Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
Cardiovascular diseases are the leading causes of the death around the world. An elevation of the low-density lipoprotein cholesterol (LDL-C) level is one of the most important risk factors for cardiovascular diseases. To achieve optimal plasma LDL-C levels, clinal therapies were investigated which...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/11/2666 |
| _version_ | 1797510295772463104 |
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| author | Peng Sun Liang Zhao Nanhai Zhang Jingxuan Zhou Liebing Zhang Wei Wu Baoping Ji Feng Zhou |
| author_facet | Peng Sun Liang Zhao Nanhai Zhang Jingxuan Zhou Liebing Zhang Wei Wu Baoping Ji Feng Zhou |
| author_sort | Peng Sun |
| collection | DOAJ |
| description | Cardiovascular diseases are the leading causes of the death around the world. An elevation of the low-density lipoprotein cholesterol (LDL-C) level is one of the most important risk factors for cardiovascular diseases. To achieve optimal plasma LDL-C levels, clinal therapies were investigated which targeted different metabolism pathways. However, some therapies also caused various adverse effects. Thus, there is a need for new treatment options and/or combination therapies to inhibit the LDL-C level. Dietary polyphenols have received much attention in the prevention of cardiovascular diseases due to their potential LDL-C lowering effects. However, the effectiveness and potential mechanisms of polyphenols in lowering LDL-C is not comprehensively summarized. This review focused on dietary polyphenols that could reduce LDL-C and their mechanisms of action. This review also discussed the limitations and suggestions regarding previous studies. |
| first_indexed | 2024-03-10T05:30:27Z |
| format | Article |
| id | doaj.art-5e49a006ec4e453ea123a6aae504e8dd |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T05:30:27Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-5e49a006ec4e453ea123a6aae504e8dd2023-11-22T23:20:12ZengMDPI AGFoods2304-81582021-11-011011266610.3390/foods10112666Bioactivity of Dietary Polyphenols: The Role in LDL-C LoweringPeng Sun0Liang Zhao1Nanhai Zhang2Jingxuan Zhou3Liebing Zhang4Wei Wu5Baoping Ji6Feng Zhou7Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaBeijing Advance Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaBeijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaBeijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Engineering, China Agricultural University, Beijing 100083, ChinaBeijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaBeijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCardiovascular diseases are the leading causes of the death around the world. An elevation of the low-density lipoprotein cholesterol (LDL-C) level is one of the most important risk factors for cardiovascular diseases. To achieve optimal plasma LDL-C levels, clinal therapies were investigated which targeted different metabolism pathways. However, some therapies also caused various adverse effects. Thus, there is a need for new treatment options and/or combination therapies to inhibit the LDL-C level. Dietary polyphenols have received much attention in the prevention of cardiovascular diseases due to their potential LDL-C lowering effects. However, the effectiveness and potential mechanisms of polyphenols in lowering LDL-C is not comprehensively summarized. This review focused on dietary polyphenols that could reduce LDL-C and their mechanisms of action. This review also discussed the limitations and suggestions regarding previous studies.https://www.mdpi.com/2304-8158/10/11/2666cardiovascular diseasesLDL-Cmetabolism pathwaysdietary polyphenols |
| spellingShingle | Peng Sun Liang Zhao Nanhai Zhang Jingxuan Zhou Liebing Zhang Wei Wu Baoping Ji Feng Zhou Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering Foods cardiovascular diseases LDL-C metabolism pathways dietary polyphenols |
| title | Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering |
| title_full | Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering |
| title_fullStr | Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering |
| title_full_unstemmed | Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering |
| title_short | Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering |
| title_sort | bioactivity of dietary polyphenols the role in ldl c lowering |
| topic | cardiovascular diseases LDL-C metabolism pathways dietary polyphenols |
| url | https://www.mdpi.com/2304-8158/10/11/2666 |
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