Depletion of Thymus-Derived CD4+CD25+ T Cells Abrogates the Suppressive Effects of α-galactosylceramide Treatment on Experimental Allergic Conjunctivitis

Depletion of Thymus-Derived CD4+CD25+ T Cells Abrogates the Suppressive Effects of α-galactosylceramide Treatment on Experimental Allergic Conjunctivitis

Background: We showed previously that α-galactosylceramide (α-GalCer) treatment elevated splenic CD4+ CD25+Foxp3+ T-cell numbers and suppressed the development of experimental allergic conjunctivitis (EC). Here, we investigated whether CD4+CD25+Foxp3+ T cells mediate the suppressive effects of α-Gal...

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Bibliographic Details
Main Authors: Atsuki Fukushima, Tamaki Sumi, Waka Ishida, Ayako Ojima, Minako Kajisako, Hisayuki Ueno, Osamu Taguchi
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Allergology International
Subjects:
allergic conjunctivitis
eosinophils
regulatory T cells
thymus
α-galactosylceramide
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015307796

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