Immune mechanisms of group B coxsackievirus induced viral myocarditis
ABSTRACTViral myocarditis is known to be a primary cause of dilated cardiomyopathy (DCM) that can lead to heart failure and sudden cardiac death and is invariably caused by myocardial viral infection following active inflammatory destruction of the myocardium. Although acute viral myocarditis freque...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2023.2180951 |
| _version_ | 1797367196240838656 |
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| author | Yue Zhang Xiaobin Zhou Shuyi Chen Xinchen Sun Chenglin Zhou |
| author_facet | Yue Zhang Xiaobin Zhou Shuyi Chen Xinchen Sun Chenglin Zhou |
| author_sort | Yue Zhang |
| collection | DOAJ |
| description | ABSTRACTViral myocarditis is known to be a primary cause of dilated cardiomyopathy (DCM) that can lead to heart failure and sudden cardiac death and is invariably caused by myocardial viral infection following active inflammatory destruction of the myocardium. Although acute viral myocarditis frequently recovers on its own, current chronic myocarditis therapies are unsatisfactory, where the persistence of viral or immunological insults to the heart may play a role. Cellular and mouse experimental models that utilized the most prevalent Coxsackievirus group B type 3 (CVB3) virus infection causing myocarditis have illustrated the pathophysiology of viral myocarditis. In this review, immunological insights into the different stages of development of viral myocarditis were discussed, concentrating on the mechanisms of innate and adaptive immunity in the development of CVB3-induced myocarditis. |
| first_indexed | 2024-03-08T17:13:48Z |
| format | Article |
| id | doaj.art-5e53125dd1f44f9a81f714587209a310 |
| institution | Directory Open Access Journal |
| issn | 2150-5594 2150-5608 |
| language | English |
| last_indexed | 2024-03-08T17:13:48Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj.art-5e53125dd1f44f9a81f714587209a3102024-01-03T17:26:57ZengTaylor & Francis GroupVirulence2150-55942150-56082023-12-0114110.1080/21505594.2023.2180951Immune mechanisms of group B coxsackievirus induced viral myocarditisYue Zhang0Xiaobin Zhou1Shuyi Chen2Xinchen Sun3Chenglin Zhou4Clinical Medical Laboratory Center, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, ChinaClinical Medical Laboratory Center, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, ChinaClinical Medical Laboratory Center, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, ChinaClinical Medical Laboratory Center, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, ChinaClinical Medical Laboratory Center, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, ChinaABSTRACTViral myocarditis is known to be a primary cause of dilated cardiomyopathy (DCM) that can lead to heart failure and sudden cardiac death and is invariably caused by myocardial viral infection following active inflammatory destruction of the myocardium. Although acute viral myocarditis frequently recovers on its own, current chronic myocarditis therapies are unsatisfactory, where the persistence of viral or immunological insults to the heart may play a role. Cellular and mouse experimental models that utilized the most prevalent Coxsackievirus group B type 3 (CVB3) virus infection causing myocarditis have illustrated the pathophysiology of viral myocarditis. In this review, immunological insights into the different stages of development of viral myocarditis were discussed, concentrating on the mechanisms of innate and adaptive immunity in the development of CVB3-induced myocarditis.https://www.tandfonline.com/doi/10.1080/21505594.2023.2180951Viral myocarditisinnate immunityadaptive immunitypattern recognition receptors (PRRs)T lymphocytes |
| spellingShingle | Yue Zhang Xiaobin Zhou Shuyi Chen Xinchen Sun Chenglin Zhou Immune mechanisms of group B coxsackievirus induced viral myocarditis Virulence Viral myocarditis innate immunity adaptive immunity pattern recognition receptors (PRRs) T lymphocytes |
| title | Immune mechanisms of group B coxsackievirus induced viral myocarditis |
| title_full | Immune mechanisms of group B coxsackievirus induced viral myocarditis |
| title_fullStr | Immune mechanisms of group B coxsackievirus induced viral myocarditis |
| title_full_unstemmed | Immune mechanisms of group B coxsackievirus induced viral myocarditis |
| title_short | Immune mechanisms of group B coxsackievirus induced viral myocarditis |
| title_sort | immune mechanisms of group b coxsackievirus induced viral myocarditis |
| topic | Viral myocarditis innate immunity adaptive immunity pattern recognition receptors (PRRs) T lymphocytes |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2023.2180951 |
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