Aurora Kinase A-YBX1 Synergy Fuels Aggressive Oncogenic Phenotypes and Chemoresistance in Castration-Resistant Prostate Cancer

Aurora Kinase A-YBX1 Synergy Fuels Aggressive Oncogenic Phenotypes and Chemoresistance in Castration-Resistant Prostate Cancer

Multifunctional protein YBX1 upregulation promotes castration-resistant prostate cancer (CRPC). However, YBX1 protein abundance, but not its DNA status or mRNA levels, predicts CRPC recurrence, although the mechanism remains unknown. Similarly, the mechanism by which YBX1 regulates androgen receptor...

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Bibliographic Details
Main Authors: Kumar Nikhil, Asif Raza, Hanan S. Haymour, Benjamin V. Flueckiger, Jiachong Chu, Kavita Shah
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
aurora kinase a (aurka)
ybx1
epithelial to mesenchymal transition
therapy
prostate cancer
crpc
Online Access:https://www.mdpi.com/2072-6694/12/3/660

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