Exploring Autonomic Alterations during Seizures in Temporal Lobe Epilepsy: Insights from a Heart-Rate Variability Analysis
Epilepsy’s impact on cardiovascular function and autonomic regulation, including heart-rate variability, is complex and may contribute to sudden unexpected death in epilepsy (SUDEP). Lateralization of autonomic control in the brain remains the subject of debate; nevertheless, ultra-short-term heart-...
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MDPI AG
2023-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/13/4284 |
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| author | Sung-Min You Baek-Hwan Cho Hyo-Eun Bae Young-Kyun Kim Jae-Rim Kim Soo-Ryun Park Young-Min Shon Dae-Won Seo In-Young Kim |
| author_facet | Sung-Min You Baek-Hwan Cho Hyo-Eun Bae Young-Kyun Kim Jae-Rim Kim Soo-Ryun Park Young-Min Shon Dae-Won Seo In-Young Kim |
| author_sort | Sung-Min You |
| collection | DOAJ |
| description | Epilepsy’s impact on cardiovascular function and autonomic regulation, including heart-rate variability, is complex and may contribute to sudden unexpected death in epilepsy (SUDEP). Lateralization of autonomic control in the brain remains the subject of debate; nevertheless, ultra-short-term heart-rate variability (HRV) analysis is a useful tool for understanding the pathophysiology of autonomic dysfunction in epilepsy patients. A retrospective study reviewed medical records of patients with temporal lobe epilepsy who underwent presurgical evaluations. Data from 75 patients were analyzed and HRV indices were extracted from electrocardiogram recordings of preictal, ictal, and postictal intervals. Various HRV indices were calculated, including time domain, frequency domain, and nonlinear indices, to assess autonomic function during different seizure intervals. The study found significant differences in HRV indices based on hemispheric laterality, language dominancy, hippocampal atrophy, amygdala enlargement, sustained theta activity, and seizure frequency. HRV indices such as the root mean square of successive differences between heartbeats, pNN50, normalized low-frequency, normalized high-frequency, and the low-frequency/high-frequency ratio exhibited significant differences during the ictal period. Language dominancy, hippocampal atrophy, amygdala enlargement, and sustained theta activity were also found to affect HRV. Seizure frequency was correlated with HRV indices, suggesting a potential relationship with the risk of SUDEP. |
| first_indexed | 2024-03-11T01:37:03Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T01:37:03Z |
| publishDate | 2023-06-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-5e58e66b1df54db4a87f9caf0f6068e72023-11-18T16:51:40ZengMDPI AGJournal of Clinical Medicine2077-03832023-06-011213428410.3390/jcm12134284Exploring Autonomic Alterations during Seizures in Temporal Lobe Epilepsy: Insights from a Heart-Rate Variability AnalysisSung-Min You0Baek-Hwan Cho1Hyo-Eun Bae2Young-Kyun Kim3Jae-Rim Kim4Soo-Ryun Park5Young-Min Shon6Dae-Won Seo7In-Young Kim8Department of Biomedical Engineering, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Biomedical Informatics, School of Medicine, CHA University, Seongnam 13488, Republic of KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Biomedical Engineering, Hanyang University, Seoul 04763, Republic of KoreaEpilepsy’s impact on cardiovascular function and autonomic regulation, including heart-rate variability, is complex and may contribute to sudden unexpected death in epilepsy (SUDEP). Lateralization of autonomic control in the brain remains the subject of debate; nevertheless, ultra-short-term heart-rate variability (HRV) analysis is a useful tool for understanding the pathophysiology of autonomic dysfunction in epilepsy patients. A retrospective study reviewed medical records of patients with temporal lobe epilepsy who underwent presurgical evaluations. Data from 75 patients were analyzed and HRV indices were extracted from electrocardiogram recordings of preictal, ictal, and postictal intervals. Various HRV indices were calculated, including time domain, frequency domain, and nonlinear indices, to assess autonomic function during different seizure intervals. The study found significant differences in HRV indices based on hemispheric laterality, language dominancy, hippocampal atrophy, amygdala enlargement, sustained theta activity, and seizure frequency. HRV indices such as the root mean square of successive differences between heartbeats, pNN50, normalized low-frequency, normalized high-frequency, and the low-frequency/high-frequency ratio exhibited significant differences during the ictal period. Language dominancy, hippocampal atrophy, amygdala enlargement, and sustained theta activity were also found to affect HRV. Seizure frequency was correlated with HRV indices, suggesting a potential relationship with the risk of SUDEP.https://www.mdpi.com/2077-0383/12/13/4284epilepsytemporal lobe epilepsyheart-rate variabilityautonomic regulationseizure |
| spellingShingle | Sung-Min You Baek-Hwan Cho Hyo-Eun Bae Young-Kyun Kim Jae-Rim Kim Soo-Ryun Park Young-Min Shon Dae-Won Seo In-Young Kim Exploring Autonomic Alterations during Seizures in Temporal Lobe Epilepsy: Insights from a Heart-Rate Variability Analysis Journal of Clinical Medicine epilepsy temporal lobe epilepsy heart-rate variability autonomic regulation seizure |
| title | Exploring Autonomic Alterations during Seizures in Temporal Lobe Epilepsy: Insights from a Heart-Rate Variability Analysis |
| title_full | Exploring Autonomic Alterations during Seizures in Temporal Lobe Epilepsy: Insights from a Heart-Rate Variability Analysis |
| title_fullStr | Exploring Autonomic Alterations during Seizures in Temporal Lobe Epilepsy: Insights from a Heart-Rate Variability Analysis |
| title_full_unstemmed | Exploring Autonomic Alterations during Seizures in Temporal Lobe Epilepsy: Insights from a Heart-Rate Variability Analysis |
| title_short | Exploring Autonomic Alterations during Seizures in Temporal Lobe Epilepsy: Insights from a Heart-Rate Variability Analysis |
| title_sort | exploring autonomic alterations during seizures in temporal lobe epilepsy insights from a heart rate variability analysis |
| topic | epilepsy temporal lobe epilepsy heart-rate variability autonomic regulation seizure |
| url | https://www.mdpi.com/2077-0383/12/13/4284 |
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