Track-Density Ratio Mapping With Fiber Types in the Cerebral Cortex Using Diffusion-Weighted MRI
The nerve fibers are divided into three categories: projection, commissural, and association fibers. This study demonstrated a novel cortical mapping method based on these three fiber categories using MR tractography data. The MR fiber-track data were extracted using the diffusion-weighted 3T-MRI da...
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| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnana.2021.715571/full |
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| author | Sang-Han Choi Gangwon Jeong Young-Eun Hwang Yong-Bo Kim Haigun Lee Zang-Hee Cho Zang-Hee Cho |
| author_facet | Sang-Han Choi Gangwon Jeong Young-Eun Hwang Yong-Bo Kim Haigun Lee Zang-Hee Cho Zang-Hee Cho |
| author_sort | Sang-Han Choi |
| collection | DOAJ |
| description | The nerve fibers are divided into three categories: projection, commissural, and association fibers. This study demonstrated a novel cortical mapping method based on these three fiber categories using MR tractography data. The MR fiber-track data were extracted using the diffusion-weighted 3T-MRI data from 19 individuals’ Human Connectome Project dataset. Anatomical MR images in each dataset were parcellated using FreeSurfer software and Brainnetome atlas. The 5 million extracted tracks per subject by MRtrix software were classified based on the basic cortical structure (cortical area in the left and right hemisphere, subcortical area), after the tracks validation procedure. The number of terminals for each categorized track per unit-sized cortical area (1 mm3) was defined as the track-density in that cortical area. Track-density ratio mapping with fiber types was achieved by mapping the density-dependent color intensity for each categorized tracks with a different primary color. The mapping results showed a highly localized, unique density ratio map determined by fiber types. Furthermore, the quantitative group data analysis based on the parcellation information revealed that the majority of nerve fibers in the brain are association fibers, particularly in temporal, inferior parietal, and occipital lobes, while the projection and commissural fibers were mainly located in the superior part of the brain. Hemispheric asymmetries in the fiber density were also observed, such as long association fiber in the Broca’s and Wernicke’s areas. We believe this new dimensional brain mapping information allows us to further understand brain anatomy, function. |
| first_indexed | 2024-12-16T14:16:33Z |
| format | Article |
| id | doaj.art-5e41e02df29e445cbf4f474b4ed2e85d |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-16T14:16:33Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-5e41e02df29e445cbf4f474b4ed2e85d2022-12-21T22:28:35ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292021-07-011510.3389/fnana.2021.715571715571Track-Density Ratio Mapping With Fiber Types in the Cerebral Cortex Using Diffusion-Weighted MRISang-Han Choi0Gangwon Jeong1Young-Eun Hwang2Yong-Bo Kim3Haigun Lee4Zang-Hee Cho5Zang-Hee Cho6Neuroscience Convergence Center, Korea University, Seoul, South KoreaAICT, Seoul National University, Seoul, South KoreaNeuroscience Convergence Center, Korea University, Seoul, South KoreaNeuroscience Research Institute, Gachon University, Incheon, South KoreaGreen Manufacturing Research Center, Korea University, Seoul, South KoreaNeuroscience Convergence Center, Korea University, Seoul, South KoreaAICT, Seoul National University, Seoul, South KoreaThe nerve fibers are divided into three categories: projection, commissural, and association fibers. This study demonstrated a novel cortical mapping method based on these three fiber categories using MR tractography data. The MR fiber-track data were extracted using the diffusion-weighted 3T-MRI data from 19 individuals’ Human Connectome Project dataset. Anatomical MR images in each dataset were parcellated using FreeSurfer software and Brainnetome atlas. The 5 million extracted tracks per subject by MRtrix software were classified based on the basic cortical structure (cortical area in the left and right hemisphere, subcortical area), after the tracks validation procedure. The number of terminals for each categorized track per unit-sized cortical area (1 mm3) was defined as the track-density in that cortical area. Track-density ratio mapping with fiber types was achieved by mapping the density-dependent color intensity for each categorized tracks with a different primary color. The mapping results showed a highly localized, unique density ratio map determined by fiber types. Furthermore, the quantitative group data analysis based on the parcellation information revealed that the majority of nerve fibers in the brain are association fibers, particularly in temporal, inferior parietal, and occipital lobes, while the projection and commissural fibers were mainly located in the superior part of the brain. Hemispheric asymmetries in the fiber density were also observed, such as long association fiber in the Broca’s and Wernicke’s areas. We believe this new dimensional brain mapping information allows us to further understand brain anatomy, function.https://www.frontiersin.org/articles/10.3389/fnana.2021.715571/fullnerve fibersbrain mappingdiffusion-weighted MRIhuman connectome projecttractography |
| spellingShingle | Sang-Han Choi Gangwon Jeong Young-Eun Hwang Yong-Bo Kim Haigun Lee Zang-Hee Cho Zang-Hee Cho Track-Density Ratio Mapping With Fiber Types in the Cerebral Cortex Using Diffusion-Weighted MRI Frontiers in Neuroanatomy nerve fibers brain mapping diffusion-weighted MRI human connectome project tractography |
| title | Track-Density Ratio Mapping With Fiber Types in the Cerebral Cortex Using Diffusion-Weighted MRI |
| title_full | Track-Density Ratio Mapping With Fiber Types in the Cerebral Cortex Using Diffusion-Weighted MRI |
| title_fullStr | Track-Density Ratio Mapping With Fiber Types in the Cerebral Cortex Using Diffusion-Weighted MRI |
| title_full_unstemmed | Track-Density Ratio Mapping With Fiber Types in the Cerebral Cortex Using Diffusion-Weighted MRI |
| title_short | Track-Density Ratio Mapping With Fiber Types in the Cerebral Cortex Using Diffusion-Weighted MRI |
| title_sort | track density ratio mapping with fiber types in the cerebral cortex using diffusion weighted mri |
| topic | nerve fibers brain mapping diffusion-weighted MRI human connectome project tractography |
| url | https://www.frontiersin.org/articles/10.3389/fnana.2021.715571/full |
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