Evaluation of a new tuberculosis-related interferon gamma release assay for tuberculosis infection diagnosis in Huzhou, eastern China
Objective: To compare the performance of a new tuberculosis-related interferon gamma release assay (TB-IGRA) with that of QuantiFERON-TB Gold In-Tube (QFT-GIT) for TB infection diagnosis in China. Materials and Methods: A total of 458 active TB patients and 378 healthy individuals were enrolled. Amo...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2013-01-01
|
| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2013;volume=56;issue=2;spage=125;epage=128;aulast=Qian |
| _version_ | 1819225526809657344 |
|---|---|
| author | Fuchu Qian Weihong Wang Zhihong Qiu Yiqun Shen Jiangfang He Dongli Li Jing Zhong Licheng Dai |
| author_facet | Fuchu Qian Weihong Wang Zhihong Qiu Yiqun Shen Jiangfang He Dongli Li Jing Zhong Licheng Dai |
| author_sort | Fuchu Qian |
| collection | DOAJ |
| description | Objective: To compare the performance of a new tuberculosis-related interferon gamma release assay (TB-IGRA) with that of QuantiFERON-TB Gold In-Tube (QFT-GIT) for TB infection diagnosis in China. Materials and Methods: A total of 458 active TB patients and 378 healthy individuals were enrolled. Among the 458 active TB patients, 395 had pulmonary TB and 63 had extra-pulmonary TB. The blood samples were collected from the active TB patients and health controls; then TB-IGRA and QFT-GIT were used to detect interferon gamma (IFN-γ) levels. Results: The sensitivity, specificity, positive predictive value, and negative predictive value in TB infection diagnosis for active TB by the TB-IGRA were 83.4%, 94.2%, 94.5%, and 82.4%, respectively. For QFT-GIT, the sensitivity, specificity, positive predictive value, and negative predictive value in TB infection diagnosis for active TB were 81.4%, 97.1%, 97.1%, and 81.2%, respectively. Conclusions: TB-IGRA had a high sensitivity and specificity for TB infection; it could be comparable with the QFT-GIT assay. It might be a powerful assisting tool for TB infection diagnosis in the Chinese clinical setting. |
| first_indexed | 2024-12-23T10:11:00Z |
| format | Article |
| id | doaj.art-5e42603b5ac2483086ad1b5875d8f0e8 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-23T10:11:00Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-5e42603b5ac2483086ad1b5875d8f0e82022-12-21T17:50:57ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292013-01-0156212512810.4103/0377-4929.118694Evaluation of a new tuberculosis-related interferon gamma release assay for tuberculosis infection diagnosis in Huzhou, eastern ChinaFuchu QianWeihong WangZhihong QiuYiqun ShenJiangfang HeDongli LiJing ZhongLicheng DaiObjective: To compare the performance of a new tuberculosis-related interferon gamma release assay (TB-IGRA) with that of QuantiFERON-TB Gold In-Tube (QFT-GIT) for TB infection diagnosis in China. Materials and Methods: A total of 458 active TB patients and 378 healthy individuals were enrolled. Among the 458 active TB patients, 395 had pulmonary TB and 63 had extra-pulmonary TB. The blood samples were collected from the active TB patients and health controls; then TB-IGRA and QFT-GIT were used to detect interferon gamma (IFN-γ) levels. Results: The sensitivity, specificity, positive predictive value, and negative predictive value in TB infection diagnosis for active TB by the TB-IGRA were 83.4%, 94.2%, 94.5%, and 82.4%, respectively. For QFT-GIT, the sensitivity, specificity, positive predictive value, and negative predictive value in TB infection diagnosis for active TB were 81.4%, 97.1%, 97.1%, and 81.2%, respectively. Conclusions: TB-IGRA had a high sensitivity and specificity for TB infection; it could be comparable with the QFT-GIT assay. It might be a powerful assisting tool for TB infection diagnosis in the Chinese clinical setting.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2013;volume=56;issue=2;spage=125;epage=128;aulast=QianQuantiFERON-TB gold in-tubeTB-related interferon gamma release assayTuberculosis infection |
| spellingShingle | Fuchu Qian Weihong Wang Zhihong Qiu Yiqun Shen Jiangfang He Dongli Li Jing Zhong Licheng Dai Evaluation of a new tuberculosis-related interferon gamma release assay for tuberculosis infection diagnosis in Huzhou, eastern China Indian Journal of Pathology and Microbiology QuantiFERON-TB gold in-tube TB-related interferon gamma release assay Tuberculosis infection |
| title | Evaluation of a new tuberculosis-related interferon gamma release assay for tuberculosis infection diagnosis in Huzhou, eastern China |
| title_full | Evaluation of a new tuberculosis-related interferon gamma release assay for tuberculosis infection diagnosis in Huzhou, eastern China |
| title_fullStr | Evaluation of a new tuberculosis-related interferon gamma release assay for tuberculosis infection diagnosis in Huzhou, eastern China |
| title_full_unstemmed | Evaluation of a new tuberculosis-related interferon gamma release assay for tuberculosis infection diagnosis in Huzhou, eastern China |
| title_short | Evaluation of a new tuberculosis-related interferon gamma release assay for tuberculosis infection diagnosis in Huzhou, eastern China |
| title_sort | evaluation of a new tuberculosis related interferon gamma release assay for tuberculosis infection diagnosis in huzhou eastern china |
| topic | QuantiFERON-TB gold in-tube TB-related interferon gamma release assay Tuberculosis infection |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2013;volume=56;issue=2;spage=125;epage=128;aulast=Qian |
| work_keys_str_mv | AT fuchuqian evaluationofanewtuberculosisrelatedinterferongammareleaseassayfortuberculosisinfectiondiagnosisinhuzhoueasternchina AT weihongwang evaluationofanewtuberculosisrelatedinterferongammareleaseassayfortuberculosisinfectiondiagnosisinhuzhoueasternchina AT zhihongqiu evaluationofanewtuberculosisrelatedinterferongammareleaseassayfortuberculosisinfectiondiagnosisinhuzhoueasternchina AT yiqunshen evaluationofanewtuberculosisrelatedinterferongammareleaseassayfortuberculosisinfectiondiagnosisinhuzhoueasternchina AT jiangfanghe evaluationofanewtuberculosisrelatedinterferongammareleaseassayfortuberculosisinfectiondiagnosisinhuzhoueasternchina AT donglili evaluationofanewtuberculosisrelatedinterferongammareleaseassayfortuberculosisinfectiondiagnosisinhuzhoueasternchina AT jingzhong evaluationofanewtuberculosisrelatedinterferongammareleaseassayfortuberculosisinfectiondiagnosisinhuzhoueasternchina AT lichengdai evaluationofanewtuberculosisrelatedinterferongammareleaseassayfortuberculosisinfectiondiagnosisinhuzhoueasternchina |