LSDV-Vectored SARS-CoV-2 S and N Vaccine Protects against Severe Clinical Disease in Hamsters

LSDV-Vectored SARS-CoV-2 S and N Vaccine Protects against Severe Clinical Disease in Hamsters

The SARS-CoV-2 pandemic demonstrated the need for potent and broad-spectrum vaccines. This study reports the development and testing of a lumpy skin disease virus (LSDV)-vectored vaccine against SARS-CoV-2, utilizing stabilized spike and conserved nucleocapsid proteins as antigens to develop robust...

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Bibliographic Details
Main Authors: Warren R. J. de Moor, Anna-Lise Williamson, Georgia Schäfer, Nicola Douglass, Sophette Gers, Andrew D. Sutherland, Melissa J. Blumenthal, Emmanuel Margolin, Megan L. Shaw, Wolfgang Preiser, Rosamund Chapman
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Viruses
Subjects:
SARS-CoV-2
LSDV
COVID-19
vaccine
challenge
nucleocapsid
Online Access:https://www.mdpi.com/1999-4915/15/7/1409

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