Rho GTPases in ameloblast differentiation
During tooth development, ameloblasts differentiate from inner enamel epithelial cells to enamel-forming cells by modulating the signal pathways mediating epithelial–mesenchymal interaction and a cell-autonomous gene network. The differentiation process of epithelial cells is characterized by marked...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-05-01
|
| Series: | Japanese Dental Science Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761615000265 |
| _version_ | 1818366746484015104 |
|---|---|
| author | Keishi Otsu Hidemitsu Harada |
| author_facet | Keishi Otsu Hidemitsu Harada |
| author_sort | Keishi Otsu |
| collection | DOAJ |
| description | During tooth development, ameloblasts differentiate from inner enamel epithelial cells to enamel-forming cells by modulating the signal pathways mediating epithelial–mesenchymal interaction and a cell-autonomous gene network. The differentiation process of epithelial cells is characterized by marked changes in their morphology and polarity, accompanied by dynamic cytoskeletal reorganization and changes in cell–cell and cell–matrix adhesion over time. Functional ameloblasts are tall, columnar, polarized cells that synthesize and secrete enamel-specific proteins. After deposition of the full thickness of enamel matrix, ameloblasts become smaller and regulate enamel maturation. Recent significant advances in the fields of molecular biology and genetics have improved our understanding of the regulatory mechanism of the ameloblast cell life cycle, mediated by the Rho family of small GTPases. They act as intracellular molecular switch that transduce signals from extracellular stimuli to the actin cytoskeleton and the nucleus. In our review, we summarize studies that provide current evidence for Rho GTPases and their involvement in ameloblast differentiation. In addition to the Rho GTPases themselves, their downstream effectors and upstream regulators have also been implicated in ameloblast differentiation. |
| first_indexed | 2024-12-13T22:41:03Z |
| format | Article |
| id | doaj.art-5e5848891fd5417680e46730cffa5f1a |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-12-13T22:41:03Z |
| publishDate | 2016-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-5e5848891fd5417680e46730cffa5f1a2022-12-21T23:28:52ZengElsevierJapanese Dental Science Review1882-76162016-05-01522324010.1016/j.jdsr.2015.09.001Rho GTPases in ameloblast differentiationKeishi OtsuHidemitsu HaradaDuring tooth development, ameloblasts differentiate from inner enamel epithelial cells to enamel-forming cells by modulating the signal pathways mediating epithelial–mesenchymal interaction and a cell-autonomous gene network. The differentiation process of epithelial cells is characterized by marked changes in their morphology and polarity, accompanied by dynamic cytoskeletal reorganization and changes in cell–cell and cell–matrix adhesion over time. Functional ameloblasts are tall, columnar, polarized cells that synthesize and secrete enamel-specific proteins. After deposition of the full thickness of enamel matrix, ameloblasts become smaller and regulate enamel maturation. Recent significant advances in the fields of molecular biology and genetics have improved our understanding of the regulatory mechanism of the ameloblast cell life cycle, mediated by the Rho family of small GTPases. They act as intracellular molecular switch that transduce signals from extracellular stimuli to the actin cytoskeleton and the nucleus. In our review, we summarize studies that provide current evidence for Rho GTPases and their involvement in ameloblast differentiation. In addition to the Rho GTPases themselves, their downstream effectors and upstream regulators have also been implicated in ameloblast differentiation.http://www.sciencedirect.com/science/article/pii/S1882761615000265ToothAmeloblastsRho GTPaseRhoARac1ROCK |
| spellingShingle | Keishi Otsu Hidemitsu Harada Rho GTPases in ameloblast differentiation Japanese Dental Science Review Tooth Ameloblasts Rho GTPase RhoA Rac1 ROCK |
| title | Rho GTPases in ameloblast differentiation |
| title_full | Rho GTPases in ameloblast differentiation |
| title_fullStr | Rho GTPases in ameloblast differentiation |
| title_full_unstemmed | Rho GTPases in ameloblast differentiation |
| title_short | Rho GTPases in ameloblast differentiation |
| title_sort | rho gtpases in ameloblast differentiation |
| topic | Tooth Ameloblasts Rho GTPase RhoA Rac1 ROCK |
| url | http://www.sciencedirect.com/science/article/pii/S1882761615000265 |
| work_keys_str_mv | AT keishiotsu rhogtpasesinameloblastdifferentiation AT hidemitsuharada rhogtpasesinameloblastdifferentiation |