical Sensor for Cortisol Detection in Sweat |
| title_sort | wearable textile based polyacrylate imprinted electrochemical sensor for cortisol detection in sweat |
| topic | wearable capacitive sensor cortisol sensing molecularly imprinted polymers (MIPs) polyacrylate e-skins |
| url | https://www.mdpi.com/2079-6374/12/10/854 |
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