Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial Design
The aim of this study was to determine the effect of binder and disintegrant excipients toward tablet properties of levofloxacin as the latter tends to suffer brittle fracture upon compression. The excipients used were povidone K-30 as the binder and sodium starch glycolate (SSG) as the disintegrant...
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| Format: | Article |
| Language: | English |
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Fakultas MIPA Universitas Jember
2020-01-01
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| Series: | Jurnal Ilmu Dasar |
| Online Access: | https://jurnal.unej.ac.id/index.php/JID/article/view/10220 |
| _version_ | 1819265444574396416 |
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| author | Dwi Setyawan Widji Soeratri Mahrus Naufal Nuruddin Diajeng Putri Paramita Bambang Widjaja |
| author_facet | Dwi Setyawan Widji Soeratri Mahrus Naufal Nuruddin Diajeng Putri Paramita Bambang Widjaja |
| author_sort | Dwi Setyawan |
| collection | DOAJ |
| description | The aim of this study was to determine the effect of binder and disintegrant excipients toward tablet properties of levofloxacin as the latter tends to suffer brittle fracture upon compression. The excipients used were povidone K-30 as the binder and sodium starch glycolate (SSG) as the disintegrant which the tablets were formulated according to factorial design 22 with two factors and two levels on each factor. Four formulas were prepared by wet granulation method using 2 and 4% of each povidone K-30 and sodium starch glycolate in various compositions. Tablet properties were evaluated for its hardness, friability, and disintegration time as well as dissolution profile. The data obtained was statistically analyzed using Minitab® 17 software to optimize the formulation and resulted in different impacts caused by each excipient. Povidone K-30 exhibited an increment in hardness, friability, disintegration time but a decrease indissolution profile of levofloxacin tablet. SSG decreased hardnessand disintegration time, but increased friability and dissolution profile of levofloxacin tablet. Overlaid contour plot showed that the optimal formula regarding tablet properties of friability, disintegration time, and dissolution profile is in composition of 2.01% povidone K-30 and 2.01% sodium starch glycolate.
Keywords: levofloxacin tablet, povidone K-30, sodium starch glycolate, factorial design. |
| first_indexed | 2024-12-23T20:45:29Z |
| format | Article |
| id | doaj.art-5e43b525e0694dacb679c3634de97eee |
| institution | Directory Open Access Journal |
| issn | 1411-5735 2442-5613 |
| language | English |
| last_indexed | 2024-12-23T20:45:29Z |
| publishDate | 2020-01-01 |
| publisher | Fakultas MIPA Universitas Jember |
| record_format | Article |
| series | Jurnal Ilmu Dasar |
| spelling | doaj.art-5e43b525e0694dacb679c3634de97eee2022-12-21T17:31:48ZengFakultas MIPA Universitas JemberJurnal Ilmu Dasar1411-57352442-56132020-01-01211354210.19184/jid.v21i1.1022010220Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial DesignDwi Setyawan0Widji Soeratri1Mahrus Naufal Nuruddin2Diajeng Putri Paramita3Bambang Widjaja4Department of Pharmaceutics, Faculty of Pharmacy, Universitas AirlanggaDepartment of Pharmaceutics, Faculty of Pharmacy, Universitas AirlanggaDepartment of Pharmaceutics, Faculty of Pharmacy, Universitas AirlanggaDepartment of Pharmaceutics, Faculty of Pharmacy, Universitas AirlanggaDepartment of Pharmacy, Medical Faculty, Universitas Hang TuaThe aim of this study was to determine the effect of binder and disintegrant excipients toward tablet properties of levofloxacin as the latter tends to suffer brittle fracture upon compression. The excipients used were povidone K-30 as the binder and sodium starch glycolate (SSG) as the disintegrant which the tablets were formulated according to factorial design 22 with two factors and two levels on each factor. Four formulas were prepared by wet granulation method using 2 and 4% of each povidone K-30 and sodium starch glycolate in various compositions. Tablet properties were evaluated for its hardness, friability, and disintegration time as well as dissolution profile. The data obtained was statistically analyzed using Minitab® 17 software to optimize the formulation and resulted in different impacts caused by each excipient. Povidone K-30 exhibited an increment in hardness, friability, disintegration time but a decrease indissolution profile of levofloxacin tablet. SSG decreased hardnessand disintegration time, but increased friability and dissolution profile of levofloxacin tablet. Overlaid contour plot showed that the optimal formula regarding tablet properties of friability, disintegration time, and dissolution profile is in composition of 2.01% povidone K-30 and 2.01% sodium starch glycolate. Keywords: levofloxacin tablet, povidone K-30, sodium starch glycolate, factorial design.https://jurnal.unej.ac.id/index.php/JID/article/view/10220 |
| spellingShingle | Dwi Setyawan Widji Soeratri Mahrus Naufal Nuruddin Diajeng Putri Paramita Bambang Widjaja Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial Design Jurnal Ilmu Dasar |
| title | Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial Design |
| title_full | Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial Design |
| title_fullStr | Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial Design |
| title_full_unstemmed | Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial Design |
| title_short | Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial Design |
| title_sort | optimization of povidone k 30 and sodium starch glycolate on levofloxacin tablet by factorial design |
| url | https://jurnal.unej.ac.id/index.php/JID/article/view/10220 |
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