Glycopeptide Antibiotics: Structural and Functional Aspects, Human Medicinal Use, and Standardisation
In recent years, glycopeptide antibiotics have been widely used to treat severe bacterial infections. The long-term use of first-generation antibiotics of this group (vancomycin, teicoplanin) has contributed to the emergence of bacteria resistant to them. The problem of resistance has motivated the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)
2023-07-01
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| Series: | Регуляторные исследования и экспертиза лекарственных средств |
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| Online Access: | https://www.vedomostincesmp.ru/jour/article/view/447 |
| _version_ | 1826566702053195776 |
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| author | O. N. Vysochanskaya S. I. Kuleshova E. P. Simonova |
| author_facet | O. N. Vysochanskaya S. I. Kuleshova E. P. Simonova |
| author_sort | O. N. Vysochanskaya |
| collection | DOAJ |
| description | In recent years, glycopeptide antibiotics have been widely used to treat severe bacterial infections. The long-term use of first-generation antibiotics of this group (vancomycin, teicoplanin) has contributed to the emergence of bacteria resistant to them. The problem of resistance has motivated the development of three new glycopeptide antibiotics: dalbavancin, telavancin, and oritavancin. The aim of this study was to consolidate and analyse the data from literature and current quality standards related to glycopeptide antibiotics. The article presents basic information about the discovery of glycopeptide antibiotics of natural origin (vancomycin, teicoplanin) and their derivatives (telavancin, oritavancin, dalbavancin). It briefly characterises the structures of the glycopeptide antibiotics under consideration and describes their main properties, application, and distribution in the pharmaceutical market. The article also gives information on the spectra of antibacterial activity of vancomycin, teicoplanin, and their semi-synthetic derivatives. It considers approaches to vancomycin and teicoplanin standardisation and covers the main requirements of leading pharmacopoeias for the quality of vancomycin, teicoplanin, and the corresponding medicinal products. According to the study results, glycopeptide antibiotics are still widely prescribed because of their high effectiveness in diseases caused by Gram-positive bacteria. However, at present, leading pharmacopoeias have developed and implemented quality standards only for two antibiotics of the group: vancomycin and teicoplanin. According to the results of literature consolidation, further modification of glycopeptide antibiotics is aimed at creating compounds characterised by prolonged action and greater effectiveness against pathogenic microorganisms. Thus, the attention of researchers should be directed to further standardisation of the newest derivatives of glycopeptide antibiotics: telavancin, oritavancin, and dalbavancin. |
| first_indexed | 2024-03-07T19:17:05Z |
| format | Article |
| id | doaj.art-5e4acb65aca14b38939a66953a95eb02 |
| institution | Directory Open Access Journal |
| issn | 3034-3062 3034-3453 |
| language | Russian |
| last_indexed | 2025-03-14T10:55:50Z |
| publishDate | 2023-07-01 |
| publisher | Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) |
| record_format | Article |
| series | Регуляторные исследования и экспертиза лекарственных средств |
| spelling | doaj.art-5e4acb65aca14b38939a66953a95eb022025-03-02T10:46:42ZrusFederal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)Регуляторные исследования и экспертиза лекарственных средств3034-30623034-34532023-07-01132-126127010.30895/1991-2919-2022-447349Glycopeptide Antibiotics: Structural and Functional Aspects, Human Medicinal Use, and StandardisationO. N. Vysochanskaya0S. I. Kuleshova1E. P. Simonova2Scientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsIn recent years, glycopeptide antibiotics have been widely used to treat severe bacterial infections. The long-term use of first-generation antibiotics of this group (vancomycin, teicoplanin) has contributed to the emergence of bacteria resistant to them. The problem of resistance has motivated the development of three new glycopeptide antibiotics: dalbavancin, telavancin, and oritavancin. The aim of this study was to consolidate and analyse the data from literature and current quality standards related to glycopeptide antibiotics. The article presents basic information about the discovery of glycopeptide antibiotics of natural origin (vancomycin, teicoplanin) and their derivatives (telavancin, oritavancin, dalbavancin). It briefly characterises the structures of the glycopeptide antibiotics under consideration and describes their main properties, application, and distribution in the pharmaceutical market. The article also gives information on the spectra of antibacterial activity of vancomycin, teicoplanin, and their semi-synthetic derivatives. It considers approaches to vancomycin and teicoplanin standardisation and covers the main requirements of leading pharmacopoeias for the quality of vancomycin, teicoplanin, and the corresponding medicinal products. According to the study results, glycopeptide antibiotics are still widely prescribed because of their high effectiveness in diseases caused by Gram-positive bacteria. However, at present, leading pharmacopoeias have developed and implemented quality standards only for two antibiotics of the group: vancomycin and teicoplanin. According to the results of literature consolidation, further modification of glycopeptide antibiotics is aimed at creating compounds characterised by prolonged action and greater effectiveness against pathogenic microorganisms. Thus, the attention of researchers should be directed to further standardisation of the newest derivatives of glycopeptide antibiotics: telavancin, oritavancin, and dalbavancin.https://www.vedomostincesmp.ru/jour/article/view/447glycopeptide antibioticsvancomycinteicoplanintelavancinoritavancindalbavancinstructuremechanism of antibacterial actionspectrum of antibacterial actionstandardisation |
| spellingShingle | O. N. Vysochanskaya S. I. Kuleshova E. P. Simonova Glycopeptide Antibiotics: Structural and Functional Aspects, Human Medicinal Use, and Standardisation Регуляторные исследования и экспертиза лекарственных средств glycopeptide antibiotics vancomycin teicoplanin telavancin oritavancin dalbavancin structure mechanism of antibacterial action spectrum of antibacterial action standardisation |
| title | Glycopeptide Antibiotics: Structural and Functional Aspects, Human Medicinal Use, and Standardisation |
| title_full | Glycopeptide Antibiotics: Structural and Functional Aspects, Human Medicinal Use, and Standardisation |
| title_fullStr | Glycopeptide Antibiotics: Structural and Functional Aspects, Human Medicinal Use, and Standardisation |
| title_full_unstemmed | Glycopeptide Antibiotics: Structural and Functional Aspects, Human Medicinal Use, and Standardisation |
| title_short | Glycopeptide Antibiotics: Structural and Functional Aspects, Human Medicinal Use, and Standardisation |
| title_sort | glycopeptide antibiotics structural and functional aspects human medicinal use and standardisation |
| topic | glycopeptide antibiotics vancomycin teicoplanin telavancin oritavancin dalbavancin structure mechanism of antibacterial action spectrum of antibacterial action standardisation |
| url | https://www.vedomostincesmp.ru/jour/article/view/447 |
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