Diagnosis of fungal keratitis caused by Nectria haematococca through next-generation sequencing: review of literature and report of three cases
Objectives: Fungal keratitis (FK) is a kind of serious corneal infection and penetrating keratoplasty (PKP) is needed when medical therapy fails. Although Nectria haematococca is found as endophytes in the roots of some plant species, there has been no report of N. haematococca infection in human. M...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222006701 |
| _version_ | 1797850297476841472 |
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| author | Wei Wang Ban Luo Xu Yuan Lingjuan Xu Jing Gao Shiliang Liu Chaohua Den Yongyao Tan Guanyu Su Zhongju Chen Hong Zhang Zhifen Zheng Guigang Li Xiongwu Zhou |
| author_facet | Wei Wang Ban Luo Xu Yuan Lingjuan Xu Jing Gao Shiliang Liu Chaohua Den Yongyao Tan Guanyu Su Zhongju Chen Hong Zhang Zhifen Zheng Guigang Li Xiongwu Zhou |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | Objectives: Fungal keratitis (FK) is a kind of serious corneal infection and penetrating keratoplasty (PKP) is needed when medical therapy fails. Although Nectria haematococca is found as endophytes in the roots of some plant species, there has been no report of N. haematococca infection in human. Methods: We reviewed 46 patients who underwent PKP due to FK in our hospital from July 2021 to December 2021, and there were three patients who had relapsed. The next-generation sequencing revealed that all three corneas were infected with N. haematococca. Results: Based on the ocular manifestation and treatment course of three cases, we summarize the characteristics of N. haematococca FK: the scope of corneal infection was widespread with severe hypopyon. The effect of local use of fluconazole and voriconazole was not ideal, and PKP was the main treatment. Even after a large-scale corneal lesion resection, the lesion may recur. The recurrence occurred primarily in the second week after PKP. Conclusion: This is the first clinical report of N. haematococca infection in humans. Compared with the other currently known FK caused by the Fusarium solani species complex, N. haematococca keratitis is more severe and more likely to recur. |
| first_indexed | 2024-04-09T18:58:05Z |
| format | Article |
| id | doaj.art-5e5c7ec60a814873957b6af68b4275bd |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-09T18:58:05Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-5e5c7ec60a814873957b6af68b4275bd2023-04-09T05:45:59ZengElsevierInternational Journal of Infectious Diseases1201-97122023-06-011315356Diagnosis of fungal keratitis caused by Nectria haematococca through next-generation sequencing: review of literature and report of three casesWei Wang0Ban Luo1Xu Yuan2Lingjuan Xu3Jing Gao4Shiliang Liu5Chaohua Den6Yongyao Tan7Guanyu Su8Zhongju Chen9Hong Zhang10Zhifen Zheng11Guigang Li12Xiongwu Zhou13Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBGI-Wuhan Clinical Laboratories, BGI-Shenzhen, Wuhan, ChinaDepartment of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Corresponding author.Objectives: Fungal keratitis (FK) is a kind of serious corneal infection and penetrating keratoplasty (PKP) is needed when medical therapy fails. Although Nectria haematococca is found as endophytes in the roots of some plant species, there has been no report of N. haematococca infection in human. Methods: We reviewed 46 patients who underwent PKP due to FK in our hospital from July 2021 to December 2021, and there were three patients who had relapsed. The next-generation sequencing revealed that all three corneas were infected with N. haematococca. Results: Based on the ocular manifestation and treatment course of three cases, we summarize the characteristics of N. haematococca FK: the scope of corneal infection was widespread with severe hypopyon. The effect of local use of fluconazole and voriconazole was not ideal, and PKP was the main treatment. Even after a large-scale corneal lesion resection, the lesion may recur. The recurrence occurred primarily in the second week after PKP. Conclusion: This is the first clinical report of N. haematococca infection in humans. Compared with the other currently known FK caused by the Fusarium solani species complex, N. haematococca keratitis is more severe and more likely to recur.http://www.sciencedirect.com/science/article/pii/S1201971222006701KeratitisFungusNext-generation sequencing |
| spellingShingle | Wei Wang Ban Luo Xu Yuan Lingjuan Xu Jing Gao Shiliang Liu Chaohua Den Yongyao Tan Guanyu Su Zhongju Chen Hong Zhang Zhifen Zheng Guigang Li Xiongwu Zhou Diagnosis of fungal keratitis caused by Nectria haematococca through next-generation sequencing: review of literature and report of three cases International Journal of Infectious Diseases Keratitis Fungus Next-generation sequencing |
| title | Diagnosis of fungal keratitis caused by Nectria haematococca through next-generation sequencing: review of literature and report of three cases |
| title_full | Diagnosis of fungal keratitis caused by Nectria haematococca through next-generation sequencing: review of literature and report of three cases |
| title_fullStr | Diagnosis of fungal keratitis caused by Nectria haematococca through next-generation sequencing: review of literature and report of three cases |
| title_full_unstemmed | Diagnosis of fungal keratitis caused by Nectria haematococca through next-generation sequencing: review of literature and report of three cases |
| title_short | Diagnosis of fungal keratitis caused by Nectria haematococca through next-generation sequencing: review of literature and report of three cases |
| title_sort | diagnosis of fungal keratitis caused by nectria haematococca through next generation sequencing review of literature and report of three cases |
| topic | Keratitis Fungus Next-generation sequencing |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222006701 |
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