ASSESSMENT OF EFFICIENCY OF ANTI-RELAPSE THERAPY WITH DIENOGEST AFTER SURGERY TREATMENT OF WOMEN WITH COLORECTAL ENDOMETRIOSIS
Purpose of research. To analyze reproductive outcomes and relapses of endometriosis in women after surgical treatment of colorectal endometriosis depending on hormonal therapy.Materials and methods. The article includes data on reproductive outcomes and recurrence of endometriosis in women undergoin...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2018-09-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/2604 |
| _version_ | 1797841428741619712 |
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| author | E. V. Lisovskaya V. D. Chuprynin |
| author_facet | E. V. Lisovskaya V. D. Chuprynin |
| author_sort | E. V. Lisovskaya |
| collection | DOAJ |
| description | Purpose of research. To analyze reproductive outcomes and relapses of endometriosis in women after surgical treatment of colorectal endometriosis depending on hormonal therapy.Materials and methods. The article includes data on reproductive outcomes and recurrence of endometriosis in women undergoing surgical treatment for colorectal endometriosis in the surgical department of Kulakov National Medical Research Centre for Obstetrics, Gynaecology and Perinatology from 2014 to 2016. As an anti-relapse therapy, the first group of women received dienogest (DNG) at a dose of 2 mg/day, the second group included women who received a combined oral contraceptive containing DNG 2 mg + ethinyl estradiol (EE) 0.03 mg for the period of rehabilitation or prior to planning of pregnancy. The comparison group consisted of women who did not receive hormonal drugs in the postoperative period. Data on side effects and tolerability of the drug are also described.Results. During the follow up period from 12 to 48 months, 51 patients were selected for this study, 14 patients were included in the first group, 18 patients were in the second group, 19 patients were in the comparison group. There were no differences in the overall rate of pregnancy depending on the choice of tactics of postoperative management. The highest number of pregnancies (92.3%) occurred during the first year after surgery, which suggests the effect of the duration of hormone therapy on the probability of pregnancy. The lowest number of relapses was registered in the group of long-term monotherapy of DNG. In the group of DNG monotherapy a greater number of side effects were noted, which in most cases did not cause significant discomfort to patients.Conclusion. Long-term administration of DNG at a dose of 2 mg/day after surgical treatment of colorectal endometriosis is an effective means of preventing relapses with good tolerability. However, in some women planning a pregnancy, it may be rational to abandon hormone therapy in favor of earlier pregnancy planning. |
| first_indexed | 2024-04-09T16:30:39Z |
| format | Article |
| id | doaj.art-5e494cb643ac49bca65153e0b34eb19e |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:30:39Z |
| publishDate | 2018-09-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-5e494cb643ac49bca65153e0b34eb19e2023-04-23T06:57:06ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902018-09-01013576010.21518/2079-701X-2018-13-57-602558ASSESSMENT OF EFFICIENCY OF ANTI-RELAPSE THERAPY WITH DIENOGEST AFTER SURGERY TREATMENT OF WOMEN WITH COLORECTAL ENDOMETRIOSISE. V. Lisovskaya0V. D. Chuprynin1Kulakov National Medical Research Centre for Obstetrics, Gynaecology and PerinatologyKulakov National Medical Research Centre for Obstetrics, Gynaecology and PerinatologyPurpose of research. To analyze reproductive outcomes and relapses of endometriosis in women after surgical treatment of colorectal endometriosis depending on hormonal therapy.Materials and methods. The article includes data on reproductive outcomes and recurrence of endometriosis in women undergoing surgical treatment for colorectal endometriosis in the surgical department of Kulakov National Medical Research Centre for Obstetrics, Gynaecology and Perinatology from 2014 to 2016. As an anti-relapse therapy, the first group of women received dienogest (DNG) at a dose of 2 mg/day, the second group included women who received a combined oral contraceptive containing DNG 2 mg + ethinyl estradiol (EE) 0.03 mg for the period of rehabilitation or prior to planning of pregnancy. The comparison group consisted of women who did not receive hormonal drugs in the postoperative period. Data on side effects and tolerability of the drug are also described.Results. During the follow up period from 12 to 48 months, 51 patients were selected for this study, 14 patients were included in the first group, 18 patients were in the second group, 19 patients were in the comparison group. There were no differences in the overall rate of pregnancy depending on the choice of tactics of postoperative management. The highest number of pregnancies (92.3%) occurred during the first year after surgery, which suggests the effect of the duration of hormone therapy on the probability of pregnancy. The lowest number of relapses was registered in the group of long-term monotherapy of DNG. In the group of DNG monotherapy a greater number of side effects were noted, which in most cases did not cause significant discomfort to patients.Conclusion. Long-term administration of DNG at a dose of 2 mg/day after surgical treatment of colorectal endometriosis is an effective means of preventing relapses with good tolerability. However, in some women planning a pregnancy, it may be rational to abandon hormone therapy in favor of earlier pregnancy planning.https://www.med-sovet.pro/jour/article/view/2604colorectal endometriosissurgical treatmentreproductive outcomesanti-relapse therapy |
| spellingShingle | E. V. Lisovskaya V. D. Chuprynin ASSESSMENT OF EFFICIENCY OF ANTI-RELAPSE THERAPY WITH DIENOGEST AFTER SURGERY TREATMENT OF WOMEN WITH COLORECTAL ENDOMETRIOSIS Медицинский совет colorectal endometriosis surgical treatment reproductive outcomes anti-relapse therapy |
| title | ASSESSMENT OF EFFICIENCY OF ANTI-RELAPSE THERAPY WITH DIENOGEST AFTER SURGERY TREATMENT OF WOMEN WITH COLORECTAL ENDOMETRIOSIS |
| title_full | ASSESSMENT OF EFFICIENCY OF ANTI-RELAPSE THERAPY WITH DIENOGEST AFTER SURGERY TREATMENT OF WOMEN WITH COLORECTAL ENDOMETRIOSIS |
| title_fullStr | ASSESSMENT OF EFFICIENCY OF ANTI-RELAPSE THERAPY WITH DIENOGEST AFTER SURGERY TREATMENT OF WOMEN WITH COLORECTAL ENDOMETRIOSIS |
| title_full_unstemmed | ASSESSMENT OF EFFICIENCY OF ANTI-RELAPSE THERAPY WITH DIENOGEST AFTER SURGERY TREATMENT OF WOMEN WITH COLORECTAL ENDOMETRIOSIS |
| title_short | ASSESSMENT OF EFFICIENCY OF ANTI-RELAPSE THERAPY WITH DIENOGEST AFTER SURGERY TREATMENT OF WOMEN WITH COLORECTAL ENDOMETRIOSIS |
| title_sort | assessment of efficiency of anti relapse therapy with dienogest after surgery treatment of women with colorectal endometriosis |
| topic | colorectal endometriosis surgical treatment reproductive outcomes anti-relapse therapy |
| url | https://www.med-sovet.pro/jour/article/view/2604 |
| work_keys_str_mv | AT evlisovskaya assessmentofefficiencyofantirelapsetherapywithdienogestaftersurgerytreatmentofwomenwithcolorectalendometriosis AT vdchuprynin assessmentofefficiencyofantirelapsetherapywithdienogestaftersurgerytreatmentofwomenwithcolorectalendometriosis |