Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis
Idiopathic epilepsy (IE) has been known to be inherited in the Belgian Tervuren for many decades. Risk genotypes for IE in this breed have recently been identified on Canis familiaris chromosomes (CFA) 14 and 37. In the current study, the allele frequencies of these loci were analyzed to determine w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/15/1/114 |
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| author | Nathan Kinsey Janelle M. Belanger Paul J. J. Mandigers Peter A. Leegwater Tiina Heinonen Marjo K. Hytönen Hannes Lohi Elaine A. Ostrander Anita M. Oberbauer |
| author_facet | Nathan Kinsey Janelle M. Belanger Paul J. J. Mandigers Peter A. Leegwater Tiina Heinonen Marjo K. Hytönen Hannes Lohi Elaine A. Ostrander Anita M. Oberbauer |
| author_sort | Nathan Kinsey |
| collection | DOAJ |
| description | Idiopathic epilepsy (IE) has been known to be inherited in the Belgian Tervuren for many decades. Risk genotypes for IE in this breed have recently been identified on Canis familiaris chromosomes (CFA) 14 and 37. In the current study, the allele frequencies of these loci were analyzed to determine whether dog breeders had employed a purposeful selection against IE, leading to a reduction in risk-associated allele frequency within the breed over time. The allele frequencies of two generational groupings of Belgian Tervuren with and without IE were compared. Allele frequencies for risk-associated alleles on CFA14 were unchanged between 1985 and 2015, whereas those on CFA37 increased during that time in the control population (<i>p</i> < 0.05). In contrast, dogs with IE showed a decrease (<i>p</i> < 0.05) in the IE risk-associated allele frequency at the CFA37 locus. Seizure prevalence in the Belgian Tervuren appears to be increasing. These results suggest that, despite awareness that IE is inherited, selection against IE has not been successful. |
| first_indexed | 2024-03-08T10:52:17Z |
| format | Article |
| id | doaj.art-5e4bef0b034c4d1d868db85a763d66eb |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-08T10:52:17Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-5e4bef0b034c4d1d868db85a763d66eb2024-01-26T16:43:40ZengMDPI AGGenes2073-44252024-01-0115111410.3390/genes15010114Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic AnalysisNathan Kinsey0Janelle M. Belanger1Paul J. J. Mandigers2Peter A. Leegwater3Tiina Heinonen4Marjo K. Hytönen5Hannes Lohi6Elaine A. Ostrander7Anita M. Oberbauer8Department of Animal Science, University of California, Davis, CA 95616, USADepartment of Animal Science, University of California, Davis, CA 95616, USADepartment of Clinical Sciences, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The NetherlandsDepartment of Clinical Sciences, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The NetherlandsDepartment of Medical and Clinical Genetics, University of Helsinki, 00014 Helsinki, FinlandDepartment of Medical and Clinical Genetics, University of Helsinki, 00014 Helsinki, FinlandDepartment of Medical and Clinical Genetics, University of Helsinki, 00014 Helsinki, FinlandNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USADepartment of Animal Science, University of California, Davis, CA 95616, USAIdiopathic epilepsy (IE) has been known to be inherited in the Belgian Tervuren for many decades. Risk genotypes for IE in this breed have recently been identified on Canis familiaris chromosomes (CFA) 14 and 37. In the current study, the allele frequencies of these loci were analyzed to determine whether dog breeders had employed a purposeful selection against IE, leading to a reduction in risk-associated allele frequency within the breed over time. The allele frequencies of two generational groupings of Belgian Tervuren with and without IE were compared. Allele frequencies for risk-associated alleles on CFA14 were unchanged between 1985 and 2015, whereas those on CFA37 increased during that time in the control population (<i>p</i> < 0.05). In contrast, dogs with IE showed a decrease (<i>p</i> < 0.05) in the IE risk-associated allele frequency at the CFA37 locus. Seizure prevalence in the Belgian Tervuren appears to be increasing. These results suggest that, despite awareness that IE is inherited, selection against IE has not been successful.https://www.mdpi.com/2073-4425/15/1/114idiopathic epilepsyseizureBelgian Tervurenselective breedingneurological disorderdog |
| spellingShingle | Nathan Kinsey Janelle M. Belanger Paul J. J. Mandigers Peter A. Leegwater Tiina Heinonen Marjo K. Hytönen Hannes Lohi Elaine A. Ostrander Anita M. Oberbauer Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis Genes idiopathic epilepsy seizure Belgian Tervuren selective breeding neurological disorder dog |
| title | Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis |
| title_full | Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis |
| title_fullStr | Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis |
| title_full_unstemmed | Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis |
| title_short | Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis |
| title_sort | idiopathic epilepsy risk allele trends in belgian tervuren a longitudinal genetic analysis |
| topic | idiopathic epilepsy seizure Belgian Tervuren selective breeding neurological disorder dog |
| url | https://www.mdpi.com/2073-4425/15/1/114 |
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