Comparison of Hemodynamic and Sedation Effects of Midazolam and Propofol
Aim: In this study, we compared the sedation quality and cardiovascular and respiratory system effects of midazolam versus propofol in patients undergoing spinal anesthesia. Methods: 40 ASA I-III patients aged 20-70 years were enrolled. After spinal anesthesia, in group M (n=20), 0.05 mg/kg/hr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2015-03-01
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| Series: | Haseki Tıp Bülteni |
| Subjects: | |
| Online Access: | http://www.hasekidergisi.com/article_8693/Comparison-Of-Hemodynamic-And-Sedation-Effects-Of-Midazolam-And-Propofol |
| Summary: | Aim: In this study, we compared the sedation quality and
cardiovascular and respiratory system effects of midazolam versus
propofol in patients undergoing spinal anesthesia.
Methods: 40 ASA I-III patients aged 20-70 years were enrolled.
After spinal anesthesia, in group M (n=20), 0.05 mg/kg/hr
midazolam infusion following 0.05 mg/kg bolus of midazolam
and, in group P (n=20), 2.5 mg/kg/s propofol infusion following 1
mg/kg bolus dose of propofol following were started and titrated
until the intended level of sedation was achieved. Blood pressure,
heart rate, SpO2, respiratory rate, sedation scores and side effects
were recorded.
Results: There was no statistically significant difference in blood
pressure, heart rate and SpO2 values between the groups. In group
M, the mean respiratory rate was significantly lower than in group
P. There was no significant difference in sedation scores between
the groups. In comparison of side effects, only superficial breathing
was observed to be significantly higher in group P than in group M.
Conclusion: Propofol and midazolam used for sedation have
minimum effects on hemodinamic and respiratory parameters. We
assume that there is no significant difference between these two
drugs in terms of patient comfort. (The Medical Bulletin of Haseki
2015; 53:20-3 |
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| ISSN: | 1302-0072 2147-2688 |