Minimal change disease associated with thyroid cancer: a case report
A patient complaining of edema of the face and lower extremities was admitted to the nephrology department for nephrotic syndrome. Renal biopsy revealed findings of minimal change disease (MCD). Thyroid ultrasound showed a hypoechoic 16 × 13 mm nodule in the right lobe, suspicious of malignancy. Lat...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1132259/full |
| _version_ | 1797830031127347200 |
|---|---|
| author | Xiaoyi Cai Xiaoyi Cai Yuenv Wu Qijun Wan Xiuli Zhang |
| author_facet | Xiaoyi Cai Xiaoyi Cai Yuenv Wu Qijun Wan Xiuli Zhang |
| author_sort | Xiaoyi Cai |
| collection | DOAJ |
| description | A patient complaining of edema of the face and lower extremities was admitted to the nephrology department for nephrotic syndrome. Renal biopsy revealed findings of minimal change disease (MCD). Thyroid ultrasound showed a hypoechoic 16 × 13 mm nodule in the right lobe, suspicious of malignancy. Later, total thyroidectomy confirmed the diagnosis of papillary thyroid carcinoma (PTC). After surgery, MCD remitted rapidly and completely, strongly suggesting the diagnosis of MCD secondary to PTC. We report here the first adult case of the paraneoplastic finding of MCD secondary to PTC. Additionally, we discuss the possible role of the BRAF gene in the pathophysiology of PTC-associated MCD in this case and highlight the importance of tumor screening. |
| first_indexed | 2024-04-09T13:29:34Z |
| format | Article |
| id | doaj.art-5e4f4cb2233e4a6bb138617cd05f7e62 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-09T13:29:34Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-5e4f4cb2233e4a6bb138617cd05f7e622023-05-10T04:28:19ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-05-011010.3389/fmed.2023.11322591132259Minimal change disease associated with thyroid cancer: a case reportXiaoyi Cai0Xiaoyi Cai1Yuenv Wu2Qijun Wan3Xiuli Zhang4Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, ChinaMedical College, Shantou University, Shantou, ChinaÉcole Doctorale Interdisciplinaire Sciences-Santé, Université Claude Bernard Lyon 1, Lyon, FranceDepartment of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, ChinaDepartment of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, ChinaA patient complaining of edema of the face and lower extremities was admitted to the nephrology department for nephrotic syndrome. Renal biopsy revealed findings of minimal change disease (MCD). Thyroid ultrasound showed a hypoechoic 16 × 13 mm nodule in the right lobe, suspicious of malignancy. Later, total thyroidectomy confirmed the diagnosis of papillary thyroid carcinoma (PTC). After surgery, MCD remitted rapidly and completely, strongly suggesting the diagnosis of MCD secondary to PTC. We report here the first adult case of the paraneoplastic finding of MCD secondary to PTC. Additionally, we discuss the possible role of the BRAF gene in the pathophysiology of PTC-associated MCD in this case and highlight the importance of tumor screening.https://www.frontiersin.org/articles/10.3389/fmed.2023.1132259/fullminimal change diseasesecondary nephropathyparaneoplastic glomerulopathythyroid cancerBRAF |
| spellingShingle | Xiaoyi Cai Xiaoyi Cai Yuenv Wu Qijun Wan Xiuli Zhang Minimal change disease associated with thyroid cancer: a case report Frontiers in Medicine minimal change disease secondary nephropathy paraneoplastic glomerulopathy thyroid cancer BRAF |
| title | Minimal change disease associated with thyroid cancer: a case report |
| title_full | Minimal change disease associated with thyroid cancer: a case report |
| title_fullStr | Minimal change disease associated with thyroid cancer: a case report |
| title_full_unstemmed | Minimal change disease associated with thyroid cancer: a case report |
| title_short | Minimal change disease associated with thyroid cancer: a case report |
| title_sort | minimal change disease associated with thyroid cancer a case report |
| topic | minimal change disease secondary nephropathy paraneoplastic glomerulopathy thyroid cancer BRAF |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1132259/full |
| work_keys_str_mv | AT xiaoyicai minimalchangediseaseassociatedwiththyroidcanceracasereport AT xiaoyicai minimalchangediseaseassociatedwiththyroidcanceracasereport AT yuenvwu minimalchangediseaseassociatedwiththyroidcanceracasereport AT qijunwan minimalchangediseaseassociatedwiththyroidcanceracasereport AT xiulizhang minimalchangediseaseassociatedwiththyroidcanceracasereport |