Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity
Muluken Altaye Ayza, Kaleab Alemayehu Zewdie, Bekalu Amare Tesfaye, Selamawit Tesfamariam Gebrekirstos, Derbew Fikadu Berhe Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Muluken Altaye Ayza Tel +251-916707913 Email Mulealto1@gmail...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-10-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/anti-diabetic-effect-of-telmisartan-through-its-partial-ppargamma-agon-peer-reviewed-article-DMSO |
| _version_ | 1797935615855034368 |
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| author | Ayza MA Zewdie KA Tesfaye BA Gebrekirstos ST Berhe DF |
| author_facet | Ayza MA Zewdie KA Tesfaye BA Gebrekirstos ST Berhe DF |
| author_sort | Ayza MA |
| collection | DOAJ |
| description | Muluken Altaye Ayza, Kaleab Alemayehu Zewdie, Bekalu Amare Tesfaye, Selamawit Tesfamariam Gebrekirstos, Derbew Fikadu Berhe Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Muluken Altaye Ayza Tel +251-916707913 Email Mulealto1@gmail.comAbstract: Telmisartan is an angiotensin II receptor antagonist, which selectively inhibits the angiotensin II type 1 receptor. Thus, it is widely used for hypertension management. Nowadays, telmisartan’s effect on peroxisome proliferator-activated receptors (PPARs) is gaining wider attention. PPARs are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Telmisartan is reported to have a partial PPARγ-agonistic effect while avoiding the safety concerns found with full PPARγ agonists (thiazolidinediones). Telmisartan could be an alternative treatment option, with dual benefit for diabetes mellitus (DM) and hypertension. This review summarizes the anti-diabetic activity of telmisartan via its partial PPARγ-agonistic activity.Keywords: diabetes mellitus, hypertension, peroxisome proliferator-activated receptors, telmisartan |
| first_indexed | 2024-04-10T18:16:52Z |
| format | Article |
| id | doaj.art-5e533ab8d45444739832511dd2413d0e |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:16:52Z |
| publishDate | 2020-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-5e533ab8d45444739832511dd2413d0e2023-02-02T08:31:20ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072020-10-01Volume 133627363558009Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic ActivityAyza MAZewdie KATesfaye BAGebrekirstos STBerhe DFMuluken Altaye Ayza, Kaleab Alemayehu Zewdie, Bekalu Amare Tesfaye, Selamawit Tesfamariam Gebrekirstos, Derbew Fikadu Berhe Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Muluken Altaye Ayza Tel +251-916707913 Email Mulealto1@gmail.comAbstract: Telmisartan is an angiotensin II receptor antagonist, which selectively inhibits the angiotensin II type 1 receptor. Thus, it is widely used for hypertension management. Nowadays, telmisartan’s effect on peroxisome proliferator-activated receptors (PPARs) is gaining wider attention. PPARs are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Telmisartan is reported to have a partial PPARγ-agonistic effect while avoiding the safety concerns found with full PPARγ agonists (thiazolidinediones). Telmisartan could be an alternative treatment option, with dual benefit for diabetes mellitus (DM) and hypertension. This review summarizes the anti-diabetic activity of telmisartan via its partial PPARγ-agonistic activity.Keywords: diabetes mellitus, hypertension, peroxisome proliferator-activated receptors, telmisartanhttps://www.dovepress.com/anti-diabetic-effect-of-telmisartan-through-its-partial-ppargamma-agon-peer-reviewed-article-DMSOdiabetes mellitushypertensionperoxisome proliferator-activated receptorstelmisartan |
| spellingShingle | Ayza MA Zewdie KA Tesfaye BA Gebrekirstos ST Berhe DF Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity Diabetes, Metabolic Syndrome and Obesity diabetes mellitus hypertension peroxisome proliferator-activated receptors telmisartan |
| title | Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity |
| title_full | Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity |
| title_fullStr | Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity |
| title_full_unstemmed | Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity |
| title_short | Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity |
| title_sort | anti diabetic effect of telmisartan through its partial ppar gamma agonistic activity |
| topic | diabetes mellitus hypertension peroxisome proliferator-activated receptors telmisartan |
| url | https://www.dovepress.com/anti-diabetic-effect-of-telmisartan-through-its-partial-ppargamma-agon-peer-reviewed-article-DMSO |
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