Recurrent mantle cell lymphoma in the uterine cervix: a case report
Abstract Background Mantle cell lymphoma is one of several subtypes of non-Hodgkin lymphoma. Cervical relapse of non-Hodgkin lymphoma is a very rare condition that has a variable and nonspecific presentation and may resemble other neoplastic or inflammatory conditions. Case presentation Our patient...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13256-020-02487-6 |
| _version_ | 1828869030351470592 |
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| author | Giusi Santangelo Innocenza Palaia Giorgia Perniola Anna Di Pinto Angela Musella Federica Tomao Margherita Fischetti Carolina Sassu Mariagrazia Piccioni Violante Di Donato Pierluigi Benedetti Panici |
| author_facet | Giusi Santangelo Innocenza Palaia Giorgia Perniola Anna Di Pinto Angela Musella Federica Tomao Margherita Fischetti Carolina Sassu Mariagrazia Piccioni Violante Di Donato Pierluigi Benedetti Panici |
| author_sort | Giusi Santangelo |
| collection | DOAJ |
| description | Abstract Background Mantle cell lymphoma is one of several subtypes of non-Hodgkin lymphoma. Cervical relapse of non-Hodgkin lymphoma is a very rare condition that has a variable and nonspecific presentation and may resemble other neoplastic or inflammatory conditions. Case presentation Our patient was a 58-year-old Caucasian woman who experienced relapse of mantle cell lymphoma with cervical localization. She complained of postmenopausal vaginal bleeding, bladder pressure, and rapid growth of a cervical lesion. An irregular tumor mass of the cervix was visualized during gynecological examination, with findings highly suggestive of locally advanced cervical cancer. Surprisingly, the biopsies showed an extra nodal relapse of mantle cell lymphoma in the cervix. The rarity of this presentation and the scarcity of clinical studies make this type of recurrence very aggressive and difficult to treat. Conclusions Obtaining a definitive histological diagnosis by biopsy or surgical resection and starting appropriate therapy are essential for recovery and treatment of these patients, even if the prognosis is poor. |
| first_indexed | 2024-12-13T05:41:56Z |
| format | Article |
| id | doaj.art-5e5b31049bd3440abb4c84f8a513aa31 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-13T05:41:56Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-5e5b31049bd3440abb4c84f8a513aa312022-12-21T23:57:45ZengBMCJournal of Medical Case Reports1752-19472020-09-011411410.1186/s13256-020-02487-6Recurrent mantle cell lymphoma in the uterine cervix: a case reportGiusi Santangelo0Innocenza Palaia1Giorgia Perniola2Anna Di Pinto3Angela Musella4Federica Tomao5Margherita Fischetti6Carolina Sassu7Mariagrazia Piccioni8Violante Di Donato9Pierluigi Benedetti Panici10Department of Maternal and Child Health and Urological Sciences, Policlinico “Umberto I”, University “Sapienza”Department of Maternal and Child Health and Urological Sciences, Policlinico “Umberto I”, University “Sapienza”Department of Maternal and Child Health and Urological Sciences, Policlinico “Umberto I”, University “Sapienza”Department of Maternal and Child Health and Urological Sciences, Policlinico “Umberto I”, University “Sapienza”Department of Maternal and Child Health and Urological Sciences, Policlinico “Umberto I”, University “Sapienza”Department of Maternal and Child Health and Urological Sciences, Policlinico “Umberto I”, University “Sapienza”Department of Maternal and Child Health and Urological Sciences, Policlinico “Umberto I”, University “Sapienza”Department of Maternal and Child Health and Urological Sciences, Policlinico “Umberto I”, University “Sapienza”Department of Maternal and Child Health and Urological Sciences, Policlinico “Umberto I”, University “Sapienza”Department of Maternal and Child Health and Urological Sciences, Policlinico “Umberto I”, University “Sapienza”Department of Maternal and Child Health and Urological Sciences, Policlinico “Umberto I”, University “Sapienza”Abstract Background Mantle cell lymphoma is one of several subtypes of non-Hodgkin lymphoma. Cervical relapse of non-Hodgkin lymphoma is a very rare condition that has a variable and nonspecific presentation and may resemble other neoplastic or inflammatory conditions. Case presentation Our patient was a 58-year-old Caucasian woman who experienced relapse of mantle cell lymphoma with cervical localization. She complained of postmenopausal vaginal bleeding, bladder pressure, and rapid growth of a cervical lesion. An irregular tumor mass of the cervix was visualized during gynecological examination, with findings highly suggestive of locally advanced cervical cancer. Surprisingly, the biopsies showed an extra nodal relapse of mantle cell lymphoma in the cervix. The rarity of this presentation and the scarcity of clinical studies make this type of recurrence very aggressive and difficult to treat. Conclusions Obtaining a definitive histological diagnosis by biopsy or surgical resection and starting appropriate therapy are essential for recovery and treatment of these patients, even if the prognosis is poor.http://link.springer.com/article/10.1186/s13256-020-02487-6Aggressive non-Hodgkin lymphomaCervixMantle cell lymphomaQuality of lifeRelapsePostmenopausal vaginal bleeding |
| spellingShingle | Giusi Santangelo Innocenza Palaia Giorgia Perniola Anna Di Pinto Angela Musella Federica Tomao Margherita Fischetti Carolina Sassu Mariagrazia Piccioni Violante Di Donato Pierluigi Benedetti Panici Recurrent mantle cell lymphoma in the uterine cervix: a case report Journal of Medical Case Reports Aggressive non-Hodgkin lymphoma Cervix Mantle cell lymphoma Quality of life Relapse Postmenopausal vaginal bleeding |
| title | Recurrent mantle cell lymphoma in the uterine cervix: a case report |
| title_full | Recurrent mantle cell lymphoma in the uterine cervix: a case report |
| title_fullStr | Recurrent mantle cell lymphoma in the uterine cervix: a case report |
| title_full_unstemmed | Recurrent mantle cell lymphoma in the uterine cervix: a case report |
| title_short | Recurrent mantle cell lymphoma in the uterine cervix: a case report |
| title_sort | recurrent mantle cell lymphoma in the uterine cervix a case report |
| topic | Aggressive non-Hodgkin lymphoma Cervix Mantle cell lymphoma Quality of life Relapse Postmenopausal vaginal bleeding |
| url | http://link.springer.com/article/10.1186/s13256-020-02487-6 |
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