Research progress on effects of traditional Chinese medicine on myocardial ischemia–reperfusion injury: A review
Ischemic heart disease (IHD) is a high-risk disease in the middle-aged and elderly population. The ischemic heart may be further damaged after reperfusion therapy with percutaneous coronary intervention (PCI) and other methods, namely, myocardial ischemia–reperfusion injury (MIRI), which further aff...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1055248/full |
| _version_ | 1811185919493931008 |
|---|---|
| author | Na Xing Na Xing Xiao-Tong Long Xiao-Tong Long Hui-Juan Zhang Hui-Juan Zhang Li-Dan Fu Li-Dan Fu Jian-Yuan Huang Jian-Yuan Huang Abdallah Iddy Chaurembo Abdallah Iddy Chaurembo Abdallah Iddy Chaurembo Francis Chanda Francis Chanda Francis Chanda Yun-Jing Xu Yun-Jing Xu Yun-Jing Xu Chi Shu Chi Shu Kai-Xuan Lin Kai-Xuan Lin Ke Yang Ke Yang Han-Bin Lin Han-Bin Lin Han-Bin Lin |
| author_facet | Na Xing Na Xing Xiao-Tong Long Xiao-Tong Long Hui-Juan Zhang Hui-Juan Zhang Li-Dan Fu Li-Dan Fu Jian-Yuan Huang Jian-Yuan Huang Abdallah Iddy Chaurembo Abdallah Iddy Chaurembo Abdallah Iddy Chaurembo Francis Chanda Francis Chanda Francis Chanda Yun-Jing Xu Yun-Jing Xu Yun-Jing Xu Chi Shu Chi Shu Kai-Xuan Lin Kai-Xuan Lin Ke Yang Ke Yang Han-Bin Lin Han-Bin Lin Han-Bin Lin |
| author_sort | Na Xing |
| collection | DOAJ |
| description | Ischemic heart disease (IHD) is a high-risk disease in the middle-aged and elderly population. The ischemic heart may be further damaged after reperfusion therapy with percutaneous coronary intervention (PCI) and other methods, namely, myocardial ischemia–reperfusion injury (MIRI), which further affects revascularization and hinders patient rehabilitation. Therefore, the investigation of new therapies against MIRI has drawn great global attention. Within the long history of the prevention and treatment of MIRI, traditional Chinese medicine (TCM) has increasingly been recognized by the scientific community for its multi-component and multi-target effects. These multi-target effects provide a conspicuous advantage to the anti-MIRI of TCM to overcome the shortcomings of single-component drugs, thereby pointing toward a novel avenue for the treatment of MIRI. However, very few reviews have summarized the currently available anti-MIRI of TCM. Therefore, a systematic data mining of TCM for protecting against MIRI will certainly accelerate the processes of drug discovery and help to identify safe candidates with synergistic formulations. The present review aims to describe TCM-based research in MIRI treatment through electronic retrieval of articles, patents, and ethnopharmacology documents. This review reported the progress of research on the active ingredients, efficacy, and underlying mechanism of anti-MIRI in TCM and TCM formulas, provided scientific support to the clinical use of TCM in the treatment of MIRI, and revealed the corresponding clinical significance and development prospects of TCM in treating MIRI. |
| first_indexed | 2024-04-11T13:37:35Z |
| format | Article |
| id | doaj.art-5e596cfa92bf4f3aa8a1e502a109f0d9 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T13:37:35Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5e596cfa92bf4f3aa8a1e502a109f0d92022-12-22T04:21:24ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-12-011310.3389/fphar.2022.10552481055248Research progress on effects of traditional Chinese medicine on myocardial ischemia–reperfusion injury: A reviewNa Xing0Na Xing1Xiao-Tong Long2Xiao-Tong Long3Hui-Juan Zhang4Hui-Juan Zhang5Li-Dan Fu6Li-Dan Fu7Jian-Yuan Huang8Jian-Yuan Huang9Abdallah Iddy Chaurembo10Abdallah Iddy Chaurembo11Abdallah Iddy Chaurembo12Francis Chanda13Francis Chanda14Francis Chanda15Yun-Jing Xu16Yun-Jing Xu17Yun-Jing Xu18Chi Shu19Chi Shu20Kai-Xuan Lin21Kai-Xuan Lin22Ke Yang23Ke Yang24Han-Bin Lin25Han-Bin Lin26Han-Bin Lin27Zhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaZhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, ChinaDepartment of Physiology, University of Toronto, Toronto, ON, CanadaZhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, ChinaCollege of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, ChinaZhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, ChinaCollege of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, ChinaZhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, ChinaCollege of Pharmacy, Southern Medical University, Guangzhou, Guangdong, ChinaZhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaZhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaZhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaZhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, ChinaCollege of Food Science, Shenyang Agricultural University, Shenyang, Liaoning, ChinaDepartment of Cardiology, Zhongshan Hospital Affiliated with Guangzhou University of Chinese Medicine (Zhongshan Hospital of Traditional Chinese Medicine), Zhongshan, Guangdong, ChinaGuangzhou University of Chinese Medicine, Guangzhou, ChinaZhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, China0College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang, ChinaZhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaIschemic heart disease (IHD) is a high-risk disease in the middle-aged and elderly population. The ischemic heart may be further damaged after reperfusion therapy with percutaneous