Targeting WASF3 Signaling in Metastatic Cancer
Increasing evidence indicates that cancer metastasis is regulated by specific genetic pathways independent of those controlling tumorigenesis and cancer growth. WASF3, a Wiskott–Aldrich syndrome protein family member, appears to play a major role not only in the regulation of actin cytoskeleton dyna...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/2/836 |
| _version_ | 1797410956405374976 |
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| author | Reid Loveless Yong Teng |
| author_facet | Reid Loveless Yong Teng |
| author_sort | Reid Loveless |
| collection | DOAJ |
| description | Increasing evidence indicates that cancer metastasis is regulated by specific genetic pathways independent of those controlling tumorigenesis and cancer growth. WASF3, a Wiskott–Aldrich syndrome protein family member, appears to play a major role not only in the regulation of actin cytoskeleton dynamics but also in cancer cell invasion/metastasis. Recent studies have highlighted that WASF3 is a master regulator and acts as a pivotal scaffolding protein, bringing the various components of metastatic signaling complexes together both spatially and temporally. Herein, targeting WASF3 at the levels of transcription, protein stability, and phosphorylation holds great promise for metastasis suppression, regardless of the diverse genetic backgrounds associated with tumor development. This review focuses on the critical and distinct contributions of WASF3 in the regulation of signal pathways promoting cancer cell invasion and metastasis. |
| first_indexed | 2024-03-09T04:38:02Z |
| format | Article |
| id | doaj.art-5e4fb980ed8e42d78d28f4764266b91b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:38:02Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5e4fb980ed8e42d78d28f4764266b91b2023-12-03T13:25:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122283610.3390/ijms22020836Targeting WASF3 Signaling in Metastatic CancerReid Loveless0Yong Teng1Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USADepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USAIncreasing evidence indicates that cancer metastasis is regulated by specific genetic pathways independent of those controlling tumorigenesis and cancer growth. WASF3, a Wiskott–Aldrich syndrome protein family member, appears to play a major role not only in the regulation of actin cytoskeleton dynamics but also in cancer cell invasion/metastasis. Recent studies have highlighted that WASF3 is a master regulator and acts as a pivotal scaffolding protein, bringing the various components of metastatic signaling complexes together both spatially and temporally. Herein, targeting WASF3 at the levels of transcription, protein stability, and phosphorylation holds great promise for metastasis suppression, regardless of the diverse genetic backgrounds associated with tumor development. This review focuses on the critical and distinct contributions of WASF3 in the regulation of signal pathways promoting cancer cell invasion and metastasis.https://www.mdpi.com/1422-0067/22/2/836WASF3metastasiscancersignaling networkdrug target |
| spellingShingle | Reid Loveless Yong Teng Targeting WASF3 Signaling in Metastatic Cancer International Journal of Molecular Sciences WASF3 metastasis cancer signaling network drug target |
| title | Targeting WASF3 Signaling in Metastatic Cancer |
| title_full | Targeting WASF3 Signaling in Metastatic Cancer |
| title_fullStr | Targeting WASF3 Signaling in Metastatic Cancer |
| title_full_unstemmed | Targeting WASF3 Signaling in Metastatic Cancer |
| title_short | Targeting WASF3 Signaling in Metastatic Cancer |
| title_sort | targeting wasf3 signaling in metastatic cancer |
| topic | WASF3 metastasis cancer signaling network drug target |
| url | https://www.mdpi.com/1422-0067/22/2/836 |
| work_keys_str_mv | AT reidloveless targetingwasf3signalinginmetastaticcancer AT yongteng targetingwasf3signalinginmetastaticcancer |