A tale of switched functions: from cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives.

A tale of switched functions: from cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives.

Cyclooxygenase (COX) enzymes are molecular targets of nonsteroidal anti-inflammatory drugs (NSAIDs), the most used medication worldwide. However, the COX enzymes are not the sole molecular targets of NSAIDs. Recently, we showed that two NSAIDs, diclofenac and meclofenamate, also act as openers of Kv...

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Bibliographic Details
Main Authors: Asher Peretz, Nurit Degani-Katzav, Maya Talmon, Eyal Danieli, Anna Gopin, Eti Malka, Rachel Nachman, Amiram Raz, Doron Shabat, Bernard Attali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2131780?pdf=render

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