Utility of EPA CompTox Chemical Dashboard for Next Generation Risk Assessment and Toxicity Prediction of Chemicals
In recent years, the paradigm of toxicity science is moving toward predictive science. New approach methodologies (NAMs), including in chemico, in silico, and in vitro approach, provides a new feasibility to minimize the whole animal toxicity testing. To support these efforts, the U.S. Environmental...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Society of Environmental Engineers
2023-05-01
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| Series: | 대한환경공학회지 |
| Subjects: | |
| Online Access: | http://www.jksee.or.kr/upload/pdf/KSEE-2023-45-5-244.pdf |
| _version_ | 1797803662671609856 |
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| author | Donghyeon Kim Jinhee Choi |
| author_facet | Donghyeon Kim Jinhee Choi |
| author_sort | Donghyeon Kim |
| collection | DOAJ |
| description | In recent years, the paradigm of toxicity science is moving toward predictive science. New approach methodologies (NAMs), including in chemico, in silico, and in vitro approach, provides a new feasibility to minimize the whole animal toxicity testing. To support these efforts, the U.S. Environmental Protection Agency (EPA)’s web-based CompTox Chemical Dashboard was developed and providing relevant data through a curation of diverse substances and predictive tools. In this review, we presented a comprehensive analysis of EPA CompTox Chemical dashboard’s available data, predictive tools and recent case studies using them. We also suggested a perspective of utility of EPA CompTox Chemical Dashboard for implementation of next generation risk assessment and toxicity prediction of environmental chemicals. |
| first_indexed | 2024-03-13T05:25:18Z |
| format | Article |
| id | doaj.art-5e507e69644e49be9250f9a4ad20c9b5 |
| institution | Directory Open Access Journal |
| issn | 1225-5025 2383-7810 |
| language | English |
| last_indexed | 2024-03-13T05:25:18Z |
| publishDate | 2023-05-01 |
| publisher | Korean Society of Environmental Engineers |
| record_format | Article |
| series | 대한환경공학회지 |
| spelling | doaj.art-5e507e69644e49be9250f9a4ad20c9b52023-06-15T07:50:38ZengKorean Society of Environmental Engineers대한환경공학회지1225-50252383-78102023-05-0145524425510.4491/KSEE.2023.45.5.2444463Utility of EPA CompTox Chemical Dashboard for Next Generation Risk Assessment and Toxicity Prediction of ChemicalsDonghyeon Kim0Jinhee ChoiSchool of Environmental Engineering, University of Seoul, Republic of KoreaIn recent years, the paradigm of toxicity science is moving toward predictive science. New approach methodologies (NAMs), including in chemico, in silico, and in vitro approach, provides a new feasibility to minimize the whole animal toxicity testing. To support these efforts, the U.S. Environmental Protection Agency (EPA)’s web-based CompTox Chemical Dashboard was developed and providing relevant data through a curation of diverse substances and predictive tools. In this review, we presented a comprehensive analysis of EPA CompTox Chemical dashboard’s available data, predictive tools and recent case studies using them. We also suggested a perspective of utility of EPA CompTox Chemical Dashboard for implementation of next generation risk assessment and toxicity prediction of environmental chemicals.http://www.jksee.or.kr/upload/pdf/KSEE-2023-45-5-244.pdftoxicity predictionnext generation risk assessmentnew approach methodologiestoxicology databaseepa comptox chemical dashboard |
| spellingShingle | Donghyeon Kim Jinhee Choi Utility of EPA CompTox Chemical Dashboard for Next Generation Risk Assessment and Toxicity Prediction of Chemicals 대한환경공학회지 toxicity prediction next generation risk assessment new approach methodologies toxicology database epa comptox chemical dashboard |
| title | Utility of EPA CompTox Chemical Dashboard for Next Generation Risk Assessment and Toxicity Prediction of Chemicals |
| title_full | Utility of EPA CompTox Chemical Dashboard for Next Generation Risk Assessment and Toxicity Prediction of Chemicals |
| title_fullStr | Utility of EPA CompTox Chemical Dashboard for Next Generation Risk Assessment and Toxicity Prediction of Chemicals |
| title_full_unstemmed | Utility of EPA CompTox Chemical Dashboard for Next Generation Risk Assessment and Toxicity Prediction of Chemicals |
| title_short | Utility of EPA CompTox Chemical Dashboard for Next Generation Risk Assessment and Toxicity Prediction of Chemicals |
| title_sort | utility of epa comptox chemical dashboard for next generation risk assessment and toxicity prediction of chemicals |
| topic | toxicity prediction next generation risk assessment new approach methodologies toxicology database epa comptox chemical dashboard |
| url | http://www.jksee.or.kr/upload/pdf/KSEE-2023-45-5-244.pdf |
| work_keys_str_mv | AT donghyeonkim utilityofepacomptoxchemicaldashboardfornextgenerationriskassessmentandtoxicitypredictionofchemicals AT jinheechoi utilityofepacomptoxchemicaldashboardfornextgenerationriskassessmentandtoxicitypredictionofchemicals |