Elevated Levels of miR-144-3p Induce Cholinergic Degeneration by Impairing the Maturation of NGF in Alzheimer’s Disease

Elevated Levels of miR-144-3p Induce Cholinergic Degeneration by Impairing the Maturation of NGF in Alzheimer’s Disease

Cholinergic degeneration is one of the key pathological hallmarks of Alzheimer’s disease (AD), a condition that is characterized by synaptic disorders and memory impairments. Nerve growth factor (NGF) is secreted in brain regions that receive projections from the basal forebrain cholinergic neurons....

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Bibliographic Details
Main Authors: Lan-Ting Zhou, Juan Zhang, Lu Tan, He-Zhou Huang, Yang Zhou, Zhi-Qiang Liu, Youming Lu, Ling-Qiang Zhu, Chengye Yao, Dan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Alzheimer’s disease
NGF
miR-144-3p
cholinergic degeneration
synaptic disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.667412/full

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