Development and validation of a prediction model of perioperative hypoglycemia risk in patients with type 2 diabetes undergoing elective surgery
Abstract Aim To develop and validate a prediction model to evaluate the perioperative hypoglycemia risk in hospitalized type 2 diabetes mellitus (T2DM) patients undergoing elective surgery. Methods We retrospectively analyzed the electronic medical records of 1410 T2DM patients who had been hospital...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Surgery |
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| Online Access: | https://doi.org/10.1186/s12893-022-01601-3 |
| _version_ | 1828553233353670656 |
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| author | Huiwu Han Juan Lai Cheng Yan Xing Li Shuoting Hu Yan He Hong Li |
| author_facet | Huiwu Han Juan Lai Cheng Yan Xing Li Shuoting Hu Yan He Hong Li |
| author_sort | Huiwu Han |
| collection | DOAJ |
| description | Abstract Aim To develop and validate a prediction model to evaluate the perioperative hypoglycemia risk in hospitalized type 2 diabetes mellitus (T2DM) patients undergoing elective surgery. Methods We retrospectively analyzed the electronic medical records of 1410 T2DM patients who had been hospitalized and undergone elective surgery. Regression analysis was used to develop a predictive model for perioperative hypoglycemia risk. The receiver operating characteristic (ROC) curve and the Hosmer–Lemeshow test were used to verify the model. Results Our study showed an incidence of 10.7% for level 1 hypoglycemia and 1.8% for level 2 severe hypoglycemia during the perioperative period. A perioperative hypoglycemic risk prediction model was developed that was mainly composed of four predictors: duration of diabetes ≥ 10 year, body mass index (BMI) < 18.5 kg/m2, standard deviation of blood glucose (SDBG) ≥ 3.0 mmol/L, and preoperative hypoglycemic regimen of insulin subcutaneous. Based on this model, patients were categorized into three groups: low, medium, and high risk. Internal validation of the prediction model showed high discrimination (ROC statistic = 0.715) and good calibration (no significant differences between predicted and observed risk: Pearson χ2 goodness-of-fit P = 0.765). Conclusions The perioperative hypoglycemic risk prediction model categorizes the risk of hypoglycemia using only four predictors and shows good reliability and validity. The model serves as a favorable tool for clinicians to predict hypoglycemic risk and guide future interventions to reduce hypoglycemia risk. |
| first_indexed | 2024-12-12T05:14:57Z |
| format | Article |
| id | doaj.art-5e5bab41d6e14e03ad217690b4f2f290 |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-12-12T05:14:57Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-5e5bab41d6e14e03ad217690b4f2f2902022-12-22T00:36:48ZengBMCBMC Surgery1471-24822022-05-012211810.1186/s12893-022-01601-3Development and validation of a prediction model of perioperative hypoglycemia risk in patients with type 2 diabetes undergoing elective surgeryHuiwu Han0Juan Lai1Cheng Yan2Xing Li3Shuoting Hu4Yan He5Hong Li6Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South UniversityTeaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South UniversityCardiovascular Medicine Department, Xiangya Hospital at Central South UniversityCardiovascular Medicine Department, Xiangya Hospital at Central South UniversityCardiovascular Medicine Department, Xiangya Hospital at Central South UniversityCardiovascular Medicine Department, Xiangya Hospital at Central South UniversityNursing Department, The People’s Hospital of LiuyangAbstract Aim To develop and validate a prediction model to evaluate the perioperative hypoglycemia risk in hospitalized type 2 diabetes mellitus (T2DM) patients undergoing elective surgery. Methods We retrospectively analyzed the electronic medical records of 1410 T2DM patients who had been hospitalized and undergone elective surgery. Regression analysis was used to develop a predictive model for perioperative hypoglycemia risk. The receiver operating characteristic (ROC) curve and the Hosmer–Lemeshow test were used to verify the model. Results Our study showed an incidence of 10.7% for level 1 hypoglycemia and 1.8% for level 2 severe hypoglycemia during the perioperative period. A perioperative hypoglycemic risk prediction model was developed that was mainly composed of four predictors: duration of diabetes ≥ 10 year, body mass index (BMI) < 18.5 kg/m2, standard deviation of blood glucose (SDBG) ≥ 3.0 mmol/L, and preoperative hypoglycemic regimen of insulin subcutaneous. Based on this model, patients were categorized into three groups: low, medium, and high risk. Internal validation of the prediction model showed high discrimination (ROC statistic = 0.715) and good calibration (no significant differences between predicted and observed risk: Pearson χ2 goodness-of-fit P = 0.765). Conclusions The perioperative hypoglycemic risk prediction model categorizes the risk of hypoglycemia using only four predictors and shows good reliability and validity. The model serves as a favorable tool for clinicians to predict hypoglycemic risk and guide future interventions to reduce hypoglycemia risk.https://doi.org/10.1186/s12893-022-01601-3Type 2 diabetes mellitus (T2DM)Elective surgeryPerioperative periodHypoglycemiaRisk prediction model |
| spellingShingle | Huiwu Han Juan Lai Cheng Yan Xing Li Shuoting Hu Yan He Hong Li Development and validation of a prediction model of perioperative hypoglycemia risk in patients with type 2 diabetes undergoing elective surgery BMC Surgery Type 2 diabetes mellitus (T2DM) Elective surgery Perioperative period Hypoglycemia Risk prediction model |
| title | Development and validation of a prediction model of perioperative hypoglycemia risk in patients with type 2 diabetes undergoing elective surgery |
| title_full | Development and validation of a prediction model of perioperative hypoglycemia risk in patients with type 2 diabetes undergoing elective surgery |
| title_fullStr | Development and validation of a prediction model of perioperative hypoglycemia risk in patients with type 2 diabetes undergoing elective surgery |
| title_full_unstemmed | Development and validation of a prediction model of perioperative hypoglycemia risk in patients with type 2 diabetes undergoing elective surgery |
| title_short | Development and validation of a prediction model of perioperative hypoglycemia risk in patients with type 2 diabetes undergoing elective surgery |
| title_sort | development and validation of a prediction model of perioperative hypoglycemia risk in patients with type 2 diabetes undergoing elective surgery |
| topic | Type 2 diabetes mellitus (T2DM) Elective surgery Perioperative period Hypoglycemia Risk prediction model |
| url | https://doi.org/10.1186/s12893-022-01601-3 |
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