Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever
Background and objective: Numerous inflammatory and innate immune pathways are involved in atherogenesis. We aimed to investigate the atherogenic index and other lipid parameters in individuals with familial Mediterranean fever (FMF), as a predictor of atherosclerosis. Materials and methods: A total...
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| Language: | English |
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MDPI AG
2014-01-01
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| Series: | Medicina |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1010660X14001153 |
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| author | Akif Acay Memnune Sena Ulu Ahmet Ahsen Gulay Ozkececi Kasim Demir Ufuk Ozuguz Seref Yuksel Gursel Acarturk |
| author_facet | Akif Acay Memnune Sena Ulu Ahmet Ahsen Gulay Ozkececi Kasim Demir Ufuk Ozuguz Seref Yuksel Gursel Acarturk |
| author_sort | Akif Acay |
| collection | DOAJ |
| description | Background and objective: Numerous inflammatory and innate immune pathways are involved in atherogenesis. We aimed to investigate the atherogenic index and other lipid parameters in individuals with familial Mediterranean fever (FMF), as a predictor of atherosclerosis.
Materials and methods: A total of 60 patients with FMF and 60 healthy age- and sex-matched controls were included in this study. The patients with acute infection, chronic metabolic and rheumatic diseases, use of drugs other than colchicine and smoking history were excluded. CRP, ESR, total cholesterol, triglycerides, LDL-C, and HDL-C levels of patients and the control group were measured. Atherogenic index (TG/HDL-C) was calculated.
Results: We found that the atherogenic index values of the patients were significantly higher than those of the control group. HDL-C levels were lower and ESR and TG levels were higher in patients. Total cholesterol, LDL-C and CRP levels did not differ significantly between the two groups. There was no significant difference in the values of total cholesterol, LDL-C, triglycerides (TG), HDL-C, and atherogenic indexes between the groups of patients with and without M694V mutation.
Conclusions: Elaboration of clinical models of inflammation-induced atherogenesis may further advance our knowledge of multiple inflammatory pathways implicated in atherogenesis and provide a useful tool for cardiovascular prevention. We believe that the atherogenic index also be used as a preliminary indication of accelerated atherosclerosis in FMF. However, large-scale prospective studies on this issue are needed. |
| first_indexed | 2024-03-12T11:13:34Z |
| format | Article |
| id | doaj.art-5e55ac5b94334448a576e6dfeacc926a |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:13:34Z |
| publishDate | 2014-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-5e55ac5b94334448a576e6dfeacc926a2023-09-02T02:27:48ZengMDPI AGMedicina1010-660X2014-01-0150632933310.1016/j.medici.2014.11.009Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean feverAkif Acay0Memnune Sena Ulu1Ahmet Ahsen2Gulay Ozkececi3Kasim Demir4Ufuk Ozuguz5Seref Yuksel6Gursel Acarturk7Department of Internal Medicine, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, TurkeyDepartment of Nephrology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, TurkeyDepartment of Internal Medicine, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, TurkeyDepartment of Cardiology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, TurkeyDepartment of Endocrinology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, TurkeyDepartment of Gastroenterology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, TurkeyDepartment of Nephrology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, TurkeyDepartment of Endocrinology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, TurkeyBackground and objective: Numerous inflammatory and innate immune pathways are involved in atherogenesis. We aimed to investigate the atherogenic index and other lipid parameters in individuals with familial Mediterranean fever (FMF), as a predictor of atherosclerosis. Materials and methods: A total of 60 patients with FMF and 60 healthy age- and sex-matched controls were included in this study. The patients with acute infection, chronic metabolic and rheumatic diseases, use of drugs other than colchicine and smoking history were excluded. CRP, ESR, total cholesterol, triglycerides, LDL-C, and HDL-C levels of patients and the control group were measured. Atherogenic index (TG/HDL-C) was calculated. Results: We found that the atherogenic index values of the patients were significantly higher than those of the control group. HDL-C levels were lower and ESR and TG levels were higher in patients. Total cholesterol, LDL-C and CRP levels did not differ significantly between the two groups. There was no significant difference in the values of total cholesterol, LDL-C, triglycerides (TG), HDL-C, and atherogenic indexes between the groups of patients with and without M694V mutation. Conclusions: Elaboration of clinical models of inflammation-induced atherogenesis may further advance our knowledge of multiple inflammatory pathways implicated in atherogenesis and provide a useful tool for cardiovascular prevention. We believe that the atherogenic index also be used as a preliminary indication of accelerated atherosclerosis in FMF. However, large-scale prospective studies on this issue are needed.http://www.sciencedirect.com/science/article/pii/S1010660X14001153Familial Mediterranean feverInflammationAtherogenic indexAtherosclerosis |
| spellingShingle | Akif Acay Memnune Sena Ulu Ahmet Ahsen Gulay Ozkececi Kasim Demir Ufuk Ozuguz Seref Yuksel Gursel Acarturk Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever Medicina Familial Mediterranean fever Inflammation Atherogenic index Atherosclerosis |
| title | Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever |
| title_full | Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever |
| title_fullStr | Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever |
| title_full_unstemmed | Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever |
| title_short | Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever |
| title_sort | atherogenic index as a predictor of atherosclerosis in subjects with familial mediterranean fever |
| topic | Familial Mediterranean fever Inflammation Atherogenic index Atherosclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S1010660X14001153 |
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