Preventive effects of standardized krill oil on alcohol hangovers in a clinical trial
In this study, we investigated the effect of standardized krill oil on alcohol hangover through a placebo-controlled, randomized, double-blind, and crossover clinical trial. Hangover symptoms including thirst and nausea were alleviated by krill oil at 3 and 4 h, and at 0.5 and 1 h after the alcohol...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622002122 |
| _version_ | 1817968056789368832 |
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| author | Woo-Hyun Kim Hyun-Jeong Lee Da-Yeon Lee Chan-Yang Lee Jeong-Ho Oh Jeong-Eun Kim Kiet Vu Tan Seoung-Ki Kang Byungkwon Kim Seong-Bong Hong Namkyu Yoon Han-Joo Lee Soon-Mi Shim |
| author_facet | Woo-Hyun Kim Hyun-Jeong Lee Da-Yeon Lee Chan-Yang Lee Jeong-Ho Oh Jeong-Eun Kim Kiet Vu Tan Seoung-Ki Kang Byungkwon Kim Seong-Bong Hong Namkyu Yoon Han-Joo Lee Soon-Mi Shim |
| author_sort | Woo-Hyun Kim |
| collection | DOAJ |
| description | In this study, we investigated the effect of standardized krill oil on alcohol hangover through a placebo-controlled, randomized, double-blind, and crossover clinical trial. Hangover symptoms including thirst and nausea were alleviated by krill oil at 3 and 4 h, and at 0.5 and 1 h after the alcohol consumption, respectively (p < 0.05). The breath and blood alcohol concentrations, and Acetaldehyde levels in plasma from the krill oil group were significantly lower than those from the placebo at 1, 3, and 5 h, and at 1, 4, and 5 h, and at 0.5 h after the alcohol consumption, respectively (p < 0.05). Also, krill oil relatively increased alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity, and relatively lowered malondialdehyde (MDA) levels compared to placebo and positive control. Trolox equivalent antioxidant activity of krill oil was higher than the positive control. These results suggest that krill oil can be used as a potential anti-hangover ingredient. |
| first_indexed | 2024-04-13T20:03:59Z |
| format | Article |
| id | doaj.art-5e5c34fc3bea43608a9109c67a0bc2fa |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-13T20:03:59Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-5e5c34fc3bea43608a9109c67a0bc2fa2022-12-22T02:32:06ZengElsevierJournal of Functional Foods1756-46462022-07-0194105142Preventive effects of standardized krill oil on alcohol hangovers in a clinical trialWoo-Hyun Kim0Hyun-Jeong Lee1Da-Yeon Lee2Chan-Yang Lee3Jeong-Ho Oh4Jeong-Eun Kim5Kiet Vu Tan6Seoung-Ki Kang7Byungkwon Kim8Seong-Bong Hong9Namkyu Yoon10Han-Joo Lee11Soon-Mi Shim12Department of Food Science and Biotechnology, Sejong University, Gunja-dong 98, Seoul, 143-747, South KoreaDepartment of Food Science and Biotechnology, Sejong University, Gunja-dong 98, Seoul, 143-747, South KoreaDepartment of Food Science and Biotechnology, Sejong University, Gunja-dong 98, Seoul, 143-747, South KoreaDepartment of Food Science and Biotechnology, Sejong University, Gunja-dong 98, Seoul, 143-747, South KoreaDepartment of Food Science and Biotechnology, Sejong University, Gunja-dong 98, Seoul, 143-747, South KoreaDepartment of Food Science and Biotechnology, Sejong University, Gunja-dong 98, Seoul, 143-747, South KoreaDepartment of Food Science and Biotechnology, Sejong University, Gunja-dong 98, Seoul, 143-747, South KoreaGraduate School of Education, YongIn University, Gyeonggi-do 17092, South KoreaAcademic Credit Bank System Department Physical Education, Yongin University, Gyeonggi-do 17092, South KoreaCollege of Sport Science, SungKyunKwan University, Gyeonggi-do 16419, South KoreaYongin Techno Valley, Ari B&C, Yongin-si, Gyeonggi-do 16914, South KoreaYongin Techno Valley, Ari B&C, Yongin-si, Gyeonggi-do 16914, South KoreaDepartment of Food Science and Biotechnology, Sejong University, Gunja-dong 98, Seoul, 143-747, South Korea; Corresponding author.In this study, we investigated the effect of standardized krill oil on alcohol hangover through a placebo-controlled, randomized, double-blind, and crossover clinical trial. Hangover symptoms including thirst and nausea were alleviated by krill oil at 3 and 4 h, and at 0.5 and 1 h after the alcohol consumption, respectively (p < 0.05). The breath and blood alcohol concentrations, and Acetaldehyde levels in plasma from the krill oil group were significantly lower than those from the placebo at 1, 3, and 5 h, and at 1, 4, and 5 h, and at 0.5 h after the alcohol consumption, respectively (p < 0.05). Also, krill oil relatively increased alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity, and relatively lowered malondialdehyde (MDA) levels compared to placebo and positive control. Trolox equivalent antioxidant activity of krill oil was higher than the positive control. These results suggest that krill oil can be used as a potential anti-hangover ingredient.http://www.sciencedirect.com/science/article/pii/S1756464622002122Krill oilAlcohol hangoverClinical studyBlood alcoholBreath alcoholAntioxidant activity |
| spellingShingle | Woo-Hyun Kim Hyun-Jeong Lee Da-Yeon Lee Chan-Yang Lee Jeong-Ho Oh Jeong-Eun Kim Kiet Vu Tan Seoung-Ki Kang Byungkwon Kim Seong-Bong Hong Namkyu Yoon Han-Joo Lee Soon-Mi Shim Preventive effects of standardized krill oil on alcohol hangovers in a clinical trial Journal of Functional Foods Krill oil Alcohol hangover Clinical study Blood alcohol Breath alcohol Antioxidant activity |
| title | Preventive effects of standardized krill oil on alcohol hangovers in a clinical trial |
| title_full | Preventive effects of standardized krill oil on alcohol hangovers in a clinical trial |
| title_fullStr | Preventive effects of standardized krill oil on alcohol hangovers in a clinical trial |
| title_full_unstemmed | Preventive effects of standardized krill oil on alcohol hangovers in a clinical trial |
| title_short | Preventive effects of standardized krill oil on alcohol hangovers in a clinical trial |
| title_sort | preventive effects of standardized krill oil on alcohol hangovers in a clinical trial |
| topic | Krill oil Alcohol hangover Clinical study Blood alcohol Breath alcohol Antioxidant activity |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622002122 |
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