Genome-wide association study reveals novel loci associated with feeding behavior in Pekin ducks
Abstract Background Feeding behavior traits are an essential part of livestock production. However, the genetic base of feeding behavior traits remains unclear in Pekin ducks. This study aimed to determine novel loci related to feeding behavior in Pekin ducks. Results In this study, the feeding info...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | BMC Genomics |
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| Online Access: | https://doi.org/10.1186/s12864-021-07668-1 |
| _version_ | 1818738285054263296 |
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| author | Guang-Sheng Li Feng Zhu Fan Zhang Fang-Xi Yang Jin-Ping Hao Zhuo-Cheng Hou |
| author_facet | Guang-Sheng Li Feng Zhu Fan Zhang Fang-Xi Yang Jin-Ping Hao Zhuo-Cheng Hou |
| author_sort | Guang-Sheng Li |
| collection | DOAJ |
| description | Abstract Background Feeding behavior traits are an essential part of livestock production. However, the genetic base of feeding behavior traits remains unclear in Pekin ducks. This study aimed to determine novel loci related to feeding behavior in Pekin ducks. Results In this study, the feeding information of 540 Pekin ducks was recorded, and individual genotype was evaluated using genotyping-by-sequencing methods. Genome-wide association analysis (GWAS) was conducted for feeding behavior traits. Overall, thirty significant (P-value < 4.74E-06) SNPs for feeding behavior traits were discovered, and four of them reached the genome-wide significance level (P-value < 2.37E-07). One genome-wide significance locus associated with daily meal times was located in a 122.25 Mb region on chromosome 2, which was within the intron of gene ubiquitin-conjugating enzyme E2 E2 (UBE2E2), and could explain 2.64% of the phenotypic variation. This locus was also significantly associated with meal feed intake, and explained 2.72% of this phenotypic variation. Conclusions This study is the first GWAS for feeding behavior traits in ducks. Our results provide a list of candidate genes associated with feeding behavior, and also help to better understand the genetic mechanisms of feeding behavior patterns in ducks. |
| first_indexed | 2024-12-18T01:06:30Z |
| format | Article |
| id | doaj.art-5e4da083c9bc48d4a9a1f75cf53b5ae2 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-18T01:06:30Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-5e4da083c9bc48d4a9a1f75cf53b5ae22022-12-21T21:26:13ZengBMCBMC Genomics1471-21642021-05-012211910.1186/s12864-021-07668-1Genome-wide association study reveals novel loci associated with feeding behavior in Pekin ducksGuang-Sheng Li0Feng Zhu1Fan Zhang2Fang-Xi Yang3Jin-Ping Hao4Zhuo-Cheng Hou5National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, MARA; College of Animal Science and Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, MARA; College of Animal Science and Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, MARA; College of Animal Science and Technology, China Agricultural UniversityBeijing Golden Star IncBeijing Golden Star IncNational Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, MARA; College of Animal Science and Technology, China Agricultural UniversityAbstract Background Feeding behavior traits are an essential part of livestock production. However, the genetic base of feeding behavior traits remains unclear in Pekin ducks. This study aimed to determine novel loci related to feeding behavior in Pekin ducks. Results In this study, the feeding information of 540 Pekin ducks was recorded, and individual genotype was evaluated using genotyping-by-sequencing methods. Genome-wide association analysis (GWAS) was conducted for feeding behavior traits. Overall, thirty significant (P-value < 4.74E-06) SNPs for feeding behavior traits were discovered, and four of them reached the genome-wide significance level (P-value < 2.37E-07). One genome-wide significance locus associated with daily meal times was located in a 122.25 Mb region on chromosome 2, which was within the intron of gene ubiquitin-conjugating enzyme E2 E2 (UBE2E2), and could explain 2.64% of the phenotypic variation. This locus was also significantly associated with meal feed intake, and explained 2.72% of this phenotypic variation. Conclusions This study is the first GWAS for feeding behavior traits in ducks. Our results provide a list of candidate genes associated with feeding behavior, and also help to better understand the genetic mechanisms of feeding behavior patterns in ducks.https://doi.org/10.1186/s12864-021-07668-1Pekin duckFeeding behaviorGenome-wide association analysis |
| spellingShingle | Guang-Sheng Li Feng Zhu Fan Zhang Fang-Xi Yang Jin-Ping Hao Zhuo-Cheng Hou Genome-wide association study reveals novel loci associated with feeding behavior in Pekin ducks BMC Genomics Pekin duck Feeding behavior Genome-wide association analysis |
| title | Genome-wide association study reveals novel loci associated with feeding behavior in Pekin ducks |
| title_full | Genome-wide association study reveals novel loci associated with feeding behavior in Pekin ducks |
| title_fullStr | Genome-wide association study reveals novel loci associated with feeding behavior in Pekin ducks |
| title_full_unstemmed | Genome-wide association study reveals novel loci associated with feeding behavior in Pekin ducks |
| title_short | Genome-wide association study reveals novel loci associated with feeding behavior in Pekin ducks |
| title_sort | genome wide association study reveals novel loci associated with feeding behavior in pekin ducks |
| topic | Pekin duck Feeding behavior Genome-wide association analysis |
| url | https://doi.org/10.1186/s12864-021-07668-1 |
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