Unlocking the Potential: Novel NSAIDs Hybrids Unleash Chemopreventive Power toward Liver Cancer Cells through Nrf2, NF-κB, and MAPK Signaling Pathways

Unlocking the Potential: Novel NSAIDs Hybrids Unleash Chemopreventive Power toward Liver Cancer Cells through Nrf2, NF-κB, and MAPK Signaling Pathways

HCC is a highly aggressive malignancy with limited treatment options. In this study, novel conjugates of non-steroidal anti-inflammatory drugs (NSAIDs)—Ibuprofen and Ketoprofen—with oleanolic acid oximes derivatives (OAO) were synthesized, and their activity as modulators of signaling pathways invol...

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Bibliographic Details
Main Authors: Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Wanda Baer-Dubowska
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molecules
Subjects:
Nrf2
NF-κB
MAPK
HCC
Ibuprofen
Ketoprofen
Online Access:https://www.mdpi.com/1420-3049/28/15/5759

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