FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA

FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA

The role of fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m6A) demethylase, in non-small cell lung cancer (NSCLC) has recently received widespread attention. However the underlying mechanisms of FTO-mediated autophagy regulation in NSCLC progression remain elusive. In this st...

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Bibliographic Details
Main Authors: Kai Wang, Zhiqiang Mei, Meiling Zheng, Xiaoyan Liu, Dabing Li, Haiyong Wang
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
FTO
SESN2
Autophagic flux
mRNA stability
Lung cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024036028

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