Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing
Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in mouse OPCs. β-nicotinamide mononucleotide (β-NMN)...
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Bibliographic Details
| Main Authors: |
Xiao-Ru Ma,
Xudong Zhu,
Yujie Xiao,
Hui-Min Gu,
Shuang-Shuang Zheng,
Liang Li,
Fan Wang,
Zhao-Jun Dong,
Di-Xian Wang,
Yang Wu,
Chenyu Yang,
Wenhong Jiang,
Ke Yao,
Yue Yin,
Yang Zhang,
Chao Peng,
Lixia Gao,
Zhuoxian Meng,
Zeping Hu,
Chong Liu,
Li Li,
Hou-Zao Chen,
Yousheng Shu,
Zhenyu Ju,
Jing-Wei Zhao |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-28844-1
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