Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases
Abstract N6-methyladenosine (m6A) is a key area in Epigenetics and has been increasingly focused these years. In the m6A process, readers recognize the m6A modification on mRNAs or noncoding RNAs and mediate different downstream events. Emerging studies have shown that YTHDC1, an important m6A reade...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-05-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-022-01040-2 |
| _version_ | 1811308187310096384 |
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| author | Huaqing Yan Liqi Zhang Xiaobo Cui Sinian Zheng Rubing Li |
| author_facet | Huaqing Yan Liqi Zhang Xiaobo Cui Sinian Zheng Rubing Li |
| author_sort | Huaqing Yan |
| collection | DOAJ |
| description | Abstract N6-methyladenosine (m6A) is a key area in Epigenetics and has been increasingly focused these years. In the m6A process, readers recognize the m6A modification on mRNAs or noncoding RNAs and mediate different downstream events. Emerging studies have shown that YTHDC1, an important m6A reader, plays a key role in many biological functions and disease progression, especially cancers. Here we summarized the current mechanisms of YTHDC1 in biological functions and diseases and offered guidance for future researches to provide potential strategy for clinical diagnose and therapy. |
| first_indexed | 2024-04-13T09:18:51Z |
| format | Article |
| id | doaj.art-5e52f79877a8480aa98e7926fcb21890 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-04-13T09:18:51Z |
| publishDate | 2022-05-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-5e52f79877a8480aa98e7926fcb218902022-12-22T02:52:40ZengNature Publishing GroupCell Death Discovery2058-77162022-05-01811710.1038/s41420-022-01040-2Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseasesHuaqing Yan0Liqi Zhang1Xiaobo Cui2Sinian Zheng3Rubing Li4Department of Urology, Ningbo Medical Center Lihuili HospitalDepartment of Reproductive Medicine, Ningbo First HospitalDepartment of Urology, Ningbo Medical Center Lihuili HospitalDepartment of Urology, Ningbo Medical Center Lihuili HospitalDepartment of Urology, Ningbo Medical Center Lihuili HospitalAbstract N6-methyladenosine (m6A) is a key area in Epigenetics and has been increasingly focused these years. In the m6A process, readers recognize the m6A modification on mRNAs or noncoding RNAs and mediate different downstream events. Emerging studies have shown that YTHDC1, an important m6A reader, plays a key role in many biological functions and disease progression, especially cancers. Here we summarized the current mechanisms of YTHDC1 in biological functions and diseases and offered guidance for future researches to provide potential strategy for clinical diagnose and therapy.https://doi.org/10.1038/s41420-022-01040-2 |
| spellingShingle | Huaqing Yan Liqi Zhang Xiaobo Cui Sinian Zheng Rubing Li Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases Cell Death Discovery |
| title | Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases |
| title_full | Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases |
| title_fullStr | Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases |
| title_full_unstemmed | Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases |
| title_short | Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases |
| title_sort | roles and mechanisms of the m6a reader ythdc1 in biological processes and diseases |
| url | https://doi.org/10.1038/s41420-022-01040-2 |
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