Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems
Currently, most vaccines available on the market are for parental use; however, this may not be the best option on several occasions. Mucosal routes of administration such as intranasal, sublingual, and buccal generate great interest due to the benefits they offer. These range from increasing patien...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/9/10/1177 |
| _version_ | 1827678453045919744 |
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| author | Valeria Trincado Rikhav P. Gala Javier O. Morales |
| author_facet | Valeria Trincado Rikhav P. Gala Javier O. Morales |
| author_sort | Valeria Trincado |
| collection | DOAJ |
| description | Currently, most vaccines available on the market are for parental use; however, this may not be the best option on several occasions. Mucosal routes of administration such as intranasal, sublingual, and buccal generate great interest due to the benefits they offer. These range from increasing patient compliance to inducing a more effective immune response than that achieved through conventional routes. Due to the activation of the common mucosal immune system, it is possible to generate an effective systemic and local immune response, which is not achieved through parenteral administration. Protection against pathogens that use mucosal entry routes is provided by an effective induction of mucosal immunity. Mucosal delivery systems are being developed, such as films and microneedles, which have proven to be effective, safe, and easy to administer. These systems have multiple advantages over commonly used injections, which are simple to manufacture, stable at room temperature, painless for the patient since they do not require puncture. Therefore, these delivery systems do not require to be administered by medical personnel; in fact, they could be self-administered. |
| first_indexed | 2024-03-10T06:09:25Z |
| format | Article |
| id | doaj.art-5e56962455014eee85c3fa030c405c4e |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T06:09:25Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-5e56962455014eee85c3fa030c405c4e2023-11-22T20:16:24ZengMDPI AGVaccines2076-393X2021-10-01910117710.3390/vaccines9101177Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery SystemsValeria Trincado0Rikhav P. Gala1Javier O. Morales2Drug Delivery Laboratory, Departamento de Ciencias y Tecnología Farmacéuticas, Universidad de Chile, Santiago 8380494, ChileBiotechnology Division, Center Mid-Atlantic, Fraunhofer USA, Newark, DE 19702, USADrug Delivery Laboratory, Departamento de Ciencias y Tecnología Farmacéuticas, Universidad de Chile, Santiago 8380494, ChileCurrently, most vaccines available on the market are for parental use; however, this may not be the best option on several occasions. Mucosal routes of administration such as intranasal, sublingual, and buccal generate great interest due to the benefits they offer. These range from increasing patient compliance to inducing a more effective immune response than that achieved through conventional routes. Due to the activation of the common mucosal immune system, it is possible to generate an effective systemic and local immune response, which is not achieved through parenteral administration. Protection against pathogens that use mucosal entry routes is provided by an effective induction of mucosal immunity. Mucosal delivery systems are being developed, such as films and microneedles, which have proven to be effective, safe, and easy to administer. These systems have multiple advantages over commonly used injections, which are simple to manufacture, stable at room temperature, painless for the patient since they do not require puncture. Therefore, these delivery systems do not require to be administered by medical personnel; in fact, they could be self-administered.https://www.mdpi.com/2076-393X/9/10/1177mucosal immunitybuccal vaccinessublingual vaccinesadjuvantsantigen delivery systems |
| spellingShingle | Valeria Trincado Rikhav P. Gala Javier O. Morales Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems Vaccines mucosal immunity buccal vaccines sublingual vaccines adjuvants antigen delivery systems |
| title | Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems |
| title_full | Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems |
| title_fullStr | Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems |
| title_full_unstemmed | Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems |
| title_short | Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems |
| title_sort | buccal and sublingual vaccines a review on oral mucosal immunization and delivery systems |
| topic | mucosal immunity buccal vaccines sublingual vaccines adjuvants antigen delivery systems |
| url | https://www.mdpi.com/2076-393X/9/10/1177 |
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