Clinical Approaches to Nestorone Subdermal Implant Therapy in Women’s Health
Segesterone acetate (SA) or Nestorone, a fourth-generation progestogen, is a synthetic compound with high progestational activity and no androgenic, glucocorticoid, or anabolic effects. However, due to its oral inactivity, SA must be used by other routes, such as subcutaneous. Thus, considering its...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/9/2586 |
| _version_ | 1797581092098670592 |
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| author | Guilherme Renke Consuelo Callizo Raphaela Paes Mariana Antunes Glaycon Michels Luana Concha Ordânio Almeida Christiane Valente Thomaz Baesso Bruna Giovannoni |
| author_facet | Guilherme Renke Consuelo Callizo Raphaela Paes Mariana Antunes Glaycon Michels Luana Concha Ordânio Almeida Christiane Valente Thomaz Baesso Bruna Giovannoni |
| author_sort | Guilherme Renke |
| collection | DOAJ |
| description | Segesterone acetate (SA) or Nestorone, a fourth-generation progestogen, is a synthetic compound with high progestational activity and no androgenic, glucocorticoid, or anabolic effects. However, due to its oral inactivity, SA must be used by other routes, such as subcutaneous. Thus, considering its peculiar properties, the SA subdermal implant is successfully used in female contraception and postmenopausal hormone replacement therapy (HRT). In recent years, its potential uses in endometriosis, polycystic ovaries syndrome (PCOS), and a new therapeutic possibility for neuroprotection have made this treatment extremely interesting. However, the absence of a standardized dose and the long-term safety of SA implant therapy in women is still controversial. Here, we present the possible indications, doses, limitations, and side effects of SA implant therapy. |
| first_indexed | 2024-03-10T23:00:19Z |
| format | Article |
| id | doaj.art-5e50b806b78643f19ac91417f9776cdc |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T23:00:19Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-5e50b806b78643f19ac91417f9776cdc2023-11-19T09:43:23ZengMDPI AGBiomedicines2227-90592023-09-01119258610.3390/biomedicines11092586Clinical Approaches to Nestorone Subdermal Implant Therapy in Women’s HealthGuilherme Renke0Consuelo Callizo1Raphaela Paes2Mariana Antunes3Glaycon Michels4Luana Concha5Ordânio Almeida6Christiane Valente7Thomaz Baesso8Bruna Giovannoni9Nutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, BrazilCentro de Pesquisa e Assistência em Reprodução Humana, Salvador 40210-341, BrazilNutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, BrazilNutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, BrazilNutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, BrazilNutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, BrazilNutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, BrazilNutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, BrazilNutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, BrazilNutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, BrazilSegesterone acetate (SA) or Nestorone, a fourth-generation progestogen, is a synthetic compound with high progestational activity and no androgenic, glucocorticoid, or anabolic effects. However, due to its oral inactivity, SA must be used by other routes, such as subcutaneous. Thus, considering its peculiar properties, the SA subdermal implant is successfully used in female contraception and postmenopausal hormone replacement therapy (HRT). In recent years, its potential uses in endometriosis, polycystic ovaries syndrome (PCOS), and a new therapeutic possibility for neuroprotection have made this treatment extremely interesting. However, the absence of a standardized dose and the long-term safety of SA implant therapy in women is still controversial. Here, we present the possible indications, doses, limitations, and side effects of SA implant therapy.https://www.mdpi.com/2227-9059/11/9/2586contraceptionmenopauseimplantNestoronesegesterone acetatehormone replacement therapy |
| spellingShingle | Guilherme Renke Consuelo Callizo Raphaela Paes Mariana Antunes Glaycon Michels Luana Concha Ordânio Almeida Christiane Valente Thomaz Baesso Bruna Giovannoni Clinical Approaches to Nestorone Subdermal Implant Therapy in Women’s Health Biomedicines contraception menopause implant Nestorone segesterone acetate hormone replacement therapy |
| title | Clinical Approaches to Nestorone Subdermal Implant Therapy in Women’s Health |
| title_full | Clinical Approaches to Nestorone Subdermal Implant Therapy in Women’s Health |
| title_fullStr | Clinical Approaches to Nestorone Subdermal Implant Therapy in Women’s Health |
| title_full_unstemmed | Clinical Approaches to Nestorone Subdermal Implant Therapy in Women’s Health |
| title_short | Clinical Approaches to Nestorone Subdermal Implant Therapy in Women’s Health |
| title_sort | clinical approaches to nestorone subdermal implant therapy in women s health |
| topic | contraception menopause implant Nestorone segesterone acetate hormone replacement therapy |
| url | https://www.mdpi.com/2227-9059/11/9/2586 |
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