Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing
Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in mouse OPCs. β-nicotinamide mononucleotide (β-NMN)...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28844-1 |
| _version_ | 1818137623300931584 |
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| author | Xiao-Ru Ma Xudong Zhu Yujie Xiao Hui-Min Gu Shuang-Shuang Zheng Liang Li Fan Wang Zhao-Jun Dong Di-Xian Wang Yang Wu Chenyu Yang Wenhong Jiang Ke Yao Yue Yin Yang Zhang Chao Peng Lixia Gao Zhuoxian Meng Zeping Hu Chong Liu Li Li Hou-Zao Chen Yousheng Shu Zhenyu Ju Jing-Wei Zhao |
| author_facet | Xiao-Ru Ma Xudong Zhu Yujie Xiao Hui-Min Gu Shuang-Shuang Zheng Liang Li Fan Wang Zhao-Jun Dong Di-Xian Wang Yang Wu Chenyu Yang Wenhong Jiang Ke Yao Yue Yin Yang Zhang Chao Peng Lixia Gao Zhuoxian Meng Zeping Hu Chong Liu Li Li Hou-Zao Chen Yousheng Shu Zhenyu Ju Jing-Wei Zhao |
| author_sort | Xiao-Ru Ma |
| collection | DOAJ |
| description | Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in mouse OPCs. β-nicotinamide mononucleotide (β-NMN) supplement delays myelin aging and enhances remyelination in the aged mice. |
| first_indexed | 2024-12-11T09:59:15Z |
| format | Article |
| id | doaj.art-5e54229427a044a9afccbf8998af649c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-11T09:59:15Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5e54229427a044a9afccbf8998af649c2022-12-22T01:12:09ZengNature PortfolioNature Communications2041-17232022-03-0113111910.1038/s41467-022-28844-1Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageingXiao-Ru Ma0Xudong Zhu1Yujie Xiao2Hui-Min Gu3Shuang-Shuang Zheng4Liang Li5Fan Wang6Zhao-Jun Dong7Di-Xian Wang8Yang Wu9Chenyu Yang10Wenhong Jiang11Ke Yao12Yue Yin13Yang Zhang14Chao Peng15Lixia Gao16Zhuoxian Meng17Zeping Hu18Chong Liu19Li Li20Hou-Zao Chen21Yousheng Shu22Zhenyu Ju23Jing-Wei Zhao24Department of Pathology of Sir Run Run Shaw Hospital and Department of Human Anatomy, Histology and Embryology, System Medicine Research Center, Center for Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of MedicineKey Laboratory of Aging and Cancer Biology of Zhejiang Province, Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Hangzhou Normal UniversityDepartment of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan UniversityDepartment of Pathology of Sir Run Run Shaw Hospital and Department of Human Anatomy, Histology and Embryology, System Medicine Research Center, Center for Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of MedicineDepartment of Pathology of Sir Run Run Shaw Hospital and Department of Human Anatomy, Histology and Embryology, System Medicine Research Center, Center for Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of MedicineDepartment of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan UniversityDepartment of Pathology of Sir Run Run Shaw Hospital and Department of Human Anatomy, Histology and Embryology, System Medicine Research Center, Center for Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of MedicineDepartment of Pathology of Sir Run Run Shaw Hospital and Department of Human Anatomy, Histology and Embryology, System Medicine Research Center, Center for Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of MedicineDepartment of Pathology of Sir Run Run Shaw Hospital and Department of Human Anatomy, Histology and Embryology, System Medicine Research Center, Center for Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of MedicineDepartment of Pathology of Sir Run Run Shaw Hospital and Department of Human Anatomy, Histology and Embryology, System Medicine Research Center, Center for Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of MedicineCenter of Cryo-Electron Microscopy, Zhejiang UniversityZhejiang University School of Brain Science and Brain Medicine, and Department of Neurosurgery of the Second Affiliated Hospital, Zhejiang University School of MedicineSchool of Pharmaceutical Sciences, Tsinghua UniversityNational Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of SciencesDepartment of cardiology, Zhongshan Hospital of Fudan UniversityNational Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of SciencesDepartment of Neurology of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of MedicineDepartment of Pathology and Pathophysiology and Zhejiang Provincial Key Laboratory of Pancreatic Disease of the First Affiliated Hospital, Key Laboratory of Disease Proteomics of Zhejiang Province, Zhejiang University School of MedicineSchool of Pharmaceutical Sciences, Tsinghua UniversityZhejiang University School of Brain Science and Brain Medicine, and Department of Neurosurgery of the Second Affiliated Hospital, Zhejiang University School of MedicineBeijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityKey Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Ageing and Regenerative Medicine, Jinan UniversityDepartment of Pathology of Sir Run Run Shaw Hospital and Department of Human Anatomy, Histology and Embryology, System Medicine Research Center, Center for Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of MedicineAge-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in mouse OPCs. β-nicotinamide mononucleotide (β-NMN) supplement delays myelin aging and enhances remyelination in the aged mice.https://doi.org/10.1038/s41467-022-28844-1 |
| spellingShingle | Xiao-Ru Ma Xudong Zhu Yujie Xiao Hui-Min Gu Shuang-Shuang Zheng Liang Li Fan Wang Zhao-Jun Dong Di-Xian Wang Yang Wu Chenyu Yang Wenhong Jiang Ke Yao Yue Yin Yang Zhang Chao Peng Lixia Gao Zhuoxian Meng Zeping Hu Chong Liu Li Li Hou-Zao Chen Yousheng Shu Zhenyu Ju Jing-Wei Zhao Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing Nature Communications |
| title | Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing |
| title_full | Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing |
| title_fullStr | Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing |
| title_full_unstemmed | Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing |
| title_short | Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing |
| title_sort | restoring nuclear entry of sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing |
| url | https://doi.org/10.1038/s41467-022-28844-1 |
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