Genetic Interactions in Various Environmental Conditions in <i>Caenorhabditis elegans</i>
Although it is well known that epistasis plays an important role in many evolutionary processes (e.g., speciation, evolution of sex), our knowledge on the frequency and prevalent sign of epistatic interactions is mainly limited to unicellular organisms or cell cultures of multicellular organisms. Th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/14/11/2080 |
| _version_ | 1797459187766132736 |
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| author | Katarzyna Toch Mateusz Buczek Marta K. Labocha |
| author_facet | Katarzyna Toch Mateusz Buczek Marta K. Labocha |
| author_sort | Katarzyna Toch |
| collection | DOAJ |
| description | Although it is well known that epistasis plays an important role in many evolutionary processes (e.g., speciation, evolution of sex), our knowledge on the frequency and prevalent sign of epistatic interactions is mainly limited to unicellular organisms or cell cultures of multicellular organisms. This is even more pronounced in regard to how the environment can influence genetic interactions. To broaden our knowledge in that respect we studied gene–gene interactions in a whole multicellular organism, <i>Caenorhabditis elegans</i>. We screened over one thousand gene interactions, each one in standard laboratory conditions, and under three different stressors: heat shock, oxidative stress, and genotoxic stress. Depending on the condition, between 7% and 22% of gene pairs showed significant genetic interactions and an overall sign of epistasis changed depending on the condition. Sign epistasis was quite common, but reciprocal sign epistasis was extremally rare. One interaction was common to all conditions, whereas 78% of interactions were specific to only one environment. Although epistatic interactions are quite common, their impact on evolutionary processes will strongly depend on environmental factors. |
| first_indexed | 2024-03-09T16:47:49Z |
| format | Article |
| id | doaj.art-5e41f7885f3741fca5a97c9be0c056e2 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T16:47:49Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-5e41f7885f3741fca5a97c9be0c056e22023-11-24T14:44:08ZengMDPI AGGenes2073-44252023-11-011411208010.3390/genes14112080Genetic Interactions in Various Environmental Conditions in <i>Caenorhabditis elegans</i>Katarzyna Toch0Mateusz Buczek1Marta K. Labocha2Institute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Ul. Gronostajowa 7, 30-387 Krakow, PolandInstitute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Ul. Gronostajowa 7, 30-387 Krakow, PolandInstitute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Ul. Gronostajowa 7, 30-387 Krakow, PolandAlthough it is well known that epistasis plays an important role in many evolutionary processes (e.g., speciation, evolution of sex), our knowledge on the frequency and prevalent sign of epistatic interactions is mainly limited to unicellular organisms or cell cultures of multicellular organisms. This is even more pronounced in regard to how the environment can influence genetic interactions. To broaden our knowledge in that respect we studied gene–gene interactions in a whole multicellular organism, <i>Caenorhabditis elegans</i>. We screened over one thousand gene interactions, each one in standard laboratory conditions, and under three different stressors: heat shock, oxidative stress, and genotoxic stress. Depending on the condition, between 7% and 22% of gene pairs showed significant genetic interactions and an overall sign of epistasis changed depending on the condition. Sign epistasis was quite common, but reciprocal sign epistasis was extremally rare. One interaction was common to all conditions, whereas 78% of interactions were specific to only one environment. Although epistatic interactions are quite common, their impact on evolutionary processes will strongly depend on environmental factors.https://www.mdpi.com/2073-4425/14/11/2080genetic interactionsgene networksenvironmental stressepistasismulticellular |
| spellingShingle | Katarzyna Toch Mateusz Buczek Marta K. Labocha Genetic Interactions in Various Environmental Conditions in <i>Caenorhabditis elegans</i> Genes genetic interactions gene networks environmental stress epistasis multicellular |
| title | Genetic Interactions in Various Environmental Conditions in <i>Caenorhabditis elegans</i> |
| title_full | Genetic Interactions in Various Environmental Conditions in <i>Caenorhabditis elegans</i> |
| title_fullStr | Genetic Interactions in Various Environmental Conditions in <i>Caenorhabditis elegans</i> |
| title_full_unstemmed | Genetic Interactions in Various Environmental Conditions in <i>Caenorhabditis elegans</i> |
| title_short | Genetic Interactions in Various Environmental Conditions in <i>Caenorhabditis elegans</i> |
| title_sort | genetic interactions in various environmental conditions in i caenorhabditis elegans i |
| topic | genetic interactions gene networks environmental stress epistasis multicellular |
| url | https://www.mdpi.com/2073-4425/14/11/2080 |
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