Common variable immunodeficiency: an important but little-known risk factor for gastric cancer
ABSTRACT Introduction: although it is a rare disease, common variable immunodeficiency (CVID) stands out as the most frequent primary symptomatic immunodeficiency. Carriers are prone to a variety of recurrent bacterial infections, in addition to the risk of developing autoimmune diseases and neopl...
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| Format: | Article |
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Colégio Brasileiro de Cirurgiões
2021-12-01
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| Series: | Revista do Colégio Brasileiro de Cirurgiões |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100236&tlng=en |
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| author | PAULA KREIN GUSTAVO GONÇALVES YOGOLARE MARINA ALESSANDRA PEREIRA OCTAVIO GRECCO MYRTHES ANNA MARAGNA TOLEDO BARROS ANDRE RONCON DIAS ANA KAROLINA BARRETO BERSELLI MARINHO BRUNO ZILBERSTEIN CRISTINA MARIA KOKRON ULYSSES RIBEIRO-JÚNIOR JORGE KALIL SERGIO CARLOS NAHAS MARCUS FERNANDO KODAMA PERTILLE RAMOS |
| author_facet | PAULA KREIN GUSTAVO GONÇALVES YOGOLARE MARINA ALESSANDRA PEREIRA OCTAVIO GRECCO MYRTHES ANNA MARAGNA TOLEDO BARROS ANDRE RONCON DIAS ANA KAROLINA BARRETO BERSELLI MARINHO BRUNO ZILBERSTEIN CRISTINA MARIA KOKRON ULYSSES RIBEIRO-JÚNIOR JORGE KALIL SERGIO CARLOS NAHAS MARCUS FERNANDO KODAMA PERTILLE RAMOS |
| author_sort | PAULA KREIN |
| collection | DOAJ |
| description | ABSTRACT Introduction: although it is a rare disease, common variable immunodeficiency (CVID) stands out as the most frequent primary symptomatic immunodeficiency. Carriers are prone to a variety of recurrent bacterial infections, in addition to the risk of developing autoimmune diseases and neoplasms including gastric cancer (GC). Despite the recognized risk, there are no specific standardized protocols for the management of GC in these patients, so the reported oncological results are varied. Thus, this study aims to describe the clinicopathological characteristics and prognosis of patients with CVID undergoing surgical treatment of GC. Methods: all patients with GC undergoing surgical treatment between 2009 and 2020 were retrospectively evaluated. Later, patients diagnosed with CVID were identified and this group was compared with the remaining patients without any immunodeficiency. Results: among the 1101 patients with GC evaluated in the period, 10 had some type of immunodeficiency, and 5 were diagnosed with CVID. Patients with CVID had younger age, lower BMI, and smaller lesions compared to those without CVID. Four patients underwent curative gastrectomy and one patient underwent jejunostomy. Two patients died (1 palliative and 1 curative) and one patient had disease recurrence. There was no statistically significant difference regarding the incidence of postoperative complications and survival between the evaluated groups. Conclusion: the CVID incidence in patients with GC undergoing surgical treatment was 0.5%, occurring at a less advanced age, but with no difference regarding surgical and oncological results. |
| first_indexed | 2024-04-11T17:13:40Z |
| format | Article |
| id | doaj.art-5e58304cf94541da9f576a9a53eeda4e |
| institution | Directory Open Access Journal |
| issn | 1809-4546 |
| language | English |
| last_indexed | 2024-04-11T17:13:40Z |
| publishDate | 2021-12-01 |
| publisher | Colégio Brasileiro de Cirurgiões |
| record_format | Article |
| series | Revista do Colégio Brasileiro de Cirurgiões |
| spelling | doaj.art-5e58304cf94541da9f576a9a53eeda4e2022-12-22T04:12:49ZengColégio Brasileiro de CirurgiõesRevista do Colégio Brasileiro de Cirurgiões1809-45462021-12-014810.1590/0100-6991e-20213133Common variable immunodeficiency: an important but little-known risk factor for gastric cancerPAULA KREINGUSTAVO GONÇALVES YOGOLAREMARINA ALESSANDRA PEREIRAOCTAVIO GRECCOMYRTHES ANNA MARAGNA TOLEDO BARROSANDRE RONCON DIASANA KAROLINA BARRETO BERSELLI MARINHOBRUNO ZILBERSTEINCRISTINA MARIA KOKRONULYSSES RIBEIRO-JÚNIORJORGE KALILSERGIO CARLOS NAHASMARCUS FERNANDO KODAMA PERTILLE RAMOShttps://orcid.org/0000-0003-0200-7858ABSTRACT Introduction: although it is a rare disease, common variable immunodeficiency (CVID) stands out as the most frequent primary symptomatic immunodeficiency. Carriers are prone to a variety of recurrent bacterial infections, in addition to the risk of developing autoimmune diseases and neoplasms including gastric cancer (GC). Despite the recognized risk, there are no specific standardized protocols for the management of GC in these patients, so the reported oncological results are varied. Thus, this study aims to describe the clinicopathological characteristics and prognosis of patients with CVID undergoing surgical treatment of GC. Methods: all patients with GC undergoing surgical treatment between 2009 and 2020 were retrospectively evaluated. Later, patients diagnosed with CVID were identified and this group was compared with the remaining patients without any immunodeficiency. Results: among the 1101 patients with GC evaluated in the period, 10 had some type of immunodeficiency, and 5 were diagnosed with CVID. Patients with CVID had younger age, lower BMI, and smaller lesions compared to those without CVID. Four patients underwent curative gastrectomy and one patient underwent jejunostomy. Two patients died (1 palliative and 1 curative) and one patient had disease recurrence. There was no statistically significant difference regarding the incidence of postoperative complications and survival between the evaluated groups. Conclusion: the CVID incidence in patients with GC undergoing surgical treatment was 0.5%, occurring at a less advanced age, but with no difference regarding surgical and oncological results.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100236&tlng=enStomach NeoplasmsCommon Variable ImmunodeficiencyEpidemiologyRisk FactorsSurgical Oncology |
| spellingShingle | PAULA KREIN GUSTAVO GONÇALVES YOGOLARE MARINA ALESSANDRA PEREIRA OCTAVIO GRECCO MYRTHES ANNA MARAGNA TOLEDO BARROS ANDRE RONCON DIAS ANA KAROLINA BARRETO BERSELLI MARINHO BRUNO ZILBERSTEIN CRISTINA MARIA KOKRON ULYSSES RIBEIRO-JÚNIOR JORGE KALIL SERGIO CARLOS NAHAS MARCUS FERNANDO KODAMA PERTILLE RAMOS Common variable immunodeficiency: an important but little-known risk factor for gastric cancer Revista do Colégio Brasileiro de Cirurgiões Stomach Neoplasms Common Variable Immunodeficiency Epidemiology Risk Factors Surgical Oncology |
| title | Common variable immunodeficiency: an important but little-known risk factor for gastric cancer |
| title_full | Common variable immunodeficiency: an important but little-known risk factor for gastric cancer |
| title_fullStr | Common variable immunodeficiency: an important but little-known risk factor for gastric cancer |
| title_full_unstemmed | Common variable immunodeficiency: an important but little-known risk factor for gastric cancer |
| title_short | Common variable immunodeficiency: an important but little-known risk factor for gastric cancer |
| title_sort | common variable immunodeficiency an important but little known risk factor for gastric cancer |
| topic | Stomach Neoplasms Common Variable Immunodeficiency Epidemiology Risk Factors Surgical Oncology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100236&tlng=en |
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