coronary intervention (PCI) and other methods, namely, myocardial ischemia–reperfusion injury (MIRI), which further affects revascularization and hinders patient rehabilitation. Therefore, the investigation of new therapies against MIRI has drawn great global attention. Within the long history of the prevention and treatment of MIRI, traditional Chinese medicine (TCM) has increasingly been recognized by the scientific community for its multi-component and multi-target effects. These multi-target effects provide a conspicuous advantage to the anti-MIRI of TCM to overcome the shortcomings of single-component drugs, thereby pointing toward a novel avenue for the treatment of MIRI. However, very few reviews have summarized the currently available anti-MIRI of TCM. Therefore, a systematic data mining of TCM for protecting against MIRI will certainly accelerate the processes of drug discovery and help to identify safe candidates with synergistic formulations. The present review aims to describe TCM-based research in MIRI treatment through electronic retrieval of articles, patents, and ethnopharmacology documents. This review reported the progress of research on the active ingredients, efficacy, and underlying mechanism of anti-MIRI in TCM and TCM formulas, provided scientific support to the clinical use of TCM in the treatment of MIRI, and revealed the corresponding clinical significance and development prospects of TCM in treating MIRI.https://www.frontiersin.org/articles/10.3389/fphar.2022.1055248/fullmyocardial ischemia–reperfusion injurypathogenesistraditional Chinese medicinecardioprotective effectsmolecular mechanisms |
| spellingShingle | Na Xing Na Xing Xiao-Tong Long Xiao-Tong Long Hui-Juan Zhang Hui-Juan Zhang Li-Dan Fu Li-Dan Fu Jian-Yuan Huang Jian-Yuan Huang Abdallah Iddy Chaurembo Abdallah Iddy Chaurembo Abdallah Iddy Chaurembo Francis Chanda Francis Chanda Francis Chanda Yun-Jing Xu Yun-Jing Xu Yun-Jing Xu Chi Shu Chi Shu Kai-Xuan Lin Kai-Xuan Lin Ke Yang Ke Yang Han-Bin Lin Han-Bin Lin Han-Bin Lin Research progress on effects of traditional Chinese medicine on myocardial ischemia–reperfusion injury: A review Frontiers in Pharmacology myocardial ischemia–reperfusion injury pathogenesis traditional Chinese medicine cardioprotective effects molecular mechanisms |
| title | Research progress on effects of traditional Chinese medicine on myocardial ischemia–reperfusion injury: A review |
| title_full | Research progress on effects of traditional Chinese medicine on myocardial ischemia–reperfusion injury: A review |
| title_fullStr | Research progress on effects of traditional Chinese medicine on myocardial ischemia–reperfusion injury: A review |
| title_full_unstemmed | Research progress on effects of traditional Chinese medicine on myocardial ischemia–reperfusion injury: A review |
| title_short | Research progress on effects of traditional Chinese medicine on myocardial ischemia–reperfusion injury: A review |
| title_sort | research progress on effects of traditional chinese medicine on myocardial ischemia reperfusion injury a review |
| topic | myocardial ischemia–reperfusion injury pathogenesis traditional Chinese medicine cardioprotective effects molecular mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1055248/full |
| work_keys_str_mv | AT naxing researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT naxing researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT xiaotonglong researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT xiaotonglong researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT huijuanzhang researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT huijuanzhang researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT lidanfu researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT lidanfu researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT jianyuanhuang researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT jianyuanhuang researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT abdallahiddychaurembo researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT abdallahiddychaurembo researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT abdallahiddychaurembo researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT francischanda researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT francischanda researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT francischanda researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT yunjingxu researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT yunjingxu researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT yunjingxu researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT chishu researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT chishu researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT kaixuanlin researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT kaixuanlin researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT keyang researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT keyang researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT hanbinlin researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT hanbinlin researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview AT hanbinlin researchprogressoneffectsoftraditionalchinesemedicineonmyocardialischemiareperfusioninjuryareview